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Applications of extracts from Chinese herbal medicine Oroxylum indicum in preparation of slimming and lipid lowering medicine or preparation of medicine with inhibition effect on activity of lipase

A technology of wood butterfly and Chinese herbal medicine, which is applied in the application field of Chinese herbal medicine wood butterfly extract in the preparation of weight loss and lipid-lowering drugs or drugs with lipase activity inhibition, which can solve the problem that Chinese herbal medicine cannot go to the world, the pharmacological mechanism is unclear, and Chinese herbal medicine Issues such as unclear active ingredients

Inactive Publication Date: 2012-03-07
BEIJING WBL PEKING UNIV BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to limitations such as unclear active ingredients and pharmacological mechanisms of Chinese herbal medicines, traditional Chinese herbal medicines cannot go to the world. So far, there is no weight-loss drug with independent intellectual property rights in my country.

Method used

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  • Applications of extracts from Chinese herbal medicine Oroxylum indicum in preparation of slimming and lipid lowering medicine or preparation of medicine with inhibition effect on activity of lipase
  • Applications of extracts from Chinese herbal medicine Oroxylum indicum in preparation of slimming and lipid lowering medicine or preparation of medicine with inhibition effect on activity of lipase
  • Applications of extracts from Chinese herbal medicine Oroxylum indicum in preparation of slimming and lipid lowering medicine or preparation of medicine with inhibition effect on activity of lipase

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Embodiment 1: the preparation of Scutellaria baicalensis water extract

[0061] Take Scutellaria baicalensis slices, prefabricate, pulverize; add 5 times the volume of deionized water, boil for 30 minutes, filter, and take the filtrate; use conventional methods to make conventional dosage forms for the preparation of lipase inhibitors.

Embodiment 2

[0062] Example 2: Preparation of Scutellariae Alcohol Extract

[0063] Scutellaria baicalensis slices are taken, prefabricated, and pulverized; 5 times the volume of 75% ethanol is added, ultrasonically extracted for 60 minutes, filtered, and the filtrate is obtained; conventional dosage forms are prepared by conventional methods for the preparation of lipase inhibitors.

Embodiment 3

[0064] Embodiment 3: the preparation of Pu'er tea water extract

[0065] Take Pu'er tea decoction pieces, prefabricate, pulverize; add 10 times the volume of deionized water, boil for 60 minutes, centrifuge at 4000r / min for 20 minutes, and take the supernatant; use conventional methods to make conventional dosage forms for the preparation of lipase inhibitors.

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Abstract

The invention discloses applications of a water extract or an alcohol extract from a Chinese herbal medicine Oroxylum indicum in the preparation of a slimming and lipid lowering medicine or the preparation of a medicine with the inhibition effect on the activity of a lipase. According to the invention, shortages of low efficiency and large side effect of present clinic slimming medicines, especially traditional Chinese medicines, are solved, and the slimming and lipid lowering medicine with the advantages of clear mechanism, scientific target, small side effect and high clinical efficiency isprovided.

Description

technical field [0001] The invention relates to the application of the extract of the Chinese herbal medicine Oryza chinensis in the preparation of weight-loss and lipid-lowering medicine or the medicine with lipase activity inhibitory effect. Background technique [0002] Metabolic syndrome (MS) mainly includes risk factors such as obesity, impaired glucose tolerance, dyslipidemia, and hypertension. The incidence of diabetes (Diabetes mellitus, DM) and cardiovascular disease in MS patients is often several times that of the normal population. MS has seriously endangered human's physical and mental health and has become a worldwide public health problem, but so far our understanding of MS is very limited. Preliminary studies have confirmed that among many causes, obesity has a particularly close relationship with MS, and is a key factor and core link in the onset and development of MS. With the development of economy, the improvement of people's living standard and the cha...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K36/195A61K36/288A61K36/40A61K36/48A61K36/704A61K36/804A61K36/855A61K45/00A61P3/04A61P3/06
Inventor 段震文郭树仁闫雪秋
Owner BEIJING WBL PEKING UNIV BIOTECH
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