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Starch-based hydrogel carrier material for controlling slow-release, and preparation method and application thereof

A carrier material, hydrogel technology, applied in pharmaceutical formulations, drug delivery and other directions, can solve the problems of difficult control of cross-linking reaction, achieve good controlled release effect, simple process and good biocompatibility.

Active Publication Date: 2014-06-11
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] It can be seen from the above materials that the preparation of hydrogels is mostly obtained by chemical cross-linking, but the cross-linking agents used therein have their own shortcomings. Although organic small molecule cross-linking agents can form strong covalent bonds, most of them have Biological toxicity, strict separation operation is required to remove it
Most macromolecular cross-linking agents are biologically non-toxic and degradable. Although they can overcome the shortcomings of small-molecular cross-linking agents, the cross-linking reaction is difficult to control

Method used

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  • Starch-based hydrogel carrier material for controlling slow-release, and preparation method and application thereof
  • Starch-based hydrogel carrier material for controlling slow-release, and preparation method and application thereof
  • Starch-based hydrogel carrier material for controlling slow-release, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Deployment of moisture content of starch samples

[0022] Weigh a certain amount of waxy cornstarch in a beaker, spray a certain amount of water into a starch sample with a water content of 25%, mix well and set aside;

[0023] (2) Microwave modification of starch and preparation of starch-based hydrogel controlled release carrier material

[0024] Weigh a certain amount of starch sample with a good moisture content and put it into the reaction tank, seal it and put it into the cavity of the microwave reaction system, control the microwave action temperature at 100°C, microwave action power 1000w, and microwave action time 120min , cooled to below 50°C, took out the starch sample and put it in an oven at 40°C to dry for 12 hours, and passed through an 80-mesh sieve to obtain the starch-based hydrogel controlled-release carrier material.

[0025] (3) Preparation of starch-based hydrogel matrix tablets

[0026] Weigh a certain amount of starch-based hydrogel control...

Embodiment 2

[0034] (1) Deployment of moisture content of starch samples

[0035] Weigh 500g of high-chain corn starch (G50) into a beaker, spray a certain amount of water to make a starch sample with a water content of 15%, mix well and set aside;

[0036] (2) Microwave modification of starch and preparation of starch-based hydrogel controlled release carrier material

[0037] Put the prepared high-chain corn starch (G50) sample into the reaction tank, seal it and put it into the cavity of the microwave reaction system, control the microwave temperature at 140°C, the microwave power of 800w, and the microwave time of 60min to end the reaction After cooling down to below 50°C, the starch sample was taken out and placed in an oven at 40°C to dry for 12 hours, and passed through an 80-mesh sieve to obtain the starch-based hydrogel controlled-release carrier material.

[0038] (3) Preparation of starch-based hydrogel matrix tablets

[0039] Using pancreatin as a model food functional factor...

Embodiment 3

[0048] (1) Deployment of moisture content of starch samples

[0049] Weigh 1000g of mung bean starch in a beaker, spray a certain amount of water into a starch sample with a water content of 95%, mix well and set aside;

[0050] (2) Microwave modification of starch and preparation of starch-based hydrogel controlled release carrier material

[0051] Put the mung bean starch prepared with water into the reaction tank, seal it and put it into the cavity of the microwave reaction system, control the microwave action temperature at 60°C, microwave action power 600w, microwave action time 30min, after the end of the reaction, cool to 50°C Next, the starch sample was taken out and dried in an oven at 40° C. for 12 hours, and passed through an 80-mesh sieve to obtain the starch-based hydrogel controlled-release carrier material.

[0052] (3) Preparation of starch-based hydrogel matrix tablets

[0053] After mixing the obtained starch-based hydrogel controlled and sustained-release ...

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Abstract

The invention discloses a starch-based hydrogel carrier material for controlling slow-release, and a preparation method and an application thereof. The preparation method comprises the following steps: adding distilled water into the starch to prepare a starch sample with 15 to 95 % of moisture content, putting the starch sample into a reacting tank, processing by microwave after sealing the reacting tank, cooling to below 50 DEG C after processing, drying, crushing and sieving to obtain the starch-based hydrogel carrier material for controlling slow-release. The method has characteristics of environmental protection, easy operation and simple technology, and the prepared starch-based hydrogel carrier material for controlling slow-release has markedly improved disintegration performance and capacity of controlling release behavior of a release system, and can be used as a release controlling carrier in functional active substances.

Description

technical field [0001] The invention relates to the research and development of natural polymer materials in the field of controlled release of functional active substances, in particular to the microwave preparation of a starch-based hydrogel controlled-release carrier material and the effect of the starch-based hydrogel controlled-release carrier material on functional activity. Controlled release of substances. Background technique [0002] The controlled release delivery system of functional active substances such as drugs and food functional factors is an important topic in the field of controlled release materials research. Compared with traditional delivery modes, the controlled release of functional active substances has many advantages, not only can improve the activity of functional active substances The effectiveness, accuracy, safety, but also can significantly reduce its side effects and production costs. The quality of the controlled-release system of function...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/36A61K9/22
Inventor 陈玲司徒文贝赵月李晓玺李琳李冰
Owner SOUTH CHINA UNIV OF TECH
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