Spraying and coating combined complex tissue organ manufacturing system

Abstract

The invention discloses a spraying and coating combined complex tissue organ manufacturing system which belongs to the technical field of tissue engineering. The spraying and coating combined complex tissue organ manufacturing system comprises a multi-nozzle spraying unit, a three-dimensional movement unit, a forming table, a forming table gesture adjustment device, a temperature control device, a sterilization device, a shell, a bracket and a control unit, wherein the multi-nozzle spraying unit is arranged on the three-dimensional movement unit; the forming table is arranged on the top of the forming table gesture adjustment unit; under the control of the control unit, the nozzles are capable of moving according to set paths and coating according to set orders; and relative angles between central shafts of the nozzles and the surface of the forming table can be changed, so that the manufacturing of complicated curved surfaces is convenient. Through the invention, various subsequent treating processes are finished while a plurality of cells and bracket materials are arrayed to corresponding positions at one time according to computer instructions; and the formed three-dimensional structures can be directly connected with corresponding circulating systems in the body so as to rapidly realize various physiological functions of complex tissue organs.

Description

technical field [0001] The invention belongs to the field of organ manufacturing, in particular to a complex tissue and organ manufacturing system combining spraying and spraying. Background technique [0002] The rapid prototyping technology that came out in the late 1980s, as an important member of advanced manufacturing technology, gradually entered the field of stent forming. The new additive process created by it provided a new idea for solving the problems existing in the traditional stent forming technology. . Massachusetts Institute of Technology in the United States, Carnegie Mellon University, University of Michigan, National University of Singapore and Tsinghua University in China are all engaged in research work in this area. Among them, some researchers use the existing rapid prototyping process equipment and scaffold materials to form directly, such as the research group of D. Hutmacher of the National University of Singapore, the research group of M.J. Cima o...

AI Technical Summary

Problems solved by technology

[0012] ①The forming table can only rely on the three-dimensional motion device to move, and the position parameters are controlled by the mutually perpendicular X-axis and Y-axis when processing circular section and ring section materials, and the accuracy needs to be improved

[0013] ②The fixed nozzles are all screw extruded and cannot be replaced. There are structural disadvantages in cell assembly or printing processing, and it is impossible to accurately control the number of cells printed, the thickness of the cell layer, and the exact position

[0014] ③There is only one nozzle for each nozzle of the injection device, which has great limitations when performing multi-cell and multi-directional forming

[0015] ④ It cannot meet the requirements of forming micron-scale high-viscosity gels, slurries or solutions, and spraying nano-scale low-viscosity single-layer cells, cell growth factors, cross-linking agents or polymer solution layers, thus making complex tissue and organ manufacturing difficult. The forming process and the post-processing process cannot be carried out synchronously

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