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Preparation method of soluble strontium citrate

A technology of soluble citric acid and citric acid, which is applied in the field of biochemical medicine and food, and can solve the problems of difficult absorption and limited use of human body and animals

Inactive Publication Date: 2012-03-14
SHANDONG HENGTONG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002]In today’s biochemical, pharmaceutical and food markets at home and abroad, strontium supplementation drugs are commonly used to treat bone hyperplasia, ricket disease and other diseases, and the ingredients of strontium supplementation drugs are mostly slightly soluble citric acid Strontium, English name: Strontium citrate, molecular formula: C6H6O7Sr, molecular content: 277.73, strontium content: 14.69% , because it is slightly soluble in water, it is not easily absorbed by humans and animals, and its use is limited

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1: Mix citric acid, strontium carbonate, and water according to the ratio of 3.32:2.76:1.07; put them into a reaction kettle with a temperature of 60 degrees after mixing, start the chemical reaction for 240 minutes; stand still for 60 minutes, the chemical reaction is mature; Stir in the reaction kettle for 70 minutes to release strontium citrate at the crystallization temperature; filter, dry and pack the finished product.

[0013] Combined with industry standards, the inspection of the finished products is evenly qualified,

[0014] The specific test results are:

[0015] project index result content% ≥98.5-105.0 99.3 Solubility ≥95% 97% acidity meet the requirements meet the requirements Loss on drying% ≤6.5 0.36 Alkalinity meet the requirements meet the requirements Iron salt% ≤0.005 0.0003 Lead salt% ≤0.0001 0.0006 Arsenic salt% ≤0.0002 0.0001

Embodiment 2

[0016] [0009] Example 2: Mix citric acid, strontium carbonate, and water according to the ratio of 3.6: 2.9: 1.3; after mixing, put it into a reactor with a temperature of 80 degrees, start the chemical reaction for 180 minutes; stand still for 50 minutes, the chemical reaction is mature; Stir in the reaction kettle for 60 minutes to release strontium citrate at the crystallization temperature; filter, dry and pack the finished product.

[0017] Combined with industry standards, the inspection of the finished products is evenly qualified.

[0018] Soluble strontium citrate can be made into chewable tablets, tablets, granules, capsules, oral liquids, and injections according to actual conditions, and should be sealed and stored in a dry and cool place away from light.

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Abstract

The invention relates to a preparation method of soluble strontium citrate in the field of biochemical and pharmaceutical foods. The technical scheme comprises the following steps of: uniformly mixing citric acid, strontium carbonate and water according to a mixing ratio; putting the uniformly mixed materials into a reaction kettle at 60-80 DEG C; starting up to carry out chemical reaction for 180-240 minutes; standing for 50-60 minutes until the chemical reaction is mature; stirring the materials in the reaction kettle for 60-70 minutes; discharging soluble strontium citrate at the crystallization temperature; filtering and drying the soluble strontium citrate; and then packaging the soluble strontium citrate to obtain a finished product. The preparation method of soluble strontium citrate, provided by the invention, has the following advantages that: the combined soluble strontium citrate with chemical structure molecular formula of Sr3(C6H5O7)2(H2CO3)3, which is white crystal powder, is a food feed additive medicine capable of treating osteoporosis and osteomalacia, easily absorbed by human and animals and used for preventing soluble strontium citrate injections and soluble strontium citrate oral liquids from being restricted by insoluble strontium citrate.

Description

technical field [0001] The invention relates to a preparation method of soluble strontium citrate in the field of biochemical industry, medicine and food. Background technique [0002] In today's biochemical, pharmaceutical and food markets at home and abroad, strontium supplementation drugs are commonly used to treat bone hyperplasia, ricket disease and other diseases. The ingredients of strontium supplementation drugs are mostly slightly soluble strontium citrate. 6 h 6 o 7 Sr, molecular content: 277.73, strontium content: 14.69%, because it is slightly soluble in water, it is not easily absorbed by humans and animals, and its use is restricted. Contents of the invention [0003] The purpose of the present invention is to provide a method for preparing soluble strontium citrate that has high solubility and is easily absorbed by humans and animals. [0004] Technical solution: consists of the following steps: [0005] Raw materials and proportioning: Mix citric acid,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C59/265C07C51/41
Inventor 王元达
Owner SHANDONG HENGTONG BIOTECH
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