30results about How to "Avoid toxic side effects" patented technology

The invention relates to a niacin salvia miltiorrhiza phenolic ester derivative as shown in a formula I or a formula II, a preparation method and application thereof. The preparation method comprises the following steps of: dissolving a tanshinone-type compound in an organic solvent; hydrogenating under the catalysis of a transition metal for a certain time to obtain a salvia miltiorrhiza phenolic compound as a reduced intermediate of the tanshinone-type compound, wherein no separation and purification is needed to be carried out on the intermediate; reacting the intermediate with a niacin anhydride compound to obtain a target product of the niacin salvia miltiorrhiza phenolic ester derivative after separation and purification. In the compound, a niacin-type compound and the salvia miltiorrhiza phenolic compound are connected through ester bonds, the compound is decomposed into the niacin-type compound and the salvia miltiorrhiza phenolic compound through metabolism, and the salvia miltiorrhiza phenolic compound can be spontaneously transformed into the tanshinone-type compound and collaboratively develops bioactivity together with the niacin-type compound. Therefore, the niacin salvia miltiorrhiza phenolic ester compound is a kind of potential mutual prodrug for treating the cardiovascular disease.

The invention provides a microencapsulated multivesicular liposome drug carrier and a preparation method thereof. The method comprises the following steps: with a sucrose solution as an inner water phase, glucose and an L-lysine solution as outer water phases, and a dichloromethane solution dissolved with lipid as an oil phase, carrying out high-speed homogenate emulsification on the inner water phase and the oil phase to form colostrums; adding the outer water phase, carrying out vortex emulsification to form a compound emulsion, carrying out rotary evaporation to remove dichloromethane, so as to obtain a multivesicular liposome suspension; dispersing the multivesicular liposome into a sodium alginate solution, dispersing uniformly, and then dropping into a calcium chloride solution through a high-pressure microcapsule molding device and an injection pump, so as to prepare calcium alginate gel beads embedded with the multivesicular liposome; and finally forming a film from the gel beads and a cationic polymer solution, so as to form a sample, wherein the drug is carried on at least one part in the multivesicular liposome or out of the multivesicular liposome in the microcapsule. According to the microencapsulated multivesicular liposome drug carrier, space allocation of different drugs is ensured; the long-acting release and absorption of the drug are improved; and toxic and side effects caused by simple use of the drug are reduced.

The invention relates to a Lactobacillus with the efficacy of preventing and treating diabetic encephalopathy and a separation method and application thereof. The Lactobacillus is named as a Lactobacillus paracasei LC86 strain, and the preservation unit is China General Microbiological Culture Collection Center, the preservation time is December, 2013, the preservation number is CGMCC 1.12731, andthe address is No. 3, No. 1 Courtyard, Beichenxi Road, Chaoyang District, Beijing City. According to the Lactobacillus, the increase of the content of nitric oxide caused by diabetic encephalopathy can be obviously improved, the antioxidant enzyme activity of brain tissues can be improved, and the learning and memory ability can be improved. The Lactobacillus is applied to medicines for preventing and treating diabetic encephalopathy, has no toxic or side effect, and can be used for treating clinical patients together with other nutrients.

The invention relates to the technical field of medicines on the digestive system, in particular to a nanometer carbon powder and application thereof. The dispersion ratio of the nanometer carbon powder in water is 99.17 percent, and the particle size of more than 95 percent of particles is smaller than or equal to 5 nm. After being applied to the field of medicines and prepared into preparations, the nanometer carbon powder has good effects on gastric ulcer, helicobacter pylori, gastritis, duodenal ulcer, ulcerative colitis, dysentery, enteric infectious diseases and spread of cancer cells and can significantly improve the life quality of people. For treatment of gastric ulcer, the effect is superior to that of sucralfate positive drugs. For inhibition of helicobacter pylori, the effect is superior to that of omeprazole but is inferior to clarithromycin. When the usage amount of the nanometer carbon powder is small than 50 mg / kg, the nanometer carbon powder is nontoxic.

The invention discloses a detergent for eliminating pesticide residues, which is natural, environmental-friendly and free from toxic or side effects. General pesticide residues in vegetables and fruits can be effectively eliminated, and damage of toxic chemicals in agricultural chemicals to human bodies is reduced. The detergent mainly comprises the following components of 3-8% of a dishcloth gourd extract, 2-5% of a honeysuckle flower extract, 0.5-0.8% of brassinolide, 8-15% of sodium alkyl benzene sulphonate, 2-4% of polyaluminium chloride, 6-10% of a surfactant, 1-2% of a preservative, 3-6% of lemon essence and the balance of pure water. The prepared detergent disclosed by the invention has notable advantages that the pesticide residues can be rapidly decomposed and diluted, phosphorus is removed, dirt is removed, the production technology is simple, the cost is low, and the detergent can be widely applied in daily life.

