Microelectrode array-based multichannel neural information detection system

A microelectrode array, information detection technology, applied in the field of neurobiological detection

Active Publication Date: 2011-11-23
INST OF ELECTRONICS CHINESE ACAD OF SCI
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0003] The purpose of the present invention is to disclose a multi-channel neural information detection system based on a microelectrode array, which controls the functional arrangement of the microelectrode array through computer software to meet the r...

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  • Microelectrode array-based multichannel neural information detection system

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Embodiment Construction

[0025] The invention discloses a microelectrode array (such as Figure 4 ) multi-channel neural information detection system, which can realize bidirectional (detection and stimulation) function switching of electrodes in combination with an analog switch array, and realize dual-mode (electrophysiological and Electrochemical information) multi-channel simultaneous detection. like Figure 5 As shown, the system includes a central processing unit, a coprocessor unit, an analog switch array, a temperature monitoring circuit, a stimulation signal generating circuit, an electrophysiological detection module, an electrochemical detection module, a multi-channel parallel acquisition module, a cache circuit, and a high-speed USB communication interface, wireless bluetooth communication interface and computer software. Among them, the central processing unit is connected to the multi-channel acquisition module, the cache circuit, and communicates with the computer through the high-sp...

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Abstract

The invention discloses a microelectrode array-based multichannel neural information detection system and relates to neurobiological detection technology. The microelectrode array-based multichannel neural information detection system comprises an analogue switch array, an electrophysiological signal detection circuit, an electrochemical signal detection circuit, an electrical stimulation signal generation circuit, multiple analogue to digital (A-to-D) converter circuits, a temperature detection circuit, a high-speed universal serial bus (USB) transmission circuit, a wireless Bluetooth communication module, data processing software to be run on a computer and the like. The multichannel neural information detection system disclosed by the invention can be used for acquiring electrophysiological and electrochemical neural information of in vivo animals or in vitro tissue; and by combining with different kinds of microelectrode arrays, the multichannel neural information detection systemcan detect the electrophysiological and electrochemical signals of a plurality of neurons in a two-dimensional or three-dimensional scale, acquire more complete and accurate experimental data, and realize bidirectional and double-mode application and implementation of neurons.

Description

technical field [0001] The invention relates to the technical field of neurobiological detection, and is a detection system for simultaneously detecting the electrophysiological activities of multiple neurons and the changes of neurotransmitters. Background technique [0002] The information transmission of nerve cells is completed by pulse discharge and neurotransmitters (chemical substances). Simultaneously detecting changes in electrophysiological signals and neurotransmitter content is of great importance for studying the pathogenesis of certain diseases, nerve signal transmission, and drug responses. Scientific significance and clinical value. At the same time, the response of organisms to external events and every process of information processing requires the joint action of many nerve cells. To reveal the complex mechanism, the electrical activity information of a sufficient number of nerve cells must be obtained. Traditional electrode or single microelectrode techn...

Claims

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Application Information

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IPC IPC(8): A61B5/04G01N33/483
Inventor 林楠森蔡新霞宋轶琳刘春秀罗金平刘军涛
Owner INST OF ELECTRONICS CHINESE ACAD OF SCI
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