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Amnion-based biological material and preparation method and uses thereof

A technology of biomaterials and amniotic membranes, applied in medical science, prosthesis, surgery, etc., to promote the differentiation of goblet cells, facilitate preparation, and reduce scar formation

Inactive Publication Date: 2012-08-15
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no related studies on the histological changes when the amniotic membrane is used to reconstruct the ocular surface

Method used

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  • Amnion-based biological material and preparation method and uses thereof
  • Amnion-based biological material and preparation method and uses thereof
  • Amnion-based biological material and preparation method and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1: Transplantation of de-epithelized amniotic membrane tissue for the treatment of ocular surface tissue epithelial cell defects

[0040] The clinical treatment of epithelial cell defects in ocular surface tissue by epithelialized amniotic membrane tissue transplantation is implemented in two ways:

[0041] First, de-epithelialized amnion tissue is used as a temporary attachment to cover the ocular surface to promote the repair of the ocular surface epithelium and reduce the degree of inflammation, inhibit scar formation, and promote goblet cell differentiation during the repair process. The specific implementation method is as follows: thaw the aseptic amnion tissue which has undergone de-epithelial treatment before operation, and temporarily store it in normal saline or any kind of balanced salt solution for later use. Balanced salt solution is used to flush the ocular surface of any kind of ocular surface epithelial cell damage diseases, such as: alkali burn,...

Embodiment 2

[0043] Example 2: Transplantation of de-epithelialized amniotic membrane tissue for the treatment of epithelial cell defects in other mucosal tissues

[0044] As in Example 1, the de-epithelialized amniotic membrane is transplanted on the ocular surface, skin, oral cavity, stomach, cervix and mucous membrane of the respiratory tract in the form of a temporary attachment or a permanent transplant substitute for the treatment of epithelial layer defect diseases.

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Abstract

The invention relates to an amnion-based biological material and a preparation method and uses thereof, and relates to a biological material. The amnion-based biological material is a de-epithelialized amniotic tissue. The preparation method of the amnion-based biological material i.e. the de-epithelialized amniotic tissue comprises the following steps that: the amniotic tissue is de-epithelialized to remove amniotic epithelial cells so as to obtain the amnion-based biological material. The amnion-based biological material can be used as a mucosal epidermis repair promoting material or epithelial cell repair promoting material so as to promote the tissue reconstruction of the ocular surface, the oral cavity, the respiratory tract, the stomach and the vaginal mucosal. The implementation process is safe, reliable and easy. The source of amnion is wide, and the de-epithelialized amnion can be conveniently prepared. The amnion transplant surgery is simple to operate and easy to implement.

Description

technical field [0001] The invention relates to a biological material, in particular to a biological material based on amniotic membrane and its preparation method and application. Background technique [0002] There are a large number of ocular surface epithelial injury diseases in clinical ophthalmology: such as: ocular chemical injury, eye thermal burn, etc.; Corneal chronic inflammatory diseases caused by etiology, whether it is a large-scale epithelial cell defect, or a systemic disease caused by epithelial cell defect, the protracted chronic course of the disease can lead to corneal ulcers or cicatricial changes, symblepharonitis Even serious consequences such as blindness. Since scholars introduced intact amniotic membrane into ophthalmology clinical treatment in the 1990s, basic and clinical research on amniotic membrane has been gradually carried out. So far, intact amniotic membrane has been proven to promote the repair of epithelial cells, and has anti-inflammat...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/54A61L31/16
Inventor 李炜刘祖国揭静杨洁
Owner XIAMEN UNIV
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