The invention discloses a traditional Chinese medicinal composition for treating rheumatoid arthritis and a preparation method thereof. The traditional Chinese medicinal composition comprises, by weight, the rootbark of Chinese hydrangeavine, celastrus aculeatus, monkshoodvine root-bark, ormosia henryi prain, rubus quinquefoliolatus, roots or stems of diversifolious creepers, allgrass of Chinese alangium, radix alangii, Tonkin pepper herbs, caulis phyllanthi reticulati, pterospermi heterophylli, artemisia sieversiana, Chinese juniper, rhododendron lutescens franch, sphallerocarpus gracilis, hollyhock, tamarisk chinensis, trona, parabarium micranthum, lycopodium clavatum, clerodendrum bungei, cortex acanthopanacis, Chinese fevervine herbs and roots, rhizoma acori graminei, stems of champion bauhinia, philippine flemingia roots, herba lycopodii complanati, gaultheria forrestii diels, campanumoea javanica, Chinese yams, medicated leaven, caulis spatholobi, kadsura pepper stems, cassia twigs, licorice roots, horse bones, eagle bones, rhizoma atractylodis macrocephalae, coix seeds, poria cocos and dried tangerine or orange peels. The traditional Chinese medicinal composition has the effect of promoting blood circulation, removing stasis, dredging collaterals and relieving pain, supports the healthy energy and inhibits toxic and side effects of some drugs, and accordingly, both root causes and symptoms are treated.

The invention discloses the application of curcumin in preparing a medicine for treating the intestinal ischemia reperfusion injury in the technical field of medicine preparation. According to the application of the curcumin in preparing the medicine for treating the intestinal ischemia reperfusion injury, an intestinal ischemia reperfusion injury model is prepared, and curcumin-polyvinylpyrrolidone (PVP) solid dispersions are used for treating the intestinal ischemia reperfusion injury model after being dissolved by normal saline for injection. The therapeutic effect of the curcumin is detected through gross tissue observation, disease model death rate, histopathological changes, serum liver and renal function changes and changes of apoptosis and inflammation-related regulatory factors in tissues. According to results, the intestinal ischemia reperfusion injury can be effectively treated by the curcumin, and a basis is provided for the application of the curcumin in emergency and critical symptoms.

The invention provides a making method of capelin caviar. The caviar consists of the following components of roe, spice fluid, condiments, copper gluconate and a preservative. The caviar is made through the following steps of performing pretreatment: performing salt treatment on fresh roe; performing extraction so as to obtain the spice fluid: taking the following components in parts by weight of purple perilla, fresh ginger, hot peppers, cinnamon bark, cloves, garlic, amomum cardamomum, star aniseeds, fructus tsaoko and Chinese prickly ash, performing decoction for 2-4 times, performing filtration, combining filtrate so as to obtain the spice fluid; performing preparation: taking the roe after the salt treatment and the spice fluid, in parts by weight, performing steaming, performing filtration, performing screening to obtain average-grain roe, taking the average-grain roe, the condiments and the copper gluconate in parts by weight, performing steaming, adding a preservative, and performing uniform mixing so as to obtain the caviar; and performing preservation: placing the caviar in the shade, performing packaging, performing sterilization, performing warehousing, and performing preservation. According to the caviar prepared by the making method disclosed by the invention, high nutrient value of the roe is reserved, the fishy taste and foreign taste are removed, the fresh-keeping time of the caviar is prolonged, the caviar is prevented from being deteriorated in a short time, and the mouth feel and the nutrient value of the caviar are not influenced.

The invention discloses a plaster with a joint injury and acupoint repair effect. The plaster is prepared from, by weight, 35-65 parts of radix dipsaci, 30-57 parts of herba cistanches, 30-55 parts ofroots of sambucus williamsii hance, 20-33 parts of radix aconiti, 15-29 parts of ovateleaf knotweed rhizome, 16-35 parts of flowers of carthamus tinctorius L., 15-27 parts of caulis tinosporae sinensis, 22-38 parts of fried fructus gardeniae, 30-40 parts of frankincense, 6-17 parts of borneol, 10-22 parts of rhzizoma drynariae, 8-25 parts of resina draconis, 15-25 parts of natural copper, 13-24 parts of shaved cinnamon bark and 300-750 parts of a matrix. Through the cooperation of the structures, the plaster solves the problems that by applying bandaging, local sealing, physiotherapy and anti-inflammatory and analgesic drugs, the treatment effects of the methods are poor, the recovery time is long, the drugs are limited to inflammatory prevention and analgesia and lack the functions of promoting local micro-circulation and alleviating local swelling; the plaster quickly relieve pain and swelling of acute soft tissue injuries in the acute phase and promotes function recovery.

