Composite type complex organ precursor three-dimensional controlled forming system with multiple sprayers

Abstract

A composite type complex organ precursor three-dimensional controlled forming system with multiple sprayers belongs to the technical field of tissue engineering and mainly comprises a box, a top support, a free jetting device, a fixed jetting device with multiple sprayers, a forming table, a three-dimensional motion mechanism, a refrigerating device and a control system. The free jetting device and the fixed jetting device with the multiple sprayers are combined to form a composite device with the multiple sprayers. As the fixed jetting device with the multiple sprayers moves vertically and the forming table rotates, the sprayers can relatively move and work independently or cooperatively, and a multidirectional and multi-angular fast accumulation and jetting forming process under the cooperation effect of the multiple sprayers is realized.

Description

technical field [0001] The invention belongs to the field of tissue engineering, and in particular relates to the design of a composite multi-nozzle complex organ precursor three-dimensional controlled forming system. Background technique [0002] Tissue engineering is a popular interdisciplinary subject at present. Its three major elements are cells, biomaterial scaffolds and growth factors. [0003] The rapid prototyping technology that came out in the late 1980s, as an important member of advanced manufacturing technology, gradually entered the field of stent forming. The new additive process created by it provided a new idea for solving the problems existing in the traditional stent forming technology. . Massachusetts Institute of Technology in the United States, Carnegie Mellon University, University of Michigan, National University of Singapore and Tsinghua University in China are all engaged in research work in this area. Among them, some researchers use the existi...

AI Technical Summary

Problems solved by technology

[0013] ①The fixed spraying device can only use one nozzle for processing at the same time, and the molding efficiency is low. When switching the nozzle, the three-dimensional motion device is required to be re-centered, and the connection error of the nozzle's injection effect is relatively large;

[0014] ②The number of nozzles on the nozzle bracket is large, but only one nozzle works at the same time, and the rest of the nozzles cannot move or work together, and the relative positions of the nozzles are fixed, which is inefficient;

[0015] ③The forming table can only rely on the three-dimensional motion device to move, and the position parameters are controlled by the mutually perpendicular X-axis and Y-axis when processing circular section and ring section materials, and the accuracy needs to be improved;

[0016] ④The fixed nozzles are all screw extrusion type and cannot be replaced. There are structural disadvantages in the cell printing process, and the number and precise position of the cell printing cannot be controlled;

[0017] ⑤ There is only one nozzle for each nozzle of the injection device, which has great limitations when performing multi-cell and multi-directional forming

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