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New application of liquid paraffin as light transparency enhancer

A technology of liquid paraffin and optical transparent agent, applied in the field of optical transparency, can solve problems such as difficult to penetrate the surface of biological tissue, change the structure of biological tissue, tissue dehydration, etc., to improve penetration ability, reduce tissue deformation, and increase penetration speed Effect

Active Publication Date: 2011-12-21
NANKAI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The purpose of the present invention is to solve the problems that existing light-transparency agents cause tissue dehydration, change the structure of biological tissues, and make it difficult to pass through the surface of biological tissues, etc., and provide a new application of liquid paraffin as a light-transparency enhancer

Method used

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  • New application of liquid paraffin as light transparency enhancer
  • New application of liquid paraffin as light transparency enhancer
  • New application of liquid paraffin as light transparency enhancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The purpose of the experiment: To compare the light-transparency effect of the mixed solution of liquid paraffin and water-soluble light-clearing agent mixed in different proportions with the pure water-soluble light-clearing agent.

[0038] Experimental materials: In this embodiment, a mixed solution of liquid paraffin and glycerin is taken as an example for illustration. Prepare glycerol solutions with volume concentrations of 10%, 20%, 30%, 40%, 50%, 60% and 70% of liquid paraffin in the mixed solution respectively, and their corresponding volume ratios of liquid paraffin and glycerol are 1:9 , 2:8, 3:7, 4:6, 5:5, 6:4, and 7:3. Mix well. In order to obtain accurate light transparency test results over time, isolated rat skin was used as the test sample. Rats are adult rats with a body weight of about 500 grams.

[0039] Experimental method: Each concentration of liquid paraffin glycerol solution (hereinafter referred to as the mixed solution) was tested for 5 samp...

Embodiment 2

[0043] The purpose of the experiment: to test the change of the thickness of the sample over time after the mixed solutions of different concentrations are applied to the sample, reflecting the dehydration and deformation of the biological tissue.

[0044] Experimental materials: prepare the same mixed solution as in Example 1. The test sample is isolated rat skin. Rats are adult rats with a body weight of about 500 grams.

[0045] Experimental method: In order to simulate the in vivo environment of biological organisms, the sample is soaked in physiological saline, which can effectively prevent water loss caused by air, so that the thickness change is mainly caused by the reagent itself. After the reagent is coated, the distance between the focusing lens 2 and the translation stage 4 of the optical coherence tomography testing system is kept constant. The experimental test method is the same as that in Example 1. A set of optical coherence tomography images over time are ob...

Embodiment 3

[0049] Purpose of the experiment: In order to visually show the light-transparency effect after applying the mixed solution, this example gives the optical coherence tomography image of the sample coated with 40% liquid paraffin glycerol solution over time and the optical coherence of the sample without the reagent. Tomographic image.

[0050] Experimental material: 40% liquid paraffin in glycerol solution. The test sample is still isolated rat skin. Rats are adult rats with a body weight of about 500 grams.

[0051] Experimental method: with embodiment 1.

[0052] Experimental results and conclusions: The experimental results are attached Figure 4 . in, Figure 4 (a) is an optical coherence tomography image of a sample not coated with reagents, Figure 4 (b)-4(e) are optical coherence tomography images of samples collected 10 min, 20 min, 30 min, and 40 min after coating the 40% mixed solution, respectively. It can be seen from these images that, compared with Figure ...

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Abstract

The invention discloses novel application of whiteruss as an optical transparency reinforcing agent. The whiteruss as the optical transparency reinforcing agent is mixed with a water-soluble optical transparent agent; then mixture is coated on the surface of a sample to be tested; by using the synergism between the moisture preservation and high osmosis and dehydration of the water-soluble optical transparent agent on biological tissues, the refractive index distribution inside the biological tissues can be smoothened, the deformation of a biological tissue structure is reduced, the scatter of the biological tissues on light is reduced, the detection depth in the biological tissues and the strength of internal transmission, scattering or reflecting of optical signals are improved by usingan optical detection method and more information from the inside of the tissues can be acquired. According to the invention, the application of the optical detection method to the field of biomedicine and clinical or non-clinical researches is promoted.

Description

technical field [0001] The invention relates to light transparency technology, in particular to the new use of liquid paraffin as a light transparency enhancer to improve the detection depth of optical detection methods in biological tissues. Background technique [0002] Optical detection methods, such as spectral measurement, polarization imaging, confocal imaging, fluorescence measurement and optical coherence tomography, compared with medical detection technologies such as X-ray computed tomography (X-CT), nuclear magnetic resonance (MRI) and ultrasound , has unique advantages in terms of safety, cost, and optical properties exhibited by the interaction of light and biological tissue in terms of sensitivity and resolution. However, due to the complex morphological structure of biological tissue and the refractive index changes of internal components, biological tissue exhibits strong multiple scattering of input light, especially in the optical window of visible and nea...

Claims

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Application Information

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IPC IPC(8): A61K49/00
Inventor 梁艳梅王静怡张舒李燕倪海洋
Owner NANKAI UNIV
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