The invention relates to a peach seed-safflower Siwu granule originated from peach seed-safflower Siwu decoction, and a preparation method thereof. The peach seed-safflower Siwu granule is specifically characterized in that the peach seed-safflower Siwu granule is composed of six traditional Chinese medicines, i.e., peach seed, safflower, Chinese angelica, white peony root, prepared
rehmannia root and
Ligusticum wallichii; and the preparation method for the granule comprises the following process steps: crushing peach seed, safflower, Chinese angelica, white peony root, prepared
rehmannia root and
Ligusticum wallichii in proportion into
fine powder; then carrying out extraction by using a CO2
supercritical fluid extraction method; carrying out vacuum
freeze drying so as to obtain dry extract; crushing the dry extract with a
jet mill into ultrafine
powder with a particle size of less than 50 [mu]m (i.e., the ultrafine
powder can totally pass through a 300-mesh
sieve); and preparing the granule from the ultrafine
powder and pharmaceutically
adjuvant materials. According to the invention, CO2 supercritical extraction
separation technology is employed for preparing the peach seed-safflower Siwu granule originated from a classic ancient prescription of peach seed-safflower Siwu decoction; main
active components in each medicinal material of the prescription are substantially extracted, so the
active component recovery rate of the obtained granule is greatly improved; the prepared granule has the advantages of good dissolvability, a high shaping rate, small hygroscopicity and the like; and the method is easy for industrial
mass production.