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Application of curcumin in preparing medicine for treating intestinal ischemia reperfusion injury

An ischemia-reperfusion, curcumin technology, applied in the direction of drug combination, antipyretics, non-central analgesics, etc., can solve the problem that the effect of prevention and treatment is not obvious, the mechanism of acute and critical illness is complicated, and the To achieve the expected effects and other issues, to achieve stability and further deterioration, avoid drug toxicity and side effects, and improve the effects of pathological damage

Inactive Publication Date: 2012-09-19
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although research and clinical personnel have tried many methods for the prevention and treatment of acute and critical illnesses such as intestinal ischemia-reperfusion, for example, clinically combined with fluid replacement and application of vasodilator drug therapy, heparin and antifibrinolytic system drug therapy, Anti-cytokine therapy, etc., but the practice of the past ten years has proved that they have failed to achieve the desired effect
This is because the occurrence mechanism of such acute and critical diseases is complex and regulated by various factors; the development speed is fast, and early intervention and treatment are necessary, so the clinical effect of prevention and treatment is still not very obvious

Method used

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  • Application of curcumin in preparing medicine for treating intestinal ischemia reperfusion injury
  • Application of curcumin in preparing medicine for treating intestinal ischemia reperfusion injury
  • Application of curcumin in preparing medicine for treating intestinal ischemia reperfusion injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 Curcumin treats intestinal ischemia-reperfusion injury in mice

[0023] (1) Preparation of curcumin preparation

[0024] Povidone (PVP) curcumin solid dispersion:

[0025] Mass ratio (curcumin:PVP=1:8)

[0026] Dissolve 24g of PVP in 40ml of absolute ethanol and stir with magnetic force;

[0027] Dissolve 3g of curcumin in 3ml of absolute ethanol, add dropwise to the PVP solution, wash the bottle with 10ml of absolute ethanol, stir manually, pour it into a 250ml beaker with a large rotor and stir well, freeze-dry for 4 hours after stirring, and obtain a solid dispersion of curcumin.

[0028] Curcumin solid dispersion solution:

[0029] Weigh 900mg of curcumin solid dispersion, add 5ml of normal saline for injection, that is curcumin 20mg / ml, in a brown bottle, it is transparent orange red, viscous, take 20mg / ml 1ml+ normal saline 7ml is 2.5mg / ml ml of application solution.

[0030] (2) Preparation of mouse intestinal ischemia-reperfusion injury model a...

Embodiment 2

[0033] Example 2 Effect of curcumin on intestinal pathological injury, liver and kidney function, expression of apoptosis and inflammation-related regulatory factors in mice with intestinal ischemia-reperfusion injury

[0034] (1) Effect of curcumin on pathological damage of intestinal tissue in mice

[0035] Get each group of mouse intestinal ileocecal portion more than 10cm intestinal tube after the processing of Example 1, fix through 10% neutral formaldehyde, paraffin embedding, section, carry out histological examination after hematoxylin-eosin (HE) staining, and the The degree of small intestinal tissue damage was scored.

[0036] The result is as image 3 As shown, almost no damage was observed in the sham operation group A, the intestinal tissue damage was serious in the control group B, almost all the intestinal villi fell off, and the mucosal necrosis was severe; although the intestinal tissue in the curcumin treatment group C still had necrosis, the degree was sign...

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Abstract

The invention discloses the application of curcumin in preparing a medicine for treating the intestinal ischemia reperfusion injury in the technical field of medicine preparation. According to the application of the curcumin in preparing the medicine for treating the intestinal ischemia reperfusion injury, an intestinal ischemia reperfusion injury model is prepared, and curcumin-polyvinylpyrrolidone (PVP) solid dispersions are used for treating the intestinal ischemia reperfusion injury model after being dissolved by normal saline for injection. The therapeutic effect of the curcumin is detected through gross tissue observation, disease model death rate, histopathological changes, serum liver and renal function changes and changes of apoptosis and inflammation-related regulatory factors in tissues. According to results, the intestinal ischemia reperfusion injury can be effectively treated by the curcumin, and a basis is provided for the application of the curcumin in emergency and critical symptoms.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to the application of curcumin in the preparation of medicine for intestinal ischemia-reperfusion injury. Background technique [0002] Curcumin is a chemical component extracted from some plant rhizomes in Zingiberaceae and Araceae. It is a rare pigment with diketones in the plant kingdom. It has the functions of dispelling blood and promoting qi, dredging menstruation and relieving pain. The main components of curcuminoids are curcumin, demethoxycurcumin and bisdemethoxycurcumin. At present, domestic and foreign studies have proved that curcumin is not only a natural nutrient, but also has the traditional effects of turmeric, but also has anti-inflammatory, anti-oxidation, scavenging oxygen free radicals, anti-human immunodeficiency virus, anti-cancer, anti-cancer, and liver protection. And new pharmacological effects such as kidney and anti-fibrosis. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61P1/00A61P1/16A61P13/12A61P29/00
Inventor 颜光涛廖杰邓子辉薛辉
Owner GENERAL HOSPITAL OF PLA
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