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Enzymatic wound debriding compositions with enhanced enzymatic activity

A technology of composition and enzymatic activity, which can be used in pharmaceutical combinations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., and can solve problems such as blocking proteolytic enzymes

Active Publication Date: 2012-10-03
SMITH & NEPHEW ORTHOPAEDICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, enzymatic wound debridement compositions based on hydrophobic matrices are usually immiscible in the aqueous environment of the wound bed, thus, the access of proteolytic enzymes to the wound bed is usually hindered

Method used

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  • Enzymatic wound debriding compositions with enhanced enzymatic activity
  • Enzymatic wound debriding compositions with enhanced enzymatic activity
  • Enzymatic wound debriding compositions with enhanced enzymatic activity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0139] The following examples serve to demonstrate certain non-limiting aspects of the invention. It should be appreciated by those of skill in the art that the techniques disclosed in the examples which follow represent techniques discovered by the applicant to function adequately in the practice of the invention. However, in light of the present invention, those skilled in the art will understand that many changes can be made in the disclosed embodiments without departing from the spirit and scope of the invention and still obtain the same or similar results.

example 1

[0140] Example 1: Dispersion of Collagenase / PEG 400 in Vaseline

[0141] The dispersions in Table 1 were prepared from different concentrations of polyethylene glycol 400 (PEG-400) dispersed in petrolatum.

[0142] Table 1

[0143]

[0144] *PEG-1450 was added to PEG-400 to form a semi-solid, yielding about 96% and 100% of total PEG, respectively.

[0145] The enzymatic debridement activity of each dispersion was determined by the above-mentioned in vitro artificial eschar model, and the results were obtained in figure 1 drawn in. as from figure 1 From the results it can be seen that the optimal amount of PEG-400 is about 20% w / w PET-400 based on the 24 hour curve.

example 2

[0146] Example 2: Dispersion of Collagenase / PEG 600 in Vaseline

[0147] The dispersions in Table 2 were prepared from different concentrations of polyethylene glycol 600 (PEG-600) dispersed in petrolatum.

[0148] Table 2

[0149]

[0150] The enzymatic debridement activity of each dispersion was determined by the in vitro artificial eschar model described above. result in figure 2 drawn in. as from figure 2 From the results it can be seen that the optimal amount of PEG-600 is about 30% w / w PEG-600 based on the 24 hour curve.

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Abstract

The present invention is directed to topical enzymatic wound debriding compositions with enhanced enzymatic activity. These compositions comprise a dispersed phase comprising at least one proteolytic enzyme and at least one hydrophilic polyol; and a continuous phase comprising a hydrophobic base.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Application No. 61 / 267,730, filed December 8, 2009, the contents of which are incorporated by reference. technical field [0003] The present invention relates generally to topical enzymatic wound debridement compositions and methods for treating wounds in need of debridement. Background technique [0004] Wound healing is a complex process that is often further complicated by the presence of nonviable necrotic tissue in the wound area. Debridement is the process of removing nonviable tissue from a wound in order to prevent or reduce infection and facilitate healing. Topical compositions containing proteolytic enzymes such as trypsin, papain, bromelain, subtilisin, sutilanase and collagenase have been used for enzymatic wound debridement. Typically, the standard of care is to apply the composition to wounds requiring debridement once a day (every 24 hours), or mor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/48A61L15/38A61L26/00
CPCA61L15/34A61K38/4826A61K38/4886A61L2300/254A61L15/26A61L15/38A61L15/44A61K38/4873A61L26/0019A61K38/488A61L26/0066C12Y304/24027A61P17/02A61P43/00C08L71/02A61K9/10A61K38/48A61K47/30A61K47/44C12N9/00A61K9/06A61K47/10
Inventor 磊·石A·乔瓦诺维奇D·奥斯特
Owner SMITH & NEPHEW ORTHOPAEDICS
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