Composition of gastric mucin capsule and preparation method for composition

A technology of gastrin and composition, applied in the field of medicine, can solve problems such as cost exceeding the affordability of manufacturers, and achieve the effect of solving the problem of market supply

Active Publication Date: 2013-09-11
HEFEI JINYUE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the cost of the above process has exceeded the affordability of the manufacturer

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] components g / grain Gastrin 0.4 starch 0.02 Magnesium stearate 0.02 total weight 0.44

[0021] Preparation method: sieve gastin and starch separately, add magnesium stearate and dry mix for 10 minutes, mix evenly, fill, and obtain.

[0022] The disintegration time limit of the Gastrin Capsules prepared in this example was determined according to the relevant provisions of the appendix of the Chinese Pharmacopoeia 2010 edition: the result was 20 minutes.

Embodiment 2

[0024] components g / grain Gastrin 0.392 Magnesium stearate 0.008 total weight 0.4

[0025] Preparation method: Sieve Gastrin and add magnesium stearate, dry mix for 10 minutes, and fill directly in 1 to obtain.

[0026] The Gastrin Capsules prepared in this example were subjected to the determination of the disintegration time limit as described in Example 1: 23 minutes.

Embodiment 3

[0028] components g / grain Gastrin 0.2 dextrin 0.12 Magnesium stearate 0.08 total weight 0.4

[0029] Preparation method: Separately sieve peptin and dextrin, dry mix for 10 minutes, add 60% ethanol to make soft material, granulate, dry, granulate, add magnesium stearate, mix evenly, fill, and obtain.

[0030] The Gastrin Capsules prepared in this example were subjected to the determination of the disintegration time limit as described in Example 1: 15 minutes.

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Abstract

The invention discloses a composition of a gastric mucin capsule and a preparation method for the composition. The gastric mucin capsule is mainly prepared from 50 to 96 weight percent of gastric mucin, 2 to 30 weight percent of filling agent and 2 to 20 weight percent of regulator by a wet granulation encapsulation method or a powder direct encapsulation method. By the composition of the gastric mucin capsule and the preparation method for the composition, the problem that the gastric mucin capsule is unqualified in disintegration is solved and the problem about market supply is solved.

Description

technical field [0001] The invention relates to a composition of gasmenin capsules and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Gastrin is currently a drug on the market for the treatment of gastric and duodenal ulcers. Gastrin is a biologically active drug extracted from pig mucosa with mucin as the main component. It has a strong adhesive effect and can directly act on the inner wall of the digestive tract to form a layer on the surface of gastric and duodenal ulcers. The protective film reduces the stimulation of gastric acid, which is beneficial to the healing of the ulcer surface; on the other hand, it has a lubricating effect, which makes it easy for the food entering the digestive tract to migrate in the digestive tract, which is beneficial to reduce the stimulation of certain substances on the ulcer surface. [0003] Due to the strong viscosity of gastrin, the disintegration time limit of gastrin capsu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/00A61K35/38A61K9/48A61P1/04A61K35/57
Inventor 赵勇王旦刘延武杨波
Owner HEFEI JINYUE PHARMA
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