The invention discloses a traditional Chinese medicine composition for treating pyesis and a preparation method of the traditional Chinese medicine composition, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials and pharmaceutically common auxiliary materials: astragalus membranaceus, radix angelicae, mangnolia officinalis, liquorice, poria cocos, fructus forsythia, ginseng, angelica sinensis, peony, costus roots, ligusticum wallichii, divaricate saposhnikovia roots, honeysuckle, platycodon grandiflorum, cassia twig and scutellaria baicalensis. The preparation method comprises the following steps: weighing and crushing scutellaria baicalensis for later use; respectively weighing other medicinal materials, adding water to decoct for a plurality of times, and mixing decoction solutions; filtering and concentrating into clear paste; adding ethanol for extraction, drying and crushing ethanol filtrate at a low temperature; and adding broken scutellaria baicalensis and the pharmaceutically common auxiliary materials, and mixing to prepare the medicine. According to the traditional Chinese medicine, the syndrome differentiation treatment of the traditional Chinese medicines and the principle of monarch, minister, assistant and guide, the traditional Chinese medicines are scientifically combined; an effective pharmaceutical composition is provided; and a preparation prepared by a special preparation method has a general therapeutic effect on pyesis caused by pyogenic bacteria, and is good in taste, good in effect and free of toxic or side effect.

The invention provides an externally-applied traditional Chinese medicine composition for treating gout. The externally-applied traditional Chinese medicine composition adopts the compatibility of a sovereign drug, a ministerial drug, an adjuvant drug and a conductant drug to synergistically take effect, wherein the sovereign drug is capable of promoting blood circulation to remove blood stasis, dispelling wind, relieving pains and inducing diuresis to alleviate edema, and has the effects of rapidly decreasing swelling and relieving pains on swellings caused by gout; the ministerial drug is capable of clearing away heat, removing toxicity, purging intense heat, dispersing heart heat, decreasing swelling and relieving pains, is capable of reinforcing the effect of decreasing swelling and relieving pains of the sovereign drug, and is capable of clearing away heat and removing toxicity according to accompanied symptoms of gout; through the compatibility of the sovereign drug and the ministerial drug, the effect of decreasing swelling and relieving pains is achieved, and pains of a patient are rapidly reduced; the adjuvant drug is capable of dispelling wind, eliminating dampness and activating meridians to stop pains, is an assisting drug, and is matched with the sovereign drug and the ministerial drug to reinforce the effects of dispelling wind, decreasing swelling and relieving pains; the drug effect of the guiding drug directly reaches the affected part, and permeates through the anadesma; the compatibility of all the drugs is achieved, the effects of relaxing tendons, activating collaterals, promoting channels, removing dampness, clearing away turbidness, decreasing swelling and relieving pains are jointly achieved, and local swelling pains caused by gout are rapidly relieved.

The invention discloses ointment with effects of removing slough and promoting tissue regeneration, and belongs to the technical field of Chinese herbal medicines and preparations thereof. By the aid of the traditional Chinese medicine ointment, the shortcomings in the prior art can be overcome, and the traditional Chinese ointment is used for treating long-term wound non-healing. The technical scheme includes that the ointment with the effects of removing the slough and promoting the tissue regeneration comprises, by weight, 10-30 parts of borneolum syntheticum, 1-30 parts of hydrargyrum oxydatum crudum, 1-10 parts of margarita, 10-60 parts of boric acid, 0.5-3 parts of lithargite, 10-60 parts of gypsum fibrosum and 0.1-1 part of calomelas. The ointment has the advantages that effects of removing the slough, promoting the tissue regeneration, carrying out astringing and accelerating wound healing can be realized by the ointment which is a traditional Chinese medicine, the ointment can become effective fast and is short in cure time, accordingly, suffering can be relieved for patients, and excellent treatment effects can be realized for non-pathogen infectious wound non-healing for different types of causes.

