Compound orlistat nano-emulsion oral liquid and preparation method thereof

Abstract

The invention discloses a compound orlistat nano-emulsion oral liquid which contains the following components by mass percentage: 35%-45% of surfactant, 0-1% of cosurfactant, 0-1% of oil phase, 0.5%-4% of orlistat, 0.5%-3% of fructus cannabis oil, 0.5%-2% of evening primrose oil, 0.1%-0.5% of beta-carotene, 0.0001%-0.002% of vitamin D, 0.1%-0.5% of vitamin E, 0.0001-0.002% of vitamin K, and the balance of deionized water, and the sum of the mass percentage of the components is 100 percent. Aiming at the features of obese patients, the compound orlistat nano-emulsion oral liquid has multiple effects of reducing absorption of fat and heat in food, accelerating consumption of stubborn brown adipose tissues accumulated in the body, replenishing micronutrient matters lost during weight loss, reducing blood fat and cholesterol and the like, and does not have the side effects of insomnia, strength lack, palpitation and the like.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a compound formula for safe weight loss and a method for preparing the compound into a new dosage form, in particular to a compound orlistat nanoemulsion oral liquid and a preparation method thereof. [0002] Background technique [0003] The World Health Organization has confirmed that obesity is a disease. The number of obese patients in the world is doubling in about 5 years. At present, there are at least 200 to 500 million obese people in the world, and about 1 billion overweight people. In my country, there are about 300 million overweight people over the age of 20, and more than 40 million obese people. Obesity is often accompanied by "three highs" (high blood pressure, high blood sugar, and high blood lipids), and the incidence of "three diseases" (diabetes, heart disease, and cancer) increases. Chance. More than 80% of diabetics have a history of obesity, and more than 90% will be...

AI Technical Summary

Problems solved by technology

When it is mixed and digested with food in the gastrointestinal tract, it is difficult to distribute evenly and fully contact with the lipase in the gastrointestinal tract, resulting in high local drug concentration and causing most of the drugs to not play their role, resulting in overdose

2) Studies have shown that taking orlistat will cause the loss of fat-soluble vitamins, especially the lack of vitamins A, D, E, and K

3) During the fat reduction process, Orlistat blocks the new intake of calories and fat, and also prevents the intake of essential fatty acids in the body, resulting in fatigue, lethargy, and skin problems in weight loss patients when taking Orlistat. Adverse reactions such as dryness and developmental delay

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