Application of teprenone in preparing medicine used for preventing and/or treating depression

A technology for teprenone and depression, which is applied in the field of medicine and achieves the effects of low price, significant curative effect and economic burden reduction.

Inactive Publication Date: 2014-07-30
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Whether teprenone can be used for the prevention and / or treatment of depression has not been reported

Method used

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  • Application of teprenone in preparing medicine used for preventing and/or treating depression
  • Application of teprenone in preparing medicine used for preventing and/or treating depression
  • Application of teprenone in preparing medicine used for preventing and/or treating depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: The experiment that teprenone protects cells from dexamethasone toxicity

[0018] The initial density of PC12 cells was 5 × 10 4 cell / well. The experiment was divided into three groups, namely: blank control group: no drug was added to the cell culture system; dexamethasone alone group: only 100 nM dexamethasone (Dex) was added to the cell culture system; GGA pretreatment group : Add GGA (0.1 μM, 1 μM, 10 μM, 100 μM) for pretreatment for 4 hours, then add 100 nM dexamethasone (Dex), and after the cells of the above groups continue to culture for 24 hours, use tetrathiazolium blue (MTT) experiment Check cell viability. Long-term use of dexamethasone (Dex) can lead to excitatory or inhibitory performance. Dexamethasone stimulates nerve cells and produces toxicity to nerve cells. It is a cellular model of depression. 1 The results show that when dexamethasone acts alone, it will lead to a decrease in the activity of PC12 cells (* p p <0.05, compared with ...

Embodiment 2

[0019] Embodiment 2: mouse forced swimming experiment

[0020] The graduated cylinder (20 cm high, 14 cm in diameter) used in the experiment was filled with tap water at 20°C to 22°C, and the height was 10 cm; the mice were divided into 3 groups, 7 mice in each group, and the control group (saline) was administered orally for 5 consecutive days Normal saline was given; the gum arabic group (Gum) was given 5% gum arabic by intragastric administration for 5 consecutive days; the GGA group was given GGA (teprenone dissolved in 5% gum arabic, 200 mg / kg) by intragastric administration for 5 consecutive days . The mice were gavaged continuously for 5 days, put into a graduated cylinder 2 hours after the last gavage, stayed for 6 minutes, and recorded the immobility time of the last 4 minutes. Criteria for judging immobility: stop struggling, float without moving, and only do some movements that must keep its head above the water surface. figure 2 The results showed that preperfus...

Embodiment 3

[0021] Embodiment 3: Mouse tail suspension experiment

[0022] A self-made tail suspension device is used (the wooden pole is 1 meter long, and it is placed horizontally and fixed at a position 30 cm away from the tabletop). The mice were divided into 3 groups, with 7 mice in each group. The control group (saline) was given normal saline by intragastric administration for 5 consecutive days; the gum arabic group (Gum) was given 5% gum arabic by intragastric administration for 5 consecutive days; GGA (teprenone dissolved in 5% gum arabic, 200 mg / kg) was given by intragastric administration every day. Two hours after the last gavage, the mouse was fixed on a horizontal rod 2 cm away from the tip of its tail with adhesive tape, so that it was in an upside-down state, and its head was about 8 cm away from the table. Hang for 6 minutes, and record the immobility time of the last 4 minutes. Criteria for judging immobility: cessation of struggling, inverted pituitary position, no b...

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Abstract

The invention discloses an application of teprenone in preparing a medicine used for preventing and / or treating depression. The invention belongs to the technical field of medicines. According to the invention, as a result of experiments, teprenone can protect nerve cells from the poisoning of dexamethasone, and assists in resisting mice disappointment behaviors. With teprenone, mice swim motionless time and mice tail suspension motionless time are substantially reduced. Teprenone is advantaged in substantial treatment effect, high safety, and low cost.

Description

technical field [0001] The invention relates to the use of teprenone, in particular to the application of teprenone in the preparation of drugs for preventing and / or treating depression, and belongs to the technical field of medicine. Background technique [0002] Depression is a type of mental illness that seriously endangers human physical and mental health. Its typical symptoms are low emotion, slow thinking, and decreased speech and movement. With the continuous acceleration of people's life rhythm, the increasingly fierce social competition, and the increase of various stress factors, depression is gradually becoming a common and frequently-occurring disease. According to the latest data from the World Health Organization, it is estimated that by 2020, depression will become the second largest killer of humans after cardiovascular and cerebrovascular diseases. Depression seriously affects people's quality of life and work efficiency, and even endangers the lives of pat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/121A61P25/24
Inventor 白洁郭斌罗富成周小爽吕涛
Owner KUNMING UNIV OF SCI & TECH
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