The invention discloses an anti-liver cancer health product containing isoalantolactone. The raw materials include, by weight percentage, 60-80% of isoalantolactone, 5-10% of a herba scutellariae barbatae extract, 5-10% of a fructus polygoni orientalis extract, 5-10% of a prunella vulgaris extract and 5-10% of a euphorbia helioscopia extract. The pioneering technology adopted by the invention usesisoalantolactone as the anti-liver cancer core functional raw material, puts forward the Chinese medicinal composition treating liver cancer, and through reasonable compatibility, the anti-liver cancer Chinese herbal medicine mixed health product is formed. Experimental study on human in vitro liver cancer cells finds that the isoalantolactone composition has good inhibition effect on in vitro tumor cells and good control effect on liver cancer, can avoid excessive toxic and side effects of chemical synthetic drugs on the human body, and also has wide sources, thus having good application prospects.

The invention discloses a food composition for preventing and treating deficiency of kidney yang as well as an application method thereof. The food composition at least comprises maca, kidney bean, Chinese chive seed and okra, the mass proportion sum of maca, kidney bean, Chinese chive seed and okra is 40-60%, and the raw materials are prepared to mixing powder according to a composition formula and then directly eaten, or the prepared mixing powder and an edible accessory are used for making other food forms for eating. The experiment shows that the food composition can obviously improve and recover injury of sexual gland, accessory organ and immunization organ of deficiency of kidney yang model mouse due to hydrocortisone, normal autonomous activities frequency and capability can be recovered for tested mouse, compared with a model control group, the food composition has significant difference, and the food composition has the health care effects for tonifying kidney and invigorating yang, and replenishing qi and enriching blood, and can be used for treating deficiency of kidney yang by long-term eating.

A double-view-window gradually-progressing lighting-face increasing and reducing alternating correction eye protecting device mainly comprises a light shielding device, view-windows, a view-window switching device, a circulation lighting-face motion changing mechanism and an operation system. The double-view-window gradually-progressing lighting-face increasing and reducing alternating correction eye protecting device is newly designed for overcoming the defects of myopia treatment conducted through operations, medicine and some focus-changing light-emitting instruments and health-care measures and is especially used for treating visual impairment of human beings and caring eyesight of human beings. The eye protecting device has the advantages that a pure physical method is used for treating and caring myopia, especially pseudomyopia and asthenopia, so that toxic side effects generated by medicine treatment, risks caused by operation treatment and light pollution unfavorable factors generated, on eyes, by some products which are used for treating eyes are avoided. Consequently, the device can be used for treating and caring people safely and reliably.

The present invention relates to an anticancer dietary medicine composition and its preparation method. Said composition mainly contains bamboo leaf, fresh ginger, puccoon, peppermint and fruit juice, and its preparation method includes the following steps: soaking bamboo leaf and puccon in white liquor, soaking fresh ginger and peppermint in water, taking out their suppernatant fluids, blending them with fruit juice so as to obtain the invented drinking material product. For patient with carcinomatosis, its usage and dosage are as follows: once 30-40 ml orally, 3-4 times daily, and for normal person it can be used as health-care beverage for preventing cancer, once 20 ml, can be taken before sleep. It can be used for curing various cancers, its cure rate can be up to 36%, and its effective rate can be up to above 97%.

The invention provides a traditional Chinese medicine composition for treating bone injury diseases and a making method of the traditional Chinese medicine composition and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition for treating bone injury diseases is made of dactylicapnos roots, psammosilene tunicoides, rheum officinale, anisodusacutangulus, kusnezoff monkshood roots, radix angelicae tuhuo, asarum, nux vomica, alangium platanifolium, white mustard seeds, cissus hexangularis, shortstalk monkshood roots, sanguis draxonis, lithargite, pseudo-ginseng, musk and plant oil according to a ratio. Due to matching of dactylicapnos roots, psammosilene tunicoides, rheum officinale, anisodus acutangulus, kusnezoff monkshood roots, radix angelicae tuhuo, asarum, nux vomica, alangium platanifolium, white mustard seeds, cissus hexangularis, shortstalk monkshood roots, sanguis draxonis, lithargite, pseudo-ginseng, musk and plant oil asmaster medicines, assistant medicines and auxiliary medicines, the traditional Chinese medicine composition has effects on pain diseases such as arthritis, hyperostosis, cervical spondylosis, bone fracture, intervertebral disc protrusion, gout and rheumatism.

