Method for modifying activated carbon for blood perfusion

A technology of blood perfusion and activated carbon, applied in chemical instruments and methods, other chemical processes, etc., to achieve the effect of simple method, avoiding powder carbon particles, and easy operation

Inactive Publication Date: 2012-07-04
ZUNYI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to provide a simple method to improve the blood compatibility of gac, meanwhile, the adsorption capacity of gac obtained is changed little or even improved, In order to change the shortcomings of the existing activated carbon for hemoperfusion that the adsorption capacity drops greatly after being coated, and even cannot adsorb medium-sized molecules

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  • Method for modifying activated carbon for blood perfusion

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Experimental program
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Effect test

Embodiment 1

[0017] 80-100 mesh coal activated carbon 10g, add 3mol / L 25mL of nitric acid and treat it in a constant temperature water bath at 25°C for 10 hours, then use ultrasonic to clean the activated carbon with distilled water until the effluent reaches pH=7, then dry it. The activated carbon yield was 87%. Take 1g of activated carbon and add 50mL of water. After repeated cycles of washing with water 30 times, no obvious powder formation is seen in the water. The hemoperfusion operation of activated carbon is as follows: accurately weigh 1g of the treated activated carbon and put it into the perfusion column, first soak it with pH=7.3 sodium dihydrogen phosphate buffer solution, then rinse the perfusion column with normal saline, and finally use 30 mL of fresh blood The perfusion was performed at a flow rate of 4.0 mL / min and compared with the original activated carbon. After 40 minutes of perfusion, the results obtained are as follows:

[0018] blood White blood cells (WBC) Red b...

Embodiment 2

[0020] Effect of processing time

[0021] Take 10g of 80-100 mesh coal-based activated carbon, and add 25mL of 3mol / L nitric acid respectively, and treat them in a constant temperature water bath at 60℃ for 2, 12 and 24 hours, then wash with distilled water and ultrasonic water until the effluent reaches pH =7 After drying, the yields of activated carbon were 83, 77 and 65% respectively. Take 1g of activated carbon for hemoperfusion according to the aforementioned method, and compare it with untreated activated carbon. After 40 minutes of perfusion, the results are as follows:

[0022] blood White blood cells (WBC) Red blood cells (RBC) Platelets (PLT) Original blood4.861.7783 Perfused with original activated carbon3.291.5512 After 2h treatment activated carbon perfusion3.531.5919 After 12h treatment activated carbon perfusion3.811.6231 After 24h treatment activated carbon perfusion4.121.6447

Embodiment 3

[0024] Effect of processing temperature

[0025] Take 10g of 80-100 mesh coal-based activated carbon, and add 25mL of 6mol / L nitric acid respectively, and then treat them in a constant temperature water bath at 5, 60 and 100°C for 12 hours, and then wash with distilled water ultrasonically until the effluent After reaching pH=7, drying, the activated carbon yield is 85, 76 and 62%. Take 1g of activated carbon for hemoperfusion according to the aforementioned method, and compare with the original activated carbon. After 40 minutes of perfusion, the results are as follows:

[0026] blood White blood cells (WBC) Red blood cells (RBC) Platelets (PLT) Perfused with original activated carbon4.601.8360 Activated carbon perfusion treated at 5℃4.011.7022 Activated carbon perfusion treated at 60℃4.171.7024 Activated carbon perfusion treated at 95℃4.011.7522

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Abstract

A method for modifying activated carbon for blood perfusion comprises the following specific steps of: 1, modifying the activated carbon: washing 80-100-mesh coal activated carbon sold in the market with water to remove floating carbon, and treating the activated carbon by taking nitric acid, concentrated sulfuric acid, 30% hydrogen peroxide and a saturated ammonium persulfate solution as oxidizing and modifying agents, wherein when the nitric acid is taken as the modifying agent, the processing conditions are as follows: the temperature is 0-100 DEG C, the concentration is 0.1-12mol / L, the processing time is 2-24 hours, and the ratio of the weight of the activated carbon to the volume of an oxidizing agent is about 1g / 2.5mL; and 2, repeatedly eluting the processed activated carbon with sterile distilled water or deionized water during ultrasonic oscillation till the pH of an eluent is 7, and then drying the eluted activated carbon at the temperature of 120 DEG C and storing the activated carbon with a sterilized packaging bag in a sterile way. The method for modifying the activated carbon for the blood perfusion is simple, and easy to operate.

Description

technical field [0001] The present invention relates to the modification of activated carbon for hemoperfusion. Background technique [0002] Activated carbon is the most commonly used adsorbent in hemoperfusion. It is used to adsorb and remove toxic and harmful substances in patients with liver failure, sepsis, uremia and other diseases, as well as in patients with drug poisoning such as pesticides and sleeping pills. patient's disease or save the life of a critically ill patient. In hemoperfusion, since activated carbon is in direct contact with blood, activated carbon is required to have better hemocompatibility with blood. In addition, large adsorption capacity and no powder generation are two other important requirements for activated carbon in hemoperfusion. Among them, blood compatibility is the most critical. [0003] In hemoperfusion, general commercial activated carbon is directly used to perfuse the patient, and its hemocompatibility is poor. After use, the pat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/30B01J20/20
Inventor 钟永科谢波
Owner ZUNYI MEDICAL UNIVERSITY
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