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High-fat purified feed establishing metabolic syndrome animal model and processing technology

A technology for metabolic syndrome and animal models, which is applied in the field of building medical models, can solve problems such as the destruction of nutritional components, the destruction of effective components, and the destruction of material components, and achieve the effects of nutritional balance, good stability, and good repeatability

Inactive Publication Date: 2012-11-14
JIANGSU MEIDISEN BIOLOGICAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The feed in this case has the following problems: 1. Most of the materials in the formula are not purified substances. Most of the raw materials, such as corn, flour, pork floss, grass powder, fish meal, bran, etc., have strong seasonality, and the regions of origin Complicated, which makes the nutrient content in it uneven, resulting in insufficient feed stability and poor reproducibility
2. The nutritional structure of this kind of feed is not comprehensive, it can only be used for fattening, and it lacks some necessary substances for animals, so it cannot form a stable model disease
3. This kind of formula is difficult to process at low temperature into a pellet feed that meets the hardness and taste of rodents. In other words, some of the effective components will be destroyed by conventional processing (temperature 102-110°C)
[0004] To sum up, currently this kind of feed processing is carried out at high temperature, which will destroy some material components in the feed, resulting in the destruction of the nutritional content of some components
[0005] The Publication No. CN101181024A announced by the State Intellectual Property Office on May 14, 2008, titled "Soft Pellet Compound Feed for Suckling Pigs and Processing Technology", discloses a technical solution for granulating soybeans, corn, etc. at room temperature; it is undeniable Its feed can be granulated, but those skilled in the art can be sure that it cannot achieve the hardness and taste that meet the eating habits of rodents according to its components and processes

Method used

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  • High-fat purified feed establishing metabolic syndrome animal model and processing technology
  • High-fat purified feed establishing metabolic syndrome animal model and processing technology
  • High-fat purified feed establishing metabolic syndrome animal model and processing technology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] First, weigh the respective raw materials:

[0039] Casein 20.0kg, starch 10.0kg, sucrose 20.0kg, vegetable oil 3.0kg, animal fat 22.0kg, cellulose 6.0kg,

[0040] L-cystine 0.5 kg, dicalcium phosphate 2.0 kg, calcium carbonate 1.0 kg, potassium citrate 2.0 kg, choline bitartrate 0.25 kg, complex minerals 2.0 kg, complex vitamins 1.5 kg and maltodextrin 12.0 kg.

[0041] A total of 102.25 kg.

[0042] Second, mix 3.0 kg vegetable oil and 22.0 kg animal fat, then add 12.27 kg of water to the mixture, stir evenly to form a semi-fluid fat material, and set aside;

[0043] Third, mix and stir the rest of the raw materials evenly; gradually add to the aforementioned semi-fluid fat material, and mix evenly;

[0044] Fourth, under the condition of 25°C, the cylindrical pellet feed with a diameter of 12mm and a length of 20mm is made by a granulator;

[0045] Fifth, use dehumidification equipment to dry at an ambient temperature of 18°C ​​until the water content is 9%, and t...

Embodiment 2

[0048] First, weigh the respective raw materials:

[0049] Casein 22.0kg, starch 9.0kg, sucrose 19.0kg, vegetable oil 2.5kg, animal fat 20.0kg, cellulose 5.5kg,

[0050]L-cystine 0.3 kg, dicalcium phosphate 1.5 kg, calcium carbonate 0.8 kg, potassium citrate 1.7 kg, choline bitartrate 0.20 kg, complex minerals 1.5 kg, complex vitamins 1.2 kg and maltodextrin 11.0 kg.

[0051] A total of 96.20 kg.

[0052] Second, mix 2.5kg vegetable oil and 20.0 kg animal fat, then add 7.697kg of water to the mixture, stir evenly to be a semi-fluid fat material, and set aside;

[0053] Third, mix and stir the rest of the raw materials evenly; gradually add to the aforementioned semi-fluid fat material, and mix evenly;

[0054] Fourth, under the condition of 32°C, a cylindrical pellet-shaped feed with a diameter of 15mm and a length of 25mm is made by a granulator;

[0055] Fifth, use dehumidification equipment to dry at an ambient temperature of 25°C until the moisture content is 7%, and th...

Embodiment 3

[0058] First, weigh the respective raw materials:

[0059] Casein 25.0kg, starch 8.0kg, sucrose 18.0kg, vegetable oil 2.0kg, animal fat 18.0kg, cellulose 5.0kg,

[0060] L-cystine 0.2 kg, dicalcium phosphate 1.0 kg, calcium carbonate 0.5 kg, potassium citrate 1.5 kg, choline bitartrate 0.15 kg, complex minerals 1.0 kg, complex vitamins 1.0 kg and maltodextrin 10.0 kg.

[0061] A total of 91.35 kg.

[0062] Second, mix 2.0 kg vegetable oil and 18.0 kg animal fat, then add 4.568 kg of water to the mixture, stir evenly to become a semi-fluid fat material, and set aside;

[0063] Third, mix and stir the rest of the raw materials evenly; gradually add to the aforementioned semi-fluid fat material, and mix evenly;

[0064] Fourth, under the condition of 29 ℃, the feed of cylindrical pellets with a diameter of 13mm and a length of 22mm is made by a granulator;

[0065] Fifth, use dehumidification equipment to dry at an ambient temperature of 20°C until the water content is 6%, and...

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Abstract

The invention discloses high-fat purified feed establishing a metabolic syndrome animal model and a processing technology, wherein the high-fat purified feed has good stability, conforms to the eating habits of rodents and ensures that the designed ingredients are not damaged. The high-fat purified feed comprises the following raw materials in parts by weight: 20.0-25.0 parts of casein, 8.0-10.0 parts of starch, 18.0-20.0 parts of sucrose, 2.0-3.0 parts of vegetable oil, 18.0-22.0 parts of animal fat, 5.0-6.0 parts of cellulose, 0.2-0.5 part of L-cystine, 1.0-2.0 parts of dicalcium phosphate, 0.5-1.0 part of calcium carbonate, 1.5-2.0 parts of potassium citrate, 0.15-0.25 part of choline bitartrate, 1.0-2.0 parts of composite minerals, 1.0-1.5 parts of vitamin complex and 10.0-12.0 parts of maltodextrin. The high-fat purified feed disclosed by the invention has good stability and balanced nutrition and is suitable for rodents.

Description

technical field [0001] The invention relates to the technical field of building medical models, in particular to a high-fat purified feed and a processing technology for building metabolic syndrome animal models. Background technique [0002] At present, the incidence of metabolic syndrome in my country is greater than 15%, with more than 200 million patients. According to the results of a random sample survey of Chinese adults, the prevalence rates of metabolic syndrome among overweight and obese people are 21.6% and 29.6%, respectively. Metabolic syndrome has become a new chronic disease and public health problem. The high incidence of metabolic syndrome has brought a heavy burden to society and economy, and it is a worldwide problem that seriously threatens human health. In order to study the pathogenesis of metabolic diseases in depth, researchers urgently need to establish rodent models with the physiological changes characteristic of metabolic syndrome. Currently, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K1/18A23K1/16A23K1/175
Inventor 马剑
Owner JIANGSU MEIDISEN BIOLOGICAL MEDICINE
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