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Method for preparing freeze-dried oral preparation of spina date seed decoction

An oral preparation, Suanzaoren Decoction technology, applied in freeze-dried delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of low content of active ingredients, many impurities, unstable quality, etc. The effect of storage, retention of accumulated experience, and guarantee of stability

Active Publication Date: 2012-06-13
哈药集团中药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims to solve the problems of low content of active ingredients, many impurities and unstable quality in taking Suanzaoren Decoction traditional Chinese medicine, and provides a preparation method for freeze-dried oral preparation of Suanzaoren Decoction

Method used

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specific Embodiment approach 1

[0007] Specific embodiment 1: This embodiment is a preparation method of Suanzaoren decoction freeze-dried oral preparation, which is specifically completed according to the following steps: 1. Prepare medicinal materials: weigh 15 to 18 parts of Suanzaoren, 10 parts by weight fraction Poria cocos, 3-5 parts of Chuanxiong, 8-10 parts of Anemarrhena and 3 parts of licorice; 2. Decoction: first add 15-18 parts of Suanzaoren weighed in step 1 into deionized water and decoct for 1h-1.5h, step 1 The mass ratio of 15 to 18 parts of Jujube Seed and deionized water is 1: (12 to 14), and then add 10 parts of Poria cocos, 3 to 5 parts of Chuanxiong, 8 to 10 parts of Anemarrhena and 3 licorice, and add deionized water to continue decocting for 1h to 1.5h. The total mass ratio of mother and 3 parts of licorice is (3-5): 1, and the first decoction is separated from the first decocted medicinal material by filtration, and the first decocted medicinal material obtained after separation is ad...

specific Embodiment approach 2

[0029] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the freeze-drying technology described in step 3 is staged freeze-drying, and the specific operations are: the first stage: drying at a temperature of -23°C to -25°C 60min; second stage: drying at -40℃ for 90min~120min; third stage: drying at -40℃ for 90min~120min; fourth stage: drying at -28℃~-30℃ for 60min~80min ; Stage 5: drying at a temperature of -23℃~-25℃ for 60min~80min; Stage 6: drying at a temperature of -18℃~-20℃ for 90min~120min; Stage 7: drying at a temperature of -15℃~ -17℃ drying for 300min~400min; 8th stage: drying at -11℃~-13℃ for 300min~400min; 9th stage: drying at -8℃~-10℃ for 300min~400min; 10th stage: Dry at -6℃~-8℃ for 270min~320min; Stage 11: Dry at -3℃~-5℃ for 150min~180min; Stage 12: Dry at -1℃~1℃ for 90min~ 120min; 13th stage: drying at 9℃~11℃ for 60min~80min; 14th stage: drying at 35℃ for 60min~80min; 15th stage: drying at 35℃ for 120min~140min. Others are the same ...

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Abstract

The invention discloses a method for preparing a freeze-dried oral preparation of spina date seed decoction, relates to a method for preparing a preparation, and aims to solve the problems of low active ingredient content, a large number of impurities and instable quality when a spina date seed decoction Chinese medicine is taken in the traditional method. The method comprises the following stepsof: 1, preparing spina date seed, tuckahoe, Szechuan lovage rhizome, common anemarrhena rhizome and liquoric root; 2, decocting the spina date seed in water, adding the tuckahoe, the Szechuan lovage rhizome, the common anemarrhena rhizome and the liquoric root in turn, and decocting twice; and 3, treating decoction by concentration and centrifugation methods to form clear paste, and freeze-dryingthe clear paste by a freeze-drying technology to obtain the freeze-dried oral preparation of the spina date seed decoction. The method has the advantages that: 1, an ancient prescription is followed,and the experience accumulation of the traditional medicine is kept; 2, two-time decoction is performed, so that the active ingredients of medicinal materials are kept, and the stability of a medicinal preparation is ensured; and 3, the impurities are removed by filtering and centrifugal separation means, and the oral preparation is prepared by the freeze-drying technology and is convenient to carry and store. The method is mainly used for preparing the freeze-dried oral preparation of the spina date seed decoction.

Description

technical field [0001] The invention relates to a preparation method of a preparation. Background technique [0002] Suanzaoren Decoction was first seen in "Synopsis of the Golden Chamber Blood Arthralgia Deficiency and Overuse Diseases", and it was called "Sanzao Decoction", and it was named "Sanzaoren Decoction" at the beginning of Volume 6 of "Medical Law". Consisting of 5 traditional Chinese medicines, Jujube Seed, Poria, Anemarrhena, Chuanxiong, and Licorice, it is good at nourishing blood and regulating the liver, nourishing blood and calming the nerves, clearing away heat and eliminating troubles. It is effective in the treatment of deficiency of liver blood and "consumptive fatigue and insomnia" caused by deficiency heat and internal disturbance. Suanzaoren Decoction mainly treats insomnia, palpitations, night sweats, dizziness, dry throat, dry mouth, thin and stringy pulse, restlessness and insomnia. "Jinbian Yaolue" records: "Suanzaoren Decoction is the main one ...

Claims

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Application Information

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IPC IPC(8): A61K36/8964A61K9/19A61P25/20
Inventor 刘文亮赛春梅吕晓霞秦绪江凌雪宇曲林李文春王英新李殿明
Owner 哈药集团中药有限公司
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