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A kind of preparation technology and production method of Zuojinwan integrated new dosage form

A production method and technology of a new dosage form are applied in the field of the preparation of a new integrated dosage form of Zuojin Pills, achieving the effects of strong sustained and controlled release performance and wide targeted distribution.

Inactive Publication Date: 2011-12-21
SUZHOU ZHIWEITANG BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Due to too many chemical components, the chemical reaction of compound decoction of traditional Chinese medicine has not yet been revealed its mysterious veil, but some mysterious black boxes of medicinal effects in traditional Chinese medicine prescriptions are hidden in the decoction of traditional Chinese medicine. Traditional Chinese medicine is modernized and only uses monomers and effective parts

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Prepare the following raw materials by the aforementioned method:

[0040] Extracts, nanoparticles, microcapsules, nanoparticles.

[0041] The raw materials for making the active ingredients are 6 parts of rhizoma coptis and 1 part of evodia rutaecarpa according to the weight ratio.

[0042] Its manufacturing process is as follows:

[0043] In the GMP10000 clean room, the extract, nanoparticles, microcapsules, and nanoparticles are mixed according to the ratio of 4:2:2:2, and the standards for hard capsules in the first part of the "Chinese Pharmacopoeia" of the 2010 edition are adopted, and no excipients are added. , preservatives, using a fully automatic capsule filling machine to fill hard capsules to make hard capsules. Each capsule contains not less than 40mg of berberine hydrochloride from Coptis Rhizoma. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the production...

Embodiment 2

[0045] Prepare the following raw materials by the aforementioned method:

[0046] Water decoction concentrate, nano liposome, nanoemulsion, microemulsion.

[0047] The raw materials for making the active ingredients are 6 parts of rhizoma coptis and 1 part of evodia rutaecarpa according to the weight ratio.

[0048] Its manufacturing process is as follows:

[0049] In the GMP10000 clean room, the decoction concentrate, nanoliposome, nanoemulsion, and microemulsion were mixed in a ratio of 4:2:2:2, and the standards for some soft capsules in the first part of the "Chinese Pharmacopoeia" of the 2010 edition were used. , no auxiliary materials and preservatives are added, and the soft capsules are divided into soft capsules by a fully automatic soft capsule filling machine to make soft capsules. Each capsule contains not less than 40mg of Coptidis Rhizoma and Berberine Hydrochloride. Then carry out internal and external packaging such as counting, bottling, sealing, pasting la...

Embodiment 3

[0051] Prepare the following raw materials by the aforementioned method:

[0052] Extract, nanoparticle, nanoemulsion.

[0053] The raw materials for making the active ingredients are 6 parts of rhizoma coptis and 1 part of evodia rutaecarpa according to the weight ratio.

[0054] Its manufacturing process is as follows:

[0055] In the GMP10000 clean room, after mixing the extract, nanoparticles, and nanoemulsions in a ratio of 4:3:3, the 2010 edition of the "Chinese Pharmacopoeia" Part I of the film preparation standard is adopted, and the film-forming material is polyvinyl alcohol. film former. Cartoning, sealing, sticking labels, printing codes, packing and other internal and external packaging. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report. The size of each film is 2-40 square centimeters, each gram contains Coptidis Rhizoma and berberine hydrochloride not less than 40mg, each film is applied for 12-72 hours...

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Abstract

The invention relates to a preparation technology of a new integrated dosage form of Zuojin Pills and a production method thereof. The raw material composition of the active ingredients is as follows: 6 parts of Coptis chinensis and 1 part of Evodia rutaecarpa. Its production process includes: supersonic jet milling, alcohol-water extraction, ultrasonic pulverization and extraction, decoction and concentration, supersonic spray drying, high-pressure emulsification, nano-grinding, nano-particle preparation, etc. The invention pays attention to the advantages of multi-synergy and multi-targeting embodied by the combination technology of nano-carriers. After large-scale production, the production cost can be greatly reduced, the product quality can be greatly improved, and the targeting and sustained release of the drug can be strengthened. It can be administered both internally and externally, and can be taken in four time periods according to the meridian flow and the flow of blood in the human body. Film-forming agents and transdermal agents can also be prepared and pasted on different parts of the human body according to the meridian flow and the flow of human Qi and blood, and can be directly absorbed through the skin.

Description

technical field [0001] The invention relates to a preparation technology of a new integrated dosage form of Zuojin Pills, and also relates to a preparation technology of a new integrated dosage form of Zuojin Pills and a production method thereof. Background technique [0002] Due to too many chemical components, the chemical reaction of compound decoction of traditional Chinese medicine has not yet been revealed its mysterious veil, but some mysterious black boxes of medicinal effects in traditional Chinese medicine prescriptions are hidden in the decoction of traditional Chinese medicine. Traditional Chinese medicine is modernized and only uses monomers and effective parts. The decoction concentrate of traditional Chinese medicine cannot be discarded, otherwise modern Chinese medicine will go astray! When the traditional Chinese medicine prescription is decocted in water, due to the high temperature when the prescription is decocted together and the complex chemical envir...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/754A61K9/00A61P1/08
Inventor 杨洪舒
Owner SUZHOU ZHIWEITANG BIOLOGICAL TECH
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