Treatment of metastatic tumors

A technology for tumors and primary tumors, applied in the direction of antineoplastic drugs, radioactive carriers, medical preparations of non-active ingredients, etc.

Inactive Publication Date: 2012-05-02
MORPHOTEX INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The treatment and diagnosis of these metastatic tumors is a challenge due in part to the number of metastases that can form and the distance the metastases travel from the primary tumor site

Method used

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  • Treatment of metastatic tumors
  • Treatment of metastatic tumors
  • Treatment of metastatic tumors

Examples

Experimental program
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specific Embodiment approach

[0075] As mentioned above, the present invention is directed to methods for treating and / or detecting tumor metastasis. The methods provided herein generally comprise administering a chlorotoxin agent that is either labeled with a detectable moiety or not labeled with a detectable moiety. In certain embodiments, the chlorotoxin agent binds to tumor metastases. In certain embodiments, chlorotoxin agents inhibit and / or reduce the likelihood of new metastases forming. In certain embodiments, the chlorotoxin agent is administered systemically (eg, intravenously), and / or the chlorotoxin agent crosses the blood / brain barrier. Accordingly, in some embodiments, the present invention provides methods of treating, inhibiting and / or detecting metastases located in the brain. In certain embodiments, the formation of new blood vessels is inhibited and / or existing neovasculature is regressed.

[0076] In accordance with the present invention, molecular biology, microbiology and recombina...

example 1

[0210] Example 1: Chlorotoxin binding to brain and lung metastatic melanoma

[0211] The experiments described in this example demonstrate that, in biopsies, chlorotoxin binds to melanomas that have metastasized to the brain and / or lung.

[0212] Materials and Methods

[0213] Histochemical staining of frozen or paraffin sections of human biopsy tissue with a chemically synthesized chlorotoxin (TM-601) containing a detectable biotin group chemically attached to the N-terminus. Human tissue samples were from both sexes and different ages and races. Most samples were obtained through the Cooperative Human Tissue Network, UAB (University of Alabama at Birmingham) Tissue Procurement, UAB Hospital and Human Brain in London, Canada Obtained from Human Brain Tissue Bank. Snap-frozen and fresh tissues embedded in cryogels were sectioned into 8 micron slices and picked onto positively charged glass slides. Subsequently, these sections were fixed in 4% paraformaldehyde or Milloniqs ...

example 2

[0219] Example 2: Intravenous Intravenous In Patients With Relapsed or Refractory Body and / or Brain Metastatic Solid Tumors 131 A phase I imaging and safety study of I-TM-601.

[0220] This example describes preliminary results from a phase I trial conducted at 5 clinical sites. In this clinical trial, TM-601 was administered intravenously to 48 patients. This multicenter, open-label, non-randomized serial "within-subject" incremental study included patients with histologically confirmed malignant primary solid tumors (relapsed or Clear evidence of detectable metastases affected by standard therapy.

[0221] The purpose of the Phase I study is to: a) evaluate intravenous 131 I-Can TM-601 localize tumor-specifically in patients with relapsed or refractory metastatic (including brain metastases) solid tumors; b) determine the efficacy of intravenous administration 131 Distribution and dose determination of I-TM-601; and c) determination of intravenous administration 131 Saf...

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Abstract

The present invention is directed to methods and methods for the treatment, inhibition and / or reduction, and detection of metastatic tumors. In some embodiments, the inventive methods include systemic (e.g., intravenous) administration of a chlorotoxin agent that may or may not be labeled. In some embodiments, the inventive methods allow treatment, inhibition and / or reduction, and detection of metastases in the brain. In some embodiments, neovascularization is inhibited and / or newly formed vessels are caused to regress.

Description

[0001] Related Application Information [0002] This application claims U.S. Provisional Application Nos. 61 / 053,651 (filed May 15, 2008), 61 / 153,273 (filed February 17, 2009), and 61 / 173,121 (filed April 27, 2009) application), the contents of each application are incorporated herein by reference in their entirety. Background technique [0003] The ability of cancer cells to spread, or metastasize, is considered the most deadly aspect of cancer. Cancer cells can break away from the primary tumor and travel to other parts of the body via the bloodstream and / or lymphatic system, forming distant metastases. The treatment and diagnosis of these metastatic tumors is a challenge due in part to the number of metastases that can form and the distance the metastases travel from the primary tumor site. The most common metastatic sites include lung, bone, liver, and brain. Metastases localized in the brain pose a different problem than metastases that develop in other organs of the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61K47/48A61K51/08A61P35/04
Inventor 艾利森・奥尼尔道格拉斯・B・雅各比阿卜杜拉・森蒂斯卡马拉・克萨万E・迈克尔・伊根
Owner MORPHOTEX INC
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