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Method for preparing freeze-dried oral preparation of spina date seed decoction

An oral preparation, Suanzaoren Decoction technology, applied in the direction of freeze-dried transportation, medical formula, medical preparations containing active ingredients, etc., can solve the problems of many impurities, low content of active ingredients, unstable quality, etc., and achieve the accumulation of experience , easy to carry and store, ensure the effect of stability

Active Publication Date: 2013-07-03
哈药集团中药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims to solve the problems of low content of active ingredients, many impurities and unstable quality in taking Suanzaoren Decoction traditional Chinese medicine, and provides a preparation method for freeze-dried oral preparation of Suanzaoren Decoction

Method used

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Examples

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specific Embodiment approach 1

[0007] Embodiment 1: This embodiment is a preparation method of a freeze-dried oral preparation of Suanzaoren Decoction, which is specifically completed according to the following steps: 1. Prepare medicinal materials: weigh 15-18 parts of Suanzaoren Decoction, 10 Parts of Poria, 3 to 5 parts of Chuanxiong, 8 to 10 parts of Anemarrhena and 3 parts of licorice; 2. Decoction: First, add 15 to 18 parts of jujube seeds weighed in step 1 into deionized water and cook for 1h to 1.5h. 1. The mass ratio of 15-18 parts of Suanzaoren and deionized water is 1: (12-14), and then 10 parts of Poria, 3-5 parts of Chuanxiong, 8-10 parts of Anemarrhena and 3 parts of licorice, add deionized water and continue to cook for 1h to 1.5h, add the mass of deionized water and 15 to 18 parts of jujube seed, 10 parts of Poria, 3 to 5 parts of Chuanxiong, 8 to 10 parts of the weight of deionized water weighed in step 1 The total mass ratio of Anemarrhena and 3 parts of licorice is (3~5): 1, the first dec...

specific Embodiment approach 2

[0029] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the freeze-drying technology described in step 3 is staged freeze-drying, and the specific operations are: the first stage: drying at a temperature of -23°C to -25°C 60min; second stage: drying at -40℃ for 90min~120min; third stage: drying at -40℃ for 90min~120min; fourth stage: drying at -28℃~-30℃ for 60min~80min ; Stage 5: drying at a temperature of -23℃~-25℃ for 60min~80min; Stage 6: drying at a temperature of -18℃~-20℃ for 90min~120min; Stage 7: drying at a temperature of -15℃~ -17℃ drying for 300min~400min; 8th stage: drying at -11℃~-13℃ for 300min~400min; 9th stage: drying at -8℃~-10℃ for 300min~400min; 10th stage: Dry at -6℃~-8℃ for 270min~320min; Stage 11: Dry at -3℃~-5℃ for 150min~180min; Stage 12: Dry at -1℃~1℃ for 90min~ 120min; 13th stage: drying at 9℃~11℃ for 60min~80min; 14th stage: drying at 35℃ for 60min~80min; 15th stage: drying at 35℃ for 120min~140min. Others are the same ...

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Abstract

The invention discloses a method for preparing a freeze-dried oral preparation of spina date seed decoction, relates to a method for preparing a preparation, and aims to solve the problems of low active ingredient content, a large number of impurities and instable quality when a spina date seed decoction Chinese medicine is taken in the traditional method. The method comprises the following stepsof: 1, preparing spina date seed, tuckahoe, Szechuan lovage rhizome, common anemarrhena rhizome and liquoric root; 2, decocting the spina date seed in water, adding the tuckahoe, the Szechuan lovage rhizome, the common anemarrhena rhizome and the liquoric root in turn, and decocting twice; and 3, treating decoction by concentration and centrifugation methods to form clear paste, and freeze-dryingthe clear paste by a freeze-drying technology to obtain the freeze-dried oral preparation of the spina date seed decoction. The method has the advantages that: 1, an ancient prescription is followed,and the experience accumulation of the traditional medicine is kept; 2, two-time decoction is performed, so that the active ingredients of medicinal materials are kept, and the stability of a medicinal preparation is ensured; and 3, the impurities are removed by filtering and centrifugal separation means, and the oral preparation is prepared by the freeze-drying technology and is convenient to carry and store. The method is mainly used for preparing the freeze-dried oral preparation of the spina date seed decoction.

Description

technical field [0001] The present invention relates to a preparation method of a preparation. Background technique [0002] Suanzaoren Decoction was first seen in "The Synopsis of the Golden Chamber: Blood Arthritis Constipation", named "Suanzaoren Decoction", and "Suanzaoren Decoction" in Volume VI of "Medical Law". It is composed of 5 traditional Chinese medicines such as Suanzaoren, Poria, Anemarrhena, Chuanxiong and Licorice. Indication of liver blood deficiency, "consumptive exhaustion, irritability and insomnia" caused by deficient heat and internal disturbance has a definite curative effect. Suanzaoren Decoction treats insomnia, palpitations and night sweats, dizziness, dry throat, thin and stringy pulse, irritability and inability to sleep. It is recorded in the "Golden Plaque Synopsis": "Consumption of exhaustion and exhaustion can not sleep, Suanzaoren Tang is the master". That is to say, this recipe is for the treatment of insomnia due to deficiency and vexati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/19A61K36/8964A61P25/20
Inventor 刘文亮赛春梅吕晓霞秦绪江凌雪宇曲林李文春王英新李殿明
Owner 哈药集团中药有限公司
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