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Xiao Jin dispensible tablet and preparation method thereof

A technology of dispersible tablets and medicinal materials, which is applied in the field of Xiaojin dispersible tablets and its preparation, which can solve the problems of slow drug dissolution, difficulty in preparation, and influence on drug efficacy, and achieve the effects of fast absorption by the human body, simple preparation, and convenient administration

Inactive Publication Date: 2012-11-07
JIANGXI HERBFINE HI TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Xiaojin Pills is a pasty pill made by crushing the original medicinal materials and adding starch and starch paste. The disintegration and drug dissolution are slow, and it needs to be broken before taking. The difference in the degree of breaking will lead to the difference in the dissolution rate of the drug and the difference in drug release in the body. drug effect
Moreover, the prescription contains a large amount of resinous medicinal materials (frankincense, myrrh, liquidambar), which will be bonded due to the softening of the resin during the pulverization process, resulting in difficulty in preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The weight ratio of each component of Xiaojin Dispersible Tablets is: 30 parts of Xiaojin Wan original medicinal material powder and extract, 0.1 part of clathrate material, 0.5 part of adsorbent, 40 parts of filler, and 2.5 parts of disintegrating agent; It is made of the following traditional Chinese medicine raw materials in the following weight ratio: 28 parts of artificial musk, 145 parts of wood turtle, 145 parts of aconitum, 145 parts of maple gum, 70 parts of frankincense, 70 parts of myrrh, 145 parts of Wulingzhi, and 145 parts of wine angelica 70 parts, 145 parts of Dilong, and 10 parts of Xiangmo.

[0020] The adsorbent is microcrystalline cellulose; the disintegrant is croscarmellose sodium (CCMC-Na); the filler is calcium hydrogen phosphate.

[0021] The preparation method comprises the following steps:

[0022] (1) Preparation of inclusion materials: Dissolve artificial musk in an appropriate amount of ethanol, and slowly add it dropwise to a saturated aq...

Embodiment 2

[0027] The weight ratio of each component of Xiaojin Dispersible Tablets is: 40 parts of Xiaojin Wan original medicinal material powder and extract, 0.2 part of clathrate material, 0.8 part of adsorbent, 45 parts of filler, 6 parts of disintegrating agent, 0.5 part of lubricant; The powder and extract are made of the following traditional Chinese medicine raw materials in the following weight ratio: 30 parts of artificial musk, 150 parts of wood turtle seed, 150 parts of aconitum aconitum, 150 parts of sweetgum balm, 75 parts of frankincense, 75 parts of myrrh, Wulingzhi 150 parts, 75 parts of wine angelica, 150 parts of earthworm, 12 parts of fragrant ink.

[0028] Among them, the adsorbent is high quality microcrystalline cellulose, starch, calcium carbonate, diatomaceous earth and micropowder silica gel; PVPP), pregelatinized starch; fillers are microcrystalline cellulose, starch, lactose, calcium sulfate, calcium hydrogen phosphate of equal quality; lubricants are magnesiu...

Embodiment 3

[0035] The weight ratio of each component of Xiaojin Dispersible Tablets is: 50 parts of Xiaojin Wan original medicinal material powder and extract, 0.3 part of clathrate material, 1 part of adsorbent, 50 parts of filler, 10 parts of disintegrating agent, 1 part of lubricant; The powder and extract are made of the following traditional Chinese medicine raw materials in the following weight ratio: 32 parts of artificial musk, 155 parts of wood turtle, 155 parts of aconitum, 155 parts of sweetgum, 80 parts of frankincense, 80 parts of myrrh, Wulingzhi 155 parts, 80 parts of wine angelica, 155 parts of earthworm, 14 parts of fragrant ink.

[0036] The adsorbent is micropowder silica gel; the disintegrant is cross-linked polyvinylpyrrolidone (PVPP); the filler is lactose; the lubricant is talcum powder.

[0037] The preparation method comprises the following steps:

[0038] (1) Preparation of clathrate material: Dissolve artificial musk in an appropriate amount of ethanol, and sl...

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PUM

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Abstract

The invention relates to a Xiao Jin dispensible tablet and a preparation method thereof. The preparation method is as follows: muskone, semen momordicae, prepared kusnezoff monkshood root, resina liquidamberis, frankincense, myrrh, trogopterus dung, alcohol processed radix angelica sinensis, lumbricus and fragrance ink are taken as raw materials to prepare raw medicine material fine powder and extract fine powder, and a proper amount of auxiliary material is added, so that a Xiao Jin dispensible tablet capable of being disintegrated within three minutes fully and achieveing a uniform dispensible state is prepared. The Xiao Jin dispensible tablet has efficacies of removing stasis and decreasing swellinging, is used for curing crewels, goiter and tumor, lump in breast which are caused by nitrogen stagnation and have the symptoms that part or a plurality of parts of skin or part or a plurality of parts of masses under the skin can be pushed to move, or the bone or bone joints are swelled, are not changed in skin color, has sclerema and is painful; and the Xiao Jin dispensible tablet has the characteristics that the Xiao Jin dispensible tablet can be disintegrated and dispersed uniformly, is easier to accept and take by patients, and is more convenient to carry and use.

Description

technical field [0001] The invention relates to a Xiaojin dispersible tablet and a preparation method thereof, belonging to the field of traditional Chinese medicine preparations. Background technique [0002] Xiaojin Wan is recorded in the "Chinese Pharmacopoeia" 2010 edition. It is composed of 10 original Chinese medicines such as artificial musk, wood turtle, aconitum, sweetgum, frankincense, myrrh, wulingzhi, wine angelica, earthworm, and fragrant ink. It is prepared and has the effects of dispelling stagnation, reducing swelling, removing blood stasis and relieving pain. It is used for scrofula, goiter, breast rock, and breast addiction caused by phlegm stagnation. Symptoms include one or several lumps on the skin or under the skin, which can be moved when pushed, or swelling of bones and joints, unchanged skin color, and swelling. Hard pain. Clinically, it is mainly used for goiter, benign prostatic hyperplasia, postherpetic neuralgia, acne conglomerate, breast cysti...

Claims

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Application Information

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IPC IPC(8): A61K36/714A61K9/20A61P29/00A61P15/14A61P31/06A61P35/00A61P19/08A61P19/02A61P13/08A61P31/22A61P17/10A61P15/00A61P19/04
Inventor 刘红宁李东勳罗晓健张国松刘文勇饶小勇杨世林简晖雷景邦王琦
Owner JIANGXI HERBFINE HI TECH
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