Nanometer hemostatic material product and preparation method thereof

A hemostatic material and nanotechnology, applied in textiles and papermaking, medical science, fiber processing, etc., can solve the problems of unsatisfactory production or use process, tissue damage, slow hemostasis, etc., to promote normal growth, promote repair, promote effect of growth

Inactive Publication Date: 2012-09-19
中国人民解放军第四五四医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the new hemostatic materials used for war wounds, such as chitosan, fibrin, collagen, zeolite, etc., can effectively stop bl

Method used

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  • Nanometer hemostatic material product and preparation method thereof
  • Nanometer hemostatic material product and preparation method thereof
  • Nanometer hemostatic material product and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: Prepare a nanofiber membrane with a blood carbon content of 5 wt%, and the corresponding proportions of the polymer solution to be prepared: blood carbon content is 0.25 wt%, polylactic acid is 4.75%, and organic solvent is 95 wt%. The specific operation is: weigh 0.627g polylactic acid PLLA and 0.033g blood residue carbon with a balance, dissolve them in 7ml chloroform and 3.5ml acetone, and seal the bottle mouth to prevent solvent volatilization. Stir on a magnetic stirrer for 5 hours until completely dissolved to obtain an electrospinning polymer solution. Electrospinning was performed on the obtained solution, the applied voltage was 20KV, the receiving distance was 12cm, the spinning speed was 0.7ml / h, and the diameter of the spinneret was 0.8mm. The diameter of the obtained nanofiber is between 300nm and 900nm, and the filaments are relatively uniform.

Embodiment 2

[0023] Example 2: Preparation of a nanofiber membrane with a blood carbon content of 10 wt%, corresponding to the proportion of the polymer solution to be prepared: blood carbon content is 0.5 wt%, polylactic acid is 4.5%, and organic solvent is 95 wt%. The specific operation is as follows: weigh 0.594g polylactic acid PLLA and 0.066g blood residue charcoal with a balance, dissolve them in 7ml chloroform and 3.5ml acetone, and seal the bottle mouth to prevent solvent volatilization. Stir on a magnetic stirrer for 5 hours until complete dissolution. That is, the electrospinning polymer solution is obtained. Electrospinning was performed on the obtained solution, the applied voltage was 20KV, the receiving distance was 12cm, the spinning speed was 0.7ml / h, and the diameter of the spinneret was 0.8mm. The diameter of the obtained nanofiber is between 350nm and 1000nm, and the filament formation is relatively uniform.

Embodiment 3

[0024]Example 3: Prepare a nanofiber membrane with a blood carbon content of 15 wt%, and the corresponding ratio of the polymer solution to be prepared: blood carbon is 0.75 wt%, polylactic acid is 4.25 wt%, and organic solvent is 95 wt% . The specific operation is: weigh 0.561g polylactic acid PLLA and 0.099g blood residue carbon with a balance, dissolve them in 7ml chloroform and 3.5ml acetone, and seal the bottle mouth to prevent solvent volatilization. Stir on a magnetic stirrer for 5 hours until complete dissolution. That is, the electrospinning polymer solution is obtained. Electrospinning was performed on the obtained solution, the applied voltage was 20KV, the receiving distance was 12cm, the spinning speed was 0.7ml / h, and the diameter of the spinneret was 0.8mm. The diameter of the obtained nanofiber is between 500nm and 1100nm, which is increased compared with the above two implementations.

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Abstract

The invention relates to a nanometer hemostatic material product. According to the invention, a carbonized hair loaded high polymer composite nanometer fiber membrane is formed by taking carbonized hair as an adding drug, taking a biodegradable high polymer material as a nanometer fiber membrane matrix and adopting an electrostatic spinning method, wherein the content of the carbonized hair in the nanometer fiber membrane is 5-20wt%. The carbonized hair loaded high polymer composite nanometer fiber membrane can be combined with medically acceptable carriers comprising gauzes, bandages, medicinal cottons and medical dressings so as to manufacture products of hemostatic parcels, hemostatic bandages and hemostatic dressings.

Description

technical field [0001] The invention relates to a medical hemostatic product, in particular to a nanometer hemostatic material product and a preparation method thereof. Background technique [0002] In conventional wars, massive blood loss is an important cause of disability and even death of the wounded. For example, in the Vietnam War, the number of people who died of hemorrhage caused by serious injuries accounted for more than half of the total number of deaths. Therefore, timely and effective hemostasis is the key to saving the life of the wounded, stabilizing the injury, and creating conditions for follow-up treatment. In recent years, countries all over the world have attached great importance to the research on hemostasis measures for war wounds, especially the research on new medical hemostatic products suitable for field first aid has become a new hot spot. At present, the new hemostatic materials used for war wounds, such as chitosan, fibrin, collagen, zeolite, e...

Claims

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Application Information

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IPC IPC(8): A61L15/44A61L15/26D01D5/00
Inventor 朱元元邱彦赵伯诚周永陆瑜周斌陈志龙陈娜刘志强
Owner 中国人民解放军第四五四医院
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