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Asiatate granules and preparation method thereof

A technology of oxalate and granules, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, powder delivery, etc. It can solve the problems of unsatisfactory drug efficacy and low bioavailability, and achieve broad market prospects and practical value , good quality stability and stable disintegration index

Inactive Publication Date: 2015-06-24
SHANGHAI INST OF PHARMA IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention is to overcome the defects that the existing asiatic acid and its salt granules have unsatisfactory drug efficacy and extremely low bioavailability, and provide a kind of asiatic acid salt with good bioavailability Granules and their preparation method

Method used

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  • Asiatate granules and preparation method thereof
  • Asiatate granules and preparation method thereof
  • Asiatate granules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024]

[0025]

[0026] Preparation method: Mix all raw materials evenly, granulate and dry.

[0027] After making a preparation suitable for intravenous administration with asiatic acid tromethamine salt and physiological saline, intravenous administration (rat tail vein injection method, see "Journal of Southern Medical University" 2009 06 issue) at the same time according to the prescription The bioavailability of asiatic acid tromethamine salt in the obtained granules was determined after the first administration to SD rats was 23.6%.

Embodiment 2

[0029]

[0030] Preparation method: Mix all raw materials evenly, granulate and dry.

[0031] The bioavailability of the asiatic acid tromethamine salt in the obtained granules is 20.8%, as determined by administering the same single dose to SD rats simultaneously with the intravenous administration of the asiatic acid tromethamine salt.

Embodiment 3

[0033]

[0034] Preparation method: Mix all raw materials evenly, granulate and dry.

[0035] The bioavailability of the asiatic acid tromethamine salt in the obtained granules is 17.4% as determined by administering the same single dose to SD rats simultaneously with the intravenous administration of the asiatic acid tromethamine salt.

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Abstract

The invention discloses asiatate granules and a preparation method thereof. The asiatate granules comprise 1-40% of trometamol asiatate, 25-60% of filler, 1-10% of binder and 0-40% of disintegrating agent in mass percentages of the total amount of the asiatate granules. The preparation method comprises the following steps: according to a formulation, uniformly mixing the components; granulating; and drying. The asiatate granules have good bioavailability.

Description

technical field [0001] The invention relates to a centella asiatica granule and a preparation method thereof. Background technique [0002] It is reported in the prior art that asiatic acid and its salts can prevent and treat fibrosis diseases of some internal organs, but the drug efficacy of the related granules is not ideal, and the bioavailability is extremely low. In order to maximize the effective utilization of the drug, this The status quo needs to be resolved urgently. Contents of the invention [0003] The technical problem to be solved by the present invention is to overcome the defects that the existing asiatic acid and its salt granules have unsatisfactory drug efficacy and extremely low bioavailability, and provide a kind of asiatic acid salt with good bioavailability Granules and methods for their preparation. [0004] The formula of the asiatic acid salt granule of the present invention contains 1%-40% asiatic acid tromethamine salt, 25%-60% filler, 1%-10%...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/56A61K9/14
Inventor 刘英刘全海陆伟根刘珉宇黄晓玲张瑱肖璘陈仁海潘绵立陈志祥李燕
Owner SHANGHAI INST OF PHARMA IND CO LTD