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Bismuth citrate synthesizing method

A bismuth citrate and synthesis method technology, applied in the direction of carboxylate preparation, etc., can solve the problems of environmental hazards, increased labor load, unfavorable large-scale production, etc., and achieve the effect of complete reaction, mild process conditions, and less impurities

Inactive Publication Date: 2012-09-26
SHANGHAI MODERN HASEN SHANGQIU PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, bismuth oxide and citric acid need to be fully mixed evenly in the early stage of the reaction, which increases the labor load and is not conducive to large-scale production.
In addition, a high-pressure reaction is required during the reaction process, which poses a serious safety hazard, and the final filtrate is not treated accordingly, causing harm to the environment

Method used

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  • Bismuth citrate synthesizing method

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Effect test

Embodiment 1

[0014] A kind of bismuth citrate synthesis method, it comprises the following steps:

[0015] Dissolve 672.5g of citric acid completely in 324g of water at a temperature of 45°C, then add 466g of bismuth oxide, heat up to 80°C after mixing, and react at normal pressure for 20 hours (tested with ammonia water with a mass concentration of 25-28%, no precipitation ), the reaction product was filtered, washed with water, and dried to obtain 789.6 g of white powdery solid, namely bismuth citrate, with a yield of 99.2%.

Embodiment 2

[0017] Dissolve 730.1g of citric acid completely in 342g of water at a temperature of 46°C, then add 466g of bismuth oxide, heat up to 83°C after mixing, and react at normal pressure for 22 hours (tested with ammonia water with a mass concentration of 25-28%, no precipitation ), the reaction product was filtered, washed with water, and dried to obtain 791.2 g of white powdery solid, namely bismuth citrate, with a yield of 99.4%.

Embodiment 3

[0019] Dissolve 768.6g of citric acid completely in 360g of water at 48°C, then add 466g of bismuth oxide, mix well, heat up to 85°C, and react at normal pressure for 24 hours (tested with ammonia water with a mass concentration of 25-28%, no precipitation ), the reaction product was filtered, washed with water, and dried to obtain 790.4 g of white powdery solid, namely bismuth citrate, with a yield of 99.3%.

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Abstract

The invention belongs to the technical field of complexe synthesis, and specifically relates to a bismuth citrate synthesizing method. The bismuth citrate synthesizing method comprises the following steps: dissolving a citric acid in water at a temperature of 45-48 DEG C; then adding bismuth oxide into the obtained mixture, and uniformly mixing the obtained product; carrying out atmospheric reaction on the obtained product for 20-24 hours at a temperature of 80-85 DEG C; and filtering, washing and drying the obtained reaction product so as to obtain white powdered solids, namely, bismuth citrate, wherein the molar ratio of the bismuth oxide to the citric acid to the water is 1:(3.5-4):(18-20). The method is performed under atmospheric pressure and low temperature conditions, the reaction conditions are mild, meanwhile, the product yield is high, and the quality of products is good.

Description

technical field [0001] The invention belongs to the technical field of coordination compound synthesis, and in particular relates to a synthesis method of bismuth citrate. Background technique [0002] Bismuth citrate, molecular formula BiC 6 h 5 o 7 , with a molecular weight of 398 and a chemical structural formula as shown below. It is a broad-spectrum fungicide commonly used in medicine and has the characteristics of low toxicity. It has certain biological activity and participates in the synthesis of many drugs for treating intestinal diseases. [0003] [0004] There are many research reports on the synthesis methods of bismuth citrate, mainly including: 1) Traditional process method - semi-quantitative ammonia solution method. The method it adopts is mainly prepared by adding the basic nitrate of bismuth to citric acid. It is mixed with nitrate ions in the product, and the product is highly toxic; and there is the production of nitric acid as a by-product, whic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C59/265C07C51/41
Inventor 邵冠儒江正祥王德俊宋振峰刁文瑞
Owner SHANGHAI MODERN HASEN SHANGQIU PHARMA
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