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Application of 5'-hydroxyl alternariol to preparation of medicament or cosmetic with antioxidant activity

A technology of hydroxyalternaria, antioxidant activity, applied in the application field of medicine or cosmetics, to achieve the effect of good antioxidant activity and broad application prospects

Inactive Publication Date: 2013-06-19
GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no report about the antioxidant activity of this compound

Method used

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  • Application of 5'-hydroxyl alternariol to preparation of medicament or cosmetic with antioxidant activity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Antioxidative Activity of 5'-Hydroxyalternaria Alternariol Using DPPH Free Radical Scavenging Experiment

[0013] Prepare a sample (5′-hydroxyalternaria, positive control Vc) stock solution with a concentration of 1 mM, dilute it to 40, 80, 120, 160, 200 μM with absolute ethanol; take 1.4 mg of DPPH and add 17.5 mL of anhydrous Ethanol can obtain 0.2mmol / L DPPH solution; take 100μL of the above-mentioned sample solutions of different concentrations and add them to a 96-well microtiter plate, and then add 100μL of the current DPPH solution so that the final concentration of the sample is 20, 40, 60, 80, 100 μM. Measure the absorbance value (As) of the sample at a wavelength of 517nm after the microplate plate was incubated at 30°C for 30 minutes, and measure the absorbance value (Ac) of the sample blank (100 μL absolute ethanol instead of DPPH) without DPPH free radical reagent at the same time and add DPPH Absorbance value (Amax) of free radical reagent without adding ...

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PUM

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Abstract

The invention discloses application of 5'-hydroxyl alternariol to preparation of a medicament or a cosmetic with antioxidant activity. As found by experiments, IC50 value of the 5'-hydroxyl alternariol for DPPH (2,2-diphenyl-1-picrylhydrazyl) free radial clear is 42.83 muM, the IC50 value of positive control Vc is 33.07 muM, and the free radical clear rate of the 5'-hydroxyl alternariol is equivalent to Vc. Thus, the 5'-hydroxyl alternariol has the antioxidant activity and can be used for preparing the medicament or cosmetic with antioxidant activity.

Description

Technical field: [0001] The invention relates to the fields of medicine and biotechnology, in particular to the application of the compound 5'-hydroxyalternaria in the preparation of anti-oxidative active medicines or cosmetics. Background technique: [0002] Since Harman put forward the theory of free radicals, people have gradually realized that free radicals produced by oxidation in the human body are related to human aging and many diseases. The production and removal of oxygen free radicals in the body should be balanced under normal conditions. Oxygen free radicals are by-products of aerobic biological cells during normal metabolism. 1% of the oxygen inhaled by the body every day produces oxygen free radicals. If due to some reasons, the body produces too many oxygen free radicals, or the body's ability to protect, clear and repair is reduced, the metabolism of oxygen free radicals will be imbalanced in the body, resulting in free radical damage and disease occurrence....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/366A61K8/49A61P39/06A61Q19/00
Inventor 陶美华陈玉婵章卫民
Owner GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY