Drugs, food or drink for improving pancreatic functions
A pancreas and functional technology, applied in the direction of food preparation, drug combination, plant raw materials, etc., can solve the problem of complete synthesis that is not or has not been reported
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[0056] Preferred embodiments of the present invention will be explained in detail below. However, the present invention is not limited to the following preferred embodiments, and the present invention can be changed freely within the scope of the present invention.
[0057] The compound used as the active ingredient of the medicine and food or drink of the present invention (hereinafter also referred to as "the compound of the present invention") is a compound having a structure represented by the above chemical formula (1), that is, 3-O-β-D-pyridine Glucopyranosyl-4-methyl-ergost-7-en-3-ol. That is, the compound of the present invention has a structure formed by dehydration condensation of the hydroxyl group at the 3-position of 4-methyl-ergost-7-en-3-ol and the hydroxyl group at the 1-position of D-glucose.
[0058] In addition, the composition used as an active ingredient of the medicine and food or drink of the present invention (hereinafter also referred to as "the compo...
preparation Embodiment 1
[0094] An example of the production of 3-O-β-D-glucopyranosyl-4-methyl-ergost-7-en-3-ol from Aloe vera is described below.
[0095] 3-O-β-D-glucopyranosyl-4-methyl-ergost-7-en-3-ol was extracted and purified from Aloe vera as follows.
[0096]Using a homogenizer, 100 liters of an ethyl acetate / butanol mixture (3:1) was added and stirred to liquefy an amount of 100 kg of mesophyll (clear gel part) of Aloe vera.
[0097] The mixture was left standing overnight, the ethyl acetate / butanol mixture and the aqueous layer were separated, and the ethyl acetate / butanol mixture was recovered. The extract from the ethyl acetate / butanol mixture obtained by concentrating the ethyl acetate / butanol mixture under reduced pressure weighed 13.5 g.
[0098] The hyperglycemia-improving effect of the above aqueous layer and the ethyl acetate / butanol mixture extract was evaluated on the glucose mouse model described in Reference Example 1 below, and the effect was observed for the ethyl acetate / but...
preparation Embodiment 2
[0136] The mesophyll (clear gel part) of Aloe vera is heated and dried, and 60 milliliters of 60%, 80% or 100% ethanol is added to the dry Aloe vera powder of 0.3 gram cracking, and the mixture is heated and refluxed at 60° C. for 1 hour. The extract was centrifuged at 1500 rpm for 20 minutes, and the supernatant was concentrated under reduced pressure to completely remove ethanol, thereby obtaining a crude extract. Dry weights of crude extracts obtained by extraction with 60%, 80% or 100% ethanol were 65, 42 and 8 mg, respectively. Thin layer chromatography confirmed that these crude extracts contained 3-O-β-D-glucopyranosyl-4-methyl-ergost-7-en-3-ol.
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