The invention discloses a high-strength high-toughness steel plate. The steel comprises the following chemical components in percentage by weight: 0.032-0.11% of C, 0.10-0.26% of Si, 1.51-1.80% of Mn, 0.03-0.06% of Nb, 0.012-0.020% of Ti, at most 0.052% of V, at most 0.20% of Mo, at most 0.40% of Ni, at most 0.30% of Cr, at most 0.15% of Cu, at most 0.018% of P, at most 0.0020% of S, and the balance of Fe and inevitable impurities. The invention also discloses a preparation method of the high-strength high-toughness steel plate, which comprises the following steps: 1) blank casting; 2) heating; 3) rolling; 4) cooling; 5) heat treatment; and 6) air cooling. The method has the advantages of simple hot rolling technique, low heat treatment temperature, short holding time, low energy consumption and lower production cost, obtains the product with higher quality, and enhances the yield.