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Biomedical anhydrous Ca(HPO4)x(SO4)(1-x) solid solution granule and preparation method thereof

A HPO42-, biomedical technology, applied in the direction of chemical instruments and methods, applications, prostheses, etc., can solve the problems of narrow application range, inability to apply injectable bone repair materials, etc., achieve simple operation, good clinical application prospects, The effect of easy industrialization

Inactive Publication Date: 2014-07-23
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these sintered anhydrous CaSO 4 The degradation rate compared to anhydrous CaSO without sintering 4 Improved, but too narrow for use as an injectable bone repair material

Method used

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  • Biomedical anhydrous Ca(HPO4)x(SO4)(1-x) solid solution granule and preparation method thereof
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  • Biomedical anhydrous Ca(HPO4)x(SO4)(1-x) solid solution granule and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0020] 1) Add CaCl 2 and K 2 SO 4 Dissolved in deionized water, respectively prepared into solutions, mixed at room temperature according to the molar ratio of Ca / S of 1:1, the reaction was carried out under constant stirring, the reaction temperature was room temperature, and the reaction time was 2 hours. After the reaction, use Filter 3 times with deionized water, once with alcohol, and then dry at 60°C to obtain CaSO 4 2H 2 O;

[0021] 2) Dissolve 0.4g of citric acid monohydrate in 400ml of deionized water to make an electrolyte solution;

[0022] 3) 10g of CaSO obtained in step 1) 4 2H 2 0 and the electrolyte solution prepared in step 2) are mixed to obtain a suspension;

[0023] 4) Add 1g of CaHPO 4 2H 2 O and the suspension prepared in step 3) are stirred and mixed, then put into the reaction kettle, so that the molar ratio of P / S in the mixed solution is 0.1, and the reaction is carried out under the hydrothermal condition of 130°C, and the reaction time is 5 ...

Embodiment 2

[0025] 1) CaNO 3 and K 2 SO 4 Dissolved in deionized water, respectively prepared into solutions, mixed at room temperature according to the molar ratio of Ca / S of 1:1, the reaction was carried out under constant stirring, the reaction temperature was room temperature, and the reaction time was 2 hours. After the reaction, use Filter 3 times with deionized water, once with alcohol, and then dry at 60°C to obtain CaSO 4 2H 2 O;

[0026] 2) Dissolve 0.4g of citric acid monohydrate in 400ml of deionized water to make an electrolyte solution;

[0027] 3) 10g of CaSO obtained in step 1) 4 2H 2 0 and the electrolyte solution prepared in step 2) are mixed to obtain a suspension;

[0028] 4) Add 4.16g of Na 2 HPO 4 12H 2 O and the suspension prepared in step 3) are stirred and mixed and then put into the reaction kettle so that the molar ratio of P / S in the mixed solution is 0.2, and the reaction is carried out under the hydrothermal condition of 140°C, and the reaction time...

Embodiment 3

[0033] 1) Add CaCl 2 and Na 2 SO 4 Dissolved in deionized water, respectively prepared into solutions, mixed at room temperature according to the molar ratio of Ca / S of 1:1, the reaction was carried out under constant stirring, the reaction temperature was room temperature, and the reaction time was 2 hours. After the reaction, use Filter 3 times with deionized water, once with alcohol, and then dry at 60°C to obtain CaSO 4 2H 2 O;

[0034] 2) Dissolve 0.4g of citric acid monohydrate in 400ml of deionized water to make an electrolyte solution;

[0035] 3) 10g of CaSO obtained in step 1) 4 2H 2 O and the electrolyte solution prepared in step 2) are mixed to obtain a suspension;

[0036] 4) Add 2.37g of KH 2 PO 4 Stir and mix the suspension prepared in step 3) and put it into the reaction kettle so that the molar ratio of P / S in the mixture is 0.3. The reaction is carried out under hydrothermal conditions at 150°C, and the reaction time is 3 hours. The reacted sample w...

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Abstract

The invention discloses an anhydrous Ca(HPO4)x(SO4)(1-x) solid solution granule and a preparation method thereof. Part of SO4<2-> in CaSO4 is replaced by HPO4<2-> by adopting a wet chemical method and heat treatment to obtain the anhydrous Ca(HPO4)x(SO4)(1-x) solid solution granule with adjustable compositions and proportions. The anhydrous Ca(HPO4)x(SO4)(1-x) solid solution granule prepared by the preparation method disclosed by the invention can be widely applied to the fields of biomedical materials such as bone filling materials and bone cement.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, in particular to an anhydrous Ca(HPO 4 ) x (SO 4 ) 1-x Solid solution particles and preparation method thereof. Background technique [0002] Calcium sulfate has been used as an artificial bone repair material for hundreds of years, and its good biocompatibility, osteoconductivity, and biodegradable and absorbable properties make it a research hotspot for inorganic bone repair materials and is widely used in bone repair. . [0003] Anhydrous CaSO 4 , CaSO 4 1 / 2H 2 O and CaSO 4 2H 2 O. The three can be transformed into each other under certain conditions. Although clinical practice and experimental results show that anhydrous CaSO 4 The outstanding advantage is that it can be degraded and absorbed in the body, and its degradation products do not interfere with new bone formation, but there are problems such as too fast degradation and absorption, and lack of necessary mech...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B25/32C01F11/46A61L27/12A61L27/50A61L24/02
Inventor 程逵章华勇翁文剑
Owner ZHEJIANG UNIV
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