Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Peach seed-safflower Siwu granule originated from peach seed-safflower Siwu decoction, and preparation method thereof

A technology of Taohong Siwu Decoction and Taohong Siwu, applied to medical preparations containing active ingredients, anti-inflammatory agents, drug combinations, etc., can solve problems such as difficult removal of organic solvents, degradation of heat-sensitive components, and complicated process steps, etc. Achieve the effects of improving medication compliance, rapid action, and improving drug stability

Inactive Publication Date: 2016-06-01
ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
View PDF7 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the process steps are complicated and time-consuming; a large amount of flammable organic solvents need to be used; heating for a long time will easily cause the degradation of heat-sensitive components and the organic solvents remaining in the extract are difficult to remove completely

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0020] Take 90 grams of peach kernels, 150 grams of rehmannia glutinosa, 150 grams of angelica, 100 grams of white peony, and 90 grams of Chuanxiong, and grind them into coarse powder, then add 60 grams of safflower and grind them into fine powder. Using CO 2 Supercritical extraction method extraction, wherein the extraction temperature is 50°C, the extraction pressure is 120Mpa, the extraction time is 2.5 hours, CO 2 The flow rate is 25kg / h, ethanol is selected as the entrainer, and the ratio is 5%; the obtained extract is concentrated to a dry paste. The extract is pumped into a vacuum concentration tank, and the ethanol is recovered at a temperature of 45°C and a vacuum of 0.08Mpa until no liquid can be seen in the extract. Pre-freeze the wet extract at -60°C for 4 hours to freeze the extract quickly, then turn on the vacuum pump, and when the vacuum degree is below 100Pa, turn on the heating, execute the temperature program to promote water sublimation, and the freeze-dry...

specific Embodiment 2

[0021] Take 110 grams of peach kernels, 150 grams of rehmannia glutinosa, 200 grams of angelica, 100 grams of white peony, and 80 grams of Chuanxiong, and grind them into coarse powder, then add 70 grams of safflower and grind them into fine powder. Using CO 2 Supercritical extraction method extraction, wherein the extraction temperature is 50°C, the extraction pressure is 120Mpa, the extraction time is 2.5 hours, CO 2 The flow rate is 25kg / h, ethanol is selected as the entrainer, and the ratio is 5%; the obtained extract is concentrated to a dry paste. The extract is pumped into a vacuum concentration tank, and the ethanol is recovered at a temperature of 45°C and a vacuum of 0.08Mpa until no liquid can be seen in the extract. Pre-freeze the wet extract at -60°C for 4 hours to freeze the extract quickly, then turn on the vacuum pump, and when the vacuum degree is below 100Pa, turn on the heating, execute the temperature program to promote water sublimation, and the freeze-dr...

specific Embodiment 3

[0022] Take 90 grams of peach kernels, 150 grams of rehmannia glutinosa, 150 grams of angelica, 100 grams of white peony, and 100 grams of Chuanxiong, and grind them into coarse powder, then add 60 grams of safflower and grind them into fine powder. Using CO 2 Supercritical extraction method extraction, wherein the extraction temperature is 50°C, the extraction pressure is 120Mpa, the extraction time is 2.5 hours, CO 2The flow rate is 25kg / h, ethanol is selected as the entrainer, and the ratio is 5%; the obtained extract is concentrated to a dry paste. The extract is pumped into a vacuum concentration tank, and the ethanol is recovered at a temperature of 45°C and a vacuum of 0.08Mpa until no liquid can be seen in the extract. Pre-freeze the wet extract at -60°C for 4 hours to freeze the extract quickly, then turn on the vacuum pump, and when the vacuum degree is below 100Pa, turn on the heating, execute the temperature program to promote water sublimation, and the freeze-dry...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a peach seed-safflower Siwu granule originated from peach seed-safflower Siwu decoction, and a preparation method thereof. The peach seed-safflower Siwu granule is specifically characterized in that the peach seed-safflower Siwu granule is composed of six traditional Chinese medicines, i.e., peach seed, safflower, Chinese angelica, white peony root, prepared rehmannia root and Ligusticum wallichii; and the preparation method for the granule comprises the following process steps: crushing peach seed, safflower, Chinese angelica, white peony root, prepared rehmannia root and Ligusticum wallichii in proportion into fine powder; then carrying out extraction by using a CO2 supercritical fluid extraction method; carrying out vacuum freeze drying so as to obtain dry extract; crushing the dry extract with a jet mill into ultrafine powder with a particle size of less than 50 [mu]m (i.e., the ultrafine powder can totally pass through a 300-mesh sieve); and preparing the granule from the ultrafine powder and pharmaceutically adjuvant materials. According to the invention, CO2 supercritical extraction separation technology is employed for preparing the peach seed-safflower Siwu granule originated from a classic ancient prescription of peach seed-safflower Siwu decoction; main active components in each medicinal material of the prescription are substantially extracted, so the active component recovery rate of the obtained granule is greatly improved; the prepared granule has the advantages of good dissolvability, a high shaping rate, small hygroscopicity and the like; and the method is easy for industrial mass production.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations. Specifically relates to a Taohong Siwu granule derived from Taohong Siwu Decoction and a preparation method thereof. Background technique [0002] Taohong Siwu Decoction is one of the classic traditional Chinese medicine prescriptions for promoting blood circulation and removing blood stasis. It was first seen in "Yi Lei Yuan Rong" quoted in "Yu Ji Wei Yi", also known as Jiawei Siwu Decoction. ·Wu Qianzhi's "Golden Mirror of Medicine" is composed of six traditional Chinese medicines: peach kernel, safflower, angelica, white peony root, rehmannia glutinosa, and chuanxiong. Taking stasis dispelling as the core, supplemented by nourishing blood and promoting qi. In the prescription, peach kernels and safflower, which are strong blood-breaking products, are mainly used to promote blood circulation and remove blood stasis; sweet and warm rehmannia root, angelica nou...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K36/804A61P9/00A61P15/00A61P15/14A61P29/00A61P37/04A61P9/10A61P3/10A61P25/02
Inventor 彭代银陈卫东韩岚
Owner ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com