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Traditional Chinese medicine composition used for treating fractures, preparation method thereof, and application thereof

A technology for treating fractures and compositions, which is applied in the field of traditional Chinese medicine compositions for treating fractures and its preparation, can solve the problems that patients cannot receive treatment, the risk of endometrial cancer, and the long-term curative effect is uncertain, so as to shorten the healing time and achieve a big society Benefit and economic benefit, definite curative effect

Inactive Publication Date: 2013-07-10
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A large number of studies have shown that estrogen replacement therapy (ERT) is the first choice for preventing and treating postmenopausal OP and preventing fractures, but long-term use of estrogen drugs has the potential risk of breast cancer and endometrial cancer, so some Patients who are unable to receive treatment due to contraindications or are reluctant to receive ERT due to concerns
Other drugs, such as calcitonin, fluoride, etc., are either expensive or have uncertain long-term efficacy, so the effect is not satisfactory

Method used

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  • Traditional Chinese medicine composition used for treating fractures, preparation method thereof, and application thereof
  • Traditional Chinese medicine composition used for treating fractures, preparation method thereof, and application thereof
  • Traditional Chinese medicine composition used for treating fractures, preparation method thereof, and application thereof

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Experimental program
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Effect test

Embodiment 1

[0029] Embodiment 1: the preparation of capsule.

[0030] According to the raw material ratio in Table 1 and the conventional method of capsule dosage form, it is prepared into capsules, and the specific methods are as follows:

[0031] Take 10g of Salvia miltiorrhiza, 10g of angelica, and 8g of safflower, add 70% ethanol 10 times the amount of the total amount of medicinal materials to reflux each time, reflux twice for 2 hours each time, combine the alcohol extracts, recover ethanol under reduced pressure, and obtain alcohol extraction Concentrated liquid: combine the dregs of the above three medicinal materials of Danshen, Angelica, and Safflower with ethanol extraction, 10g of Drynaria fortunei, 20g of Dipsacus and 14g of Achyranthes bidentata, add 20 times the amount of water each time, decoct three times, each time After 1.5 hours, combine the water decoction, concentrate to the extract with a relative density of 1.09-1.11 at 60°C, add ethanol to make the volume percenta...

Embodiment 2

[0032] Embodiment 2: Preparation of granules.

[0033] According to the ratio of raw materials in Table 1 and the conventional method of granule dosage form, it is prepared into granules, and the specific method is as follows:

[0034]Take 20g of Salvia miltiorrhiza, 15g of angelica, and 6g of safflower, and add 70% ethanol 15 times the amount of the total amount of the medicinal materials to reflux each time, reflux twice, each time for 2 hours, combine the alcohol extracts, recover the ethanol under reduced pressure, and obtain the alcohol extract Concentrated liquid: combine the dregs of the three herbs of Salvia miltiorrhiza, Angelica, and safflower with ethanol extraction, 15g of Drynaria fortunei, 15g of Dipsacus, and 12g of Achyranthes bidentata, add 20 times the amount of water each time, decoct three times, each time After 1.5 hours, combine the water decoction, concentrate to the extract with a relative density of 1.09-1.11 at 60°C, add ethanol to make the volume per...

Embodiment 3

[0035] Example 3: Preparation of tablets.

[0036] Prepare by the raw material proportioning of table 1 and tablet dosage form conventional method, be prepared into tablet, concrete method is as follows:

[0037] Take 30g of Salvia miltiorrhiza, 20g of angelica, and 4g of safflower, add 20 times the amount of 70% ethanol to reflux each time, reflux twice, each time for 2 hours, combine the alcohol extracts, recover ethanol under reduced pressure, and obtain alcohol extraction Concentrated liquid: combine the dregs of the above-mentioned three herbs of Danshen, Angelica, and Safflower with ethanol extraction, 20g of Rhizoma Drynariae, 10g of Dipsacus and 10g of Achyranthes bidentata, add 20 times the amount of water each time, decoct three times, each time After 1.5 hours, combine the water decoction, concentrate to the extract with a relative density of 1.09-1.11 at 60°C, add ethanol to make the volume percentage of the alcohol content reach 40%, leave it for 48 hours, and the...

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Abstract

The invention discloses a traditional Chinese medicine composition used for treating fractures, a preparation method thereof, and an application thereof. The traditional Chinese medicine is prepared from materials of, by weight: 10-20 parts of drynaria, 10-20 parts of radix dipsaci, 10-30 parts of salvia miltiorrhiza, 4-8 parts of safflower, 10-20 parts of ligusticum, and 10-14 parts of common achyranthes. According to the invention, salvia miltiorrhiza, safflower, and ligusticum are processed through ethanol extraction; the medicine residue obtained after ethanol extraction is mixed with drynaria, radix dipsaci and common achyranthes; the mixture is processed through water extraction and alcohol precipitation; the obtained solutions are combined, and the mixture is processed through spray-drying; and the product is prepared into corresponding preparations. The invention provides the application of the traditional Chinese medicine composition in preparing medicines used for treating fractures, and especially osteoporotic fractures.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating fractures, a preparation method and application thereof. Background technique [0002] Fracture refers to a disease in which bone is partially or completely broken due to trauma or pathology. The main clinical manifestations are: localized pain and tenderness at the fracture site, local swelling and ecchymosis, or complete loss of limb function, and limb deformity and abnormal activities in complete bone. [0003] At present, Western medicine mostly adopts infusion plus antibacterial and anti-inflammatory drugs (such as penicillin) for treatment, and the integration and reset mainly rely on self-recovery, conservative treatment, and even surgical treatment to bring pain and economic burden to the patient. There are many types of traditional Chinese medicines for treating fractures that can ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61P19/08A61P19/10
Inventor 陆兔林杭柏亚毛春芹谈瑄忠许惠琴殷放宙陈军左文胡俊扬
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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