Inhalation formulation containing n-acetyl-l-cysteine and fluticasone propionate and process for its preparation
A technology of fluticasone propionate and cysteine, which is applied in the field of drugs for the treatment of respiratory diseases, especially asthma, can solve the problems of large dosage, achieve the effect of improving airway remodeling and good therapeutic effect
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0035] Dissolve 80 mg of fluticasone propionate and 1 g of N-acetyl-L-cysteine in ethanol. After filtration, the filtrate is spray-dried and micronized to make the average particle size reach 2 μm. 10 g of lactose is micronized to the average particle size by a flow energy mill 20μm, after mixing, pass through a 200-mesh sieve for 3 times, mix evenly, and pack in No. 3 capsules. Fluticasone propionate 80μg, N-acetyl-L-cysteine 1mg per capsule
[0036] The process conditions are: the inlet temperature is 105°C, the outlet temperature is 68, the air flow rate is 90%, the inner diameter of the nozzle outlet is 0.1cm, the air flow rate of the nozzle is 800ml / min, and the injection speed is 50mL / h
Embodiment 2-1
[0038] Dissolve 250mg of fluticasone propionate and 2500mg of N-acetyl-L-cysteine in ethanol. After filtering, the filtrate is spray-dried and micronized to make the average particle size reach 4μm. Lactose 40g is micronized to the average particle size by a fluid energy mill. The diameter is 30 μm, mix well, mix well with 200 mesh sieve for 3 times, then pack into No. 3 capsules. Each capsule contains fluticasone propionate 250μg, N-acetyl-L-cysteine 2500μg.
[0039] The process conditions are as follows: inlet temperature is 105°C, outlet temperature is 68°C, air flow rate is 90%, nozzle outlet inner diameter is 0.1cm, nozzle air flow rate is 800ml / min, and sample injection speed is 50mL / h.
Embodiment 2-2
[0041] According to the formulation of Example 2-1, the carrier was changed to octaacetate-D-cellobiose octaacetate with an average particle size of 35 μm, and the powder spray was prepared according to the process of Example 2-1.
PUM
Property | Measurement | Unit |
---|---|---|
particle diameter | aaaaa | aaaaa |
particle diameter | aaaaa | aaaaa |
particle diameter | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com