Simethicone composition

A technology of simethicone and a composition, applied in the field of simethicone composition, can solve the problems of inability to solve nausea, low defoaming ability and the like, and achieves the effects of convenient operation, improved tolerance, and reduced degree of nausea

Active Publication Date: 2012-09-26
CHONGQING SKYFORBIO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The oral solid preparation of the invention is stable in quality, controllable, safe and effective, but the solid preparation cannot solve the discomfort symptoms such as nausea in a small number of patients, and simethicone and loperamide hydrochloride are prepared by common techniques, and loperamide hydrochloride and The antifoaming ability of simethicone in oral solid preparations with simethicone as the main component is lower than that of simethicone alone

Method used

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  • Simethicone composition
  • Simethicone composition
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Simethicone Glucose Granules

[0022] prescription

[0023] Simethicone 80g

[0024] Glucose 1120g

[0025] Make 1000 bags

[0026] craft

[0027] Take simethicone and heat it to about 90°C, slowly add it into glucose as a binder and stir at high speed to granulate, pass through an 80-mesh sieve, mix evenly, and pack into bags, 1.2g / bag.

[0028] Instructions

[0029] Take a pack of simethicone granules, add about 40ml of water to dissolve and shake well, set aside.

[0030] clinical information

[0031] From December 2010 to March 2011, a hospital in Chongqing admitted and treated 80 patients who underwent gastroscopy, all of whom excluded stomach remnants and liver cirrhosis. The patients were randomly divided into two groups: 22 males in the control group and 22 females. 18 cases; aged 22 to 68 years, with an average of 40.8 years. The research group consisted of 24 males and 16 females; aged 23 to 69 years, with an average of 41.2 years. The 80 patients wer...

Embodiment 2

[0040] prescription

[0041] Simethicone 40g

[0042] Glucose 1120g

[0043] Make 1000 bags

[0044] craft

[0045] Take simethicone and heat it to about 90°C, slowly add it to glucose as a binder and stir at high speed to granulate, pass through an 80-mesh sieve, mix evenly, and pack into bags, 1.16g / bag.

Embodiment 3

[0047] prescription

[0048]

[0049] craft

[0050] Mix glucose and microcrystalline cellulose, add simethicone at about 90°C as a binder to granulate, then add micronized silica gel, mix evenly, and press into tablets, 1.1g / tablet.

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Abstract

The invention relates to a simethicone composition, in particular to a simethicone solid composition. The composition is prepared from simethicone, glucose, and pharmaceutically acceptable adjuvants through preparation technology. The oral solid preparation has the advantages of stable and controllable quality, safety and effectiveness.

Description

technical field [0001] The present invention relates to a kind of antifoaming agent for gastrointestinal exhaust, in particular to a kind of simethicone composition. Background technique [0002] Gastroscopy is an effective examination method for diagnosing upper gastrointestinal diseases and treating some upper gastrointestinal diseases. However, foamy mucus adheres to the surface of the esophagus and gastric mucosa, resulting in unclear vision, affecting endoscopic observation, and even causing various illusions , is also the main cause of missed diagnosis and misdiagnosis. During the gastroscopy process, some people will feel flatulence and nausea due to the air entering the stomach with the tube, which will bring discomfort to the patient, thus increasing the difficulty of the doctor in performing the gastroscopy operation. [0003] Simethicone is a mixture of simethicone (or dimethyl polysiloxane) and silicon dioxide. It is often used as an exhaust defoamer in gastrosc...

Claims

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Application Information

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IPC IPC(8): A61K31/695A61K31/7004A61K47/24A61P1/00A61P1/08
Inventor 王国华
Owner CHONGQING SKYFORBIO
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