Vincristine-PEG-PLGA segmented copolymer nanoparticle, its preparation method and use
A -PEG-PLGA, block copolymer technology, applied in the field of medicine, can solve the problems of toxicity, low efficiency and complex preparation procedures of degradants, and achieve the effects of reducing toxic side effects, prolonging time and increasing compliance
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[0024] The vincristine-PEG-PLGA block copolymer nanoparticles of the present invention are prepared by encapsulating vincristine in PEG-PLGA.
[0025] Among them, vincristine uses its sulfate-vincristine sulfate (VCR).
[0026] The ratio of vincristine and PEG-PLGA is as follows:
[0027] Vincristine: PEG-PLGA block copolymer=1:10~1:1000.
[0028] Preparation of PEG-PLGA block copolymer nanoparticles can adopt emulsification solvent evaporation method, precipitation method, ultrasonic method, solid dispersion-hydration method, solvent evaporation-solid melting dispersion method, thin film dispersion method, solvent evaporation method, etc.
[0029] Such as:
[0030] 1. The emulsification solvent volatilization method adopts the single milk method
[0031] The PEG-PLGA block copolymer is added to the mixed organic solvent of dichloromethane and acetone containing the model drug to form an oil phase, and this oil phase is added to the water phase composed of emulsifier and deionized water, ...
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