The invention relates to the technical field of nano drug carriers, and specifically discloses a preparation method and application of tussah silk fibroin nanoparticles. Turbid liquid, ultrasonic, centrifugal separation, freeze-drying and other operations. The present invention uses natural tussah silkworm cocoons with excellent biocompatibility as raw materials to ensure the biosafety performance of nanocarriers, and the whole preparation method is simple and quick, and tussah silk nano-particles containing RGD peptide natural targeting ligands are prepared to avoid It avoids the severe environment and the toxic and side effects caused by the residue of organic solvents in the modification process of foreign ligands, and at the same time has a good function of targeting macrophages, the particle size distribution is relatively uniform, and it has high drug loading and encapsulation. It has a good application potential in the treatment of ulcerative colitis.

The invention belongs to the field of traditional Chinese medicines and particularly relates to an oral traditional Chinese medicine composition for treating depressive disorder as well as a preparation and preparation method thereof. The oral traditional Chinese medicine composition is prepared from pharmaceutically acceptable auxiliaries, radix bupleuri, angelica, radix paeoniae alba, ramulus cinnamomi, crinum asiaticum and pleurotus citrinopileatus, wherein radix bupleuri, angelica, radix paeoniae alba, ramulus cinnamomi and pleurotus citrinopileatus are extracted by virtue of a water extraction alcohol precipitation method, and crinum asiaticum is a volatile oil component which has a relative density lower than 1.0 and is extracted by virtue of a vapor distillation method. The dose form of the oral traditional Chinese medicine composition is oral liquid. The oral traditional Chinese medicine composition has good treatment effects on depressive disorder and further has safety.

The invention discloses an antidepressant health-care product containing rice husk flavone. The antidepressant health-care product is prepared from the following raw materials in percentage by weight: 50 to 70 percent of the rice husk flavone, 5 to 10 percent of a rhizoma cyperi extract, 5 to 10 percent of a rhizoma atractylodis macrocephalae extract, 5 to 10 percent of a poria extract, 5 to 10 percent of a radix notoginseng extract and 5 to 10 percent of a medicated leaven extract. A groundbreaking technology disclosed by the invention is that the rice husk flavone is used as an antidepressant core functional material; a provided traditional Chinese medicinal composition for treating depression is reasonable in matching; a flavone and Chinese herbal medicine mixed health-care product with an antidepressant effect is formed. According to the antidepressant health-care product disclosed by the invention, found by experimental research on an in vitro depression cell model, the composition containing the rice husk flavone has a better protecting effect on cells and obvious effects on prevention and treatment of the depression; toxic and / or side effects caused by excessive chemical synthetic drugs can be avoided; in addition, the antidepressant health-care product is low in price and wide in sources, so the rice husk flavone composition attracts a wide spread attention.

Provided is a hybrid nanoparticle, including an aggregate assembled from a plurality of polymeric molecules, and a plurality of boron-doped graphene quantum dots localized in the aggregate. The polymeric molecule is preferably a pH-responsive dendrimer; the polymeric molecule and the boron-doped graphene quantum dot may be separately associated with different drugs; and hybrid nanoparticle may further include a targeting molecule, such as a rabies virus glycoprotein. Also provided is a method of controlling disassembly of a hybrid nanoparticle, including applying a high-frequency magnetic field to the hybrid nanoparticle to induce disassembly thereof. Also provided is an application of the hybrid nanoparticle for preparing a tumor-penetrating drug carrier.

The invention relates to a traditional Chinese medicinal composition for treating gastrointestinal cancer. The composition is prepared through clinic test repeated verification, and accords with the theory of traditional Chinese medicine science. The composition adopts Raphanus sativus L, toad skin, Radix araliae armatae, persimmon frost, Kalimeris indica and Glabrous Sarcandra Herb as main medicines to realize heat clearing, detoxifying, cancer preventing and evil expelling, adopts cherry leaf, all-grass of Matsumura Leafflower, leaf of Jobstears, orange peel, dry moss and Fiveleaf Gynostemma Herb as auxiliary medicines to reinforce heat clearing, detoxifying and cancer preventing efficacies, adopts asparagus, Lobelia sessilifolia Lamb., Garcinia mangostana L., orange peel and mulberry to tonify qi, nourish stomach, warm meridian and relieve pains, and adopts apple, grape, banana, jujube, Oberonia iridifolia Lindl, Root of Delavay Schefflera, twoleaf beadruby herb and serrate gtorybower flower to nourish spleen, harmonize stomach, invigorate spleen, tonify lung and moisten intestine. The composition starts with qi tonifying, stomach nourishing and gastrointestinal mucosa damage reducing health efficacies and health, selects traditional Chinese medicines to directly kill cancer cells and block generation of newborn blood vessels to make the cancer cells cannot obtain sufficient nutrition supply, and has unique curative effects on various stomach cancer patients.