Scopolamine hydrobromide injection and production technology

A technology of scopolamine and hydrobromic acid, which is applied in the field of preparation of scopolamine hydrobromide injection, can solve the problems of unstable content of finished products, decreased utilization rate of raw materials, etc., and achieve the effects of stable content of finished products and improving utilization rate of raw materials

Active Publication Date: 2012-03-07
HENAN FUREN HUAIQINGTANG PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, scopolamine hydrobromide is easily adsorbed by medicinal charcoal, and the current preparation method of scopolamine hydrobromide in

Method used

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Embodiment Construction

[0014] The scopolamine hydrobromide injection provided by the invention is made up of scopolamine hydrobromide, sodium chloride, medicinal charcoal and fresh water for injection; wherein every 1000ml of the scopolamine hydrobromide injection contains 0.3g scopolamine hydrobromide, 9g Sodium chloride, 0.5g medicinal charcoal, and the rest of the ingredients are fresh water for injection.

[0015] The production technology of Scopolamine Hydrobromide Injection comprises the following steps:

[0016] Bottle sorting→washing, drying, bottle extinguishing→preparation→filling→sterilization, leak detection→light inspection→packaging→storage.

[0017] 1. Washing, drying, and extinguishing the bottle: the cleaned bottle is placed in a bottle washing machine, rough washed with purified water (water temperature 50°C-60°C) by ultrasonic waves, finely washed with water for injection, and placed in a tunnel oven at 300°C-320°C , Sterilization time ≥ 4 minutes.

[0018] 2. Preparation: Calc...

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Abstract

The invention discloses a preparation method of scopolamine hydrobromide injection, comprising the following steps that: (a) technology formula: each 1000 ml of scopolamine hydrobromide injection comprises 0.3 g of scopolamine hydrobromide, 9 g sodium chloride, 0.5 g of medicinal charcoal, and the balance consisting of fresh water for injection; (b) sodium chloride is added and dissolved in the water for injection, scopolamine hydrobromide is added, stirring is carried out until the scopolamine hydrobromide dissolve completely, and 1 mol/L of hydrobromic acid is used to adjust the pH value of the liquid medicine to 3.4-3.6; (c) the medicinal charcoal is added in the liquid medicine in the step (b) with stirring for 10 min and standing for 20 min, filtering and decarburization are carried out through a titanium stick; (d) filtering is carried out on the liquid medicine in the step (c) through a 0.45 mum cartridge filter and a 0.22 mum cartridge filter; and (e) the intermediate products are filled and sealed, then putting the filled and sealed products in a sterilization cabinet, and sterilization is carried out through circulating steam with the temperature of 100 DEG C for 30 min. According to the invention, the utilization rate of raw material is raised, and the prepared products have stable content of finished product.

Description

technical field [0001] The present invention relates to the preparation method of medicine, specifically a kind of preparation method of scopolamine hydrobromide injection. Background technique [0002] Scopolamine hydrobromide injection is a kind of anticholinergic drug with strong peripheral effect, which blocks M-choline receptors. The peripheral effect of this product is stronger than that of atropine and the maintenance time is shorter. It can inhibit gland secretion, relieve capillary spasm, improve microcirculation, dilate bronchi, and relieve smooth muscle spasm; it has sedative, hypnotic and respiratory center excitatory effects on the cerebral cortex. Clinically, it is often used for administration before anesthesia, parkinsonism, motion sickness, manic psychosis, spasm of gastrointestinal, gallbladder and renal smooth muscle, hypersecretion of gastric acid, septic shock and organophosphate pesticide poisoning. [0003] But scopolamine hydrobromide is easily adsor...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/46A61P23/00A61P25/18A61P21/02A61P1/04A61P31/00A61P39/02A61P5/00A61P9/14A61P9/00A61P11/08A61P25/20A61P11/16A61P1/06
Inventor 白宗锋朱永杰李新
Owner HENAN FUREN HUAIQINGTANG PHARMA
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