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Multidimensional equivalent line graph method for detecting interaction mode of binary mixture

A mixture and equivalent technology, applied in the field of potentiogram method, can solve the problems of limited number of experiments, single concentration level, and inability to fully study the concentration ratio-dependent deviation and concentration-level dependent deviation of binary mixtures, so as to ensure the significance, The effect of reducing experimental error

Inactive Publication Date: 2014-07-16
TONGJI UNIV
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Problems solved by technology

[0009] Aiming at the disadvantages of the traditional experimental design scheme in which the concentration ratio and concentration level of the mixture components are single, the number of experiments is limited, and it is impossible to fully study the concentration ratio dependence deviation and concentration level dependence deviation between the components of the binary mixture, the purpose of the present invention is to provide a A direct equipartition ray method combined with an isobologram method, a multidimensional isobologram method for studying interaction modes of binary mixtures

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  • Multidimensional equivalent line graph method for detecting interaction mode of binary mixture
  • Multidimensional equivalent line graph method for detecting interaction mode of binary mixture
  • Multidimensional equivalent line graph method for detecting interaction mode of binary mixture

Examples

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Embodiment 1

[0031] The study on the interaction between dichlorvos (DIC) and ionic liquid 1-Butyl-3-methylimidazolium tetrafluoroborate (BMTF) using the multidimensional equivalent diagram method includes the following steps:

[0032] (1) Determination by conventional microplate toxicity analysis method (Ge Huilin, Liu Shushen, Liu Fang. Inhibitory toxicity of multi-component aniline mixtures to luminescent bacteria. Acta Ecotoxicology [J]; 2006; 1: 295-302) The two effect concentrations EC25 and EC50 of dichlorvos (DIC) are respectively: 5.64E-4mol / L and 1.42E-3mol / L. The two effect concentrations EC25 and EC50 of the ionic liquid 1-Butyl-3-methylimidazoliumtetrafluoroborate (BMTF) are respectively : 7.42E-3mol / L, 1.31E-2mol / L. A two-dimensional concentration coordinate plane was constructed with BMTF concentration as the abscissa (X axis) and DIC concentration as the ordinate (Y axis).

[0033] (2) According to the BMTF and DIC concentration coordinate plane, mark the EC50 of the two c...

Embodiment 2

[0038] The study on the interaction between dichlorvos (DIC) and ionic liquid 1-Ethyl-3-methylimidazolium chloride (EMC) using the multidimensional equivalent diagram method includes the following steps:

[0039] (1) Determination by conventional microplate toxicity analysis method (Ge Huilin, Liu Shushen, Liu Fang. Inhibitory toxicity of multi-component aniline mixtures to luminescent bacteria. Acta Ecotoxicology [J]; 2006; 1: 295-302) The two effect concentrations EC25 and EC50 of dichlorvos (DIC) are respectively: 5.64E-4mol / L and 1.42E-3mol / L. Determination of the two effect concentrations EC25 and EC50 of ionic liquid 1-Ethyl-3-methylimidazolium chloride (EMC) respectively It is: 2.20E-04mol / L, 3.11E-04mol / L. The concentration is the abscissa (X axis), and the DIC concentration is the ordinate (Y axis) to construct a two-dimensional concentration coordinate plane.

[0040] (2) According to the EMC and DIC concentration coordinate planes, mark the EC50 of the two component...

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Abstract

The invention discloses a multidimensional equivalent line graph method for detecting interaction mode of a binary mixture, belonging to the field of environmental pollutant toxicity detection methods. The method disclosed by the invention comprises the following steps: determining an equational design mixing mode of binary mixture components; measuring the toxic effect of the binary mixture of a fixed concentration ratio; carrying out effect concentration decomposition on the binary mixture, and drawing a multidimensional equivalent line graph; and judging the interaction mode between the binary mixture components. The method disclosed by the invention is beneficial to researching the concentration ratio between the binary mixture components as well as the concentration level dependence deviation, and researching the type of interaction of the binary mixture in the whole concentration ratio and concentration level space.

Description

technical field [0001] The invention belongs to the field of toxicity analysis of environmental pollutants, and in particular relates to a multidimensional isobologram method for detecting the interaction mode of binary mixtures of environmental pollutants. Background technique [0002] With the continuous development of modern industry, environmental pollution is becoming more and more serious, especially the pollution of chemicals. People are exposed every day to a mixture of various environmental pollutants, rather than a single pure pollutant. The mixed exposure of multi-component environmental pollutants, especially low-dose mixed exposure is a common law. More and more facts show that the cumulative and joint toxicity produced by low-dose mixed pollutants has potential environmental and health risks. As we all know, for individual pure pollutants, people have accumulated a large amount of useful data, and established reduction and control standards, so that biologica...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G06F19/00
Inventor 窦容妮刘树深朱祥伟袁静
Owner TONGJI UNIV