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Angelica oncosepala linear furocoumarins compound and application thereof

A furanocoumarin and compound technology, which is applied in the direction of active ingredients of heterocyclic compounds, drug combinations, digestive system, etc., can solve problems such as no new linear furanocoumarin compounds

Inactive Publication Date: 2012-07-04
KUNMING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are no reports of two new linear furocoumarin compounds involved in the present invention in the prior art

Method used

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  • Angelica oncosepala linear furocoumarins compound and application thereof
  • Angelica oncosepala linear furocoumarins compound and application thereof
  • Angelica oncosepala linear furocoumarins compound and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Tablets: compound I 10mg lactose 180mg starch 55mg magnesium stearate 5mg.

[0059] Preparation method: mix compound I, lactose and starch, moisten evenly with water, sieve the wetted mixture and dry it, then sieve it, add magnesium stearate, then compress the mixture into tablets, each tablet weighs 250 mg, the active ingredient The content is 10 mg.

Embodiment 2

[0061] Ampoule: compound Ⅱ 2mg sodium chloride 10mg.

[0062] Preparation method: Dissolve compound II and sodium chloride in an appropriate amount of water for injection, filter the resulting solution, and fill it into an ampoule bottle under sterile conditions.

Embodiment 3

[0064] Capsules: compound Ⅱ 10mg, lactose 187mg, magnesium stearate 3mg.

[0065] Preparation method: mix compound II with auxiliary agents, sieve, mix evenly, put the obtained mixture into hard gelatin capsules, each capsule weighs 200 mg, and the active ingredient content is 10 mg.

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PUM

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Abstract

The invention relates to new compounds, in particular linear furanocoumarin compounds with antitumor activity and pharmaceutical application thereof. The general formula of an angelica oncosepala linear furocoumarins compound is shown in the description, wherein R is -H or -CH(CH3)2. The invention relates to the application of the angelica oncosepala linear furocoumarins compound in preparation of tumor cell inhibiting medicines.

Description

technical field [0001] The present invention relates to a new class of compounds, especially linear furanocoumarin compounds with antitumor activity, and their application in pharmacy. Background technique [0002] Umbelliferae (Umbelliferae) has about 275 genera and more than 2850 species in the world. It is nearly global in distribution, and the northern temperate zone is the most abundant. There are about 96 genera and 525 species in my country, and there are about 51 genera in Yunnan. There are 259 species and 21 varieties. The research on medicinal plants of the Umbelliferae family mainly began in the 1970s. The research results show that the chemical components of the medicinal plants of the Umbelliferae family are mainly coumarins, and there are four main structural types: simple coumarins Type, linear furanocoumarin type, angle type furanocoumarin type, angle type dihydropyranocoumarin type. Modern pharmacological studies have shown that umbelliferae coumarin has a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/04A61K31/37A61P35/00A61P35/02A61P1/16A61P11/00A61P15/14A61P1/00
Inventor 李鲜郑斌卿晨杨为民李军李勇张敏唐丽萍
Owner KUNMING MEDICAL UNIVERSITY
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