Chinese medicine composition as well as preparation method and application thereof

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition and its preparation, can solve the problems of poor curative effect and single curative effect, and achieve the effects of avoiding the influence of heat, shortening the process flow, and avoiding mold

Active Publication Date: 2014-01-08
广东全瑞医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The first purpose of the embodiments of the present invention is to provide a traditional Chinese medicine composition, which aims to solve the problem that the existing traditional Chinese medicine composition has poor curative effect in treating Qi and blood deficiency syndrome, and the curative effect is relatively single
[0004] The second purpose of the embodiment of the present invention is to provide a preparation method of a traditional Chinese medicine composition, aiming to solve the problem that the curative effect of the products prepared by the existing traditional Chinese medicine composition preparation method is not good and the curative effect is relatively single

Method used

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  • Chinese medicine composition as well as preparation method and application thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0023] Weigh 35 parts of astragalus, 6 parts of angelica, 45 parts of Rehmannia glutinosa, 5 parts of peony, 3 parts of ligusticum, and 6 parts of comfrey by weight, 300g in total, grind into coarse powder, soak for 8 hours, and use 10 times the amount of 75% Ethanol percolation extraction, collecting percolation liquid, recovering ethanol under reduced pressure and concentrating to 35°C relative density of 1.23 extract, using 10% sodium bicarbonate to adjust the pH value to 5.5, then adding 2 times the amount of water and 2 times Ethyl acetate, 3 times the amount of 90% ethanol as eluent, separated and purified by PHD100 (styrene-type non-polar copolymer) macroporous adsorption resin column chromatography, the sample amount is the weight of the extract: PHD100 macroporous adsorption Resin=1.0:1.5, collect and combine the three eluents, filter, add 1.8% cyclodextrin, 1.5% Opadry and 1.4% colloidal silica to the filtrate, stir well After spray drying, dry cream powder is obtain...

Embodiment 2

[0025] Weigh 41 parts of astragalus, 8 parts of angelica, 35 parts of Rehmannia glutinosa, 6 parts of peony, 4 parts of Ligusticum edulis, and 6 parts of comfrey by weight, 300g in total, grind into coarse powder, soak for 20 hours, use 8 times the amount of 90% Ethanol percolation extraction, collecting the percolation liquid, recovering ethanol under reduced pressure and then concentrating to the extract with a relative density of 1.29 at 50°C. The amount of ethyl acetate and 3 times the amount of 90% ethanol were used as the eluent, separated and purified by PHD100 macroporous adsorption resin column chromatography, and the sample amount was the weight of the extract: PHD100 macroporous adsorption resin=1.0:1.5, collected and combined for three A kind of eluent, filtered, and 4.0% cyclodextrin, 0.5% Opadry and 0.9% colloidal silicon dioxide were added to the filtrate by the total weight of raw materials, and the mixture was fully stirred and then spray-dried to obtain a dry ...

Embodiment 3

[0027] Weigh 37 parts of astragalus, 7 parts of angelica, 37 parts of Rehmannia glutinosa, 7 parts of peony, 5 parts of ligusticum, and 7 parts of comfrey by weight, 300g in total, grind into coarse powder, soak for 15 hours, use 6 times the amount of 85% Ethanol percolation extraction, collecting percolation liquid, recovering ethanol under reduced pressure and concentrating to 55°C relative density of 1.36 extract, using 10% sodium bicarbonate to adjust the pH value to 6.5, then adding 2 times the amount of water and 2 times The amount of ethyl acetate and 3 times the amount of 90% ethanol were used as the eluent, separated and purified by PHD100 macroporous adsorption resin column chromatography, and the sample amount was the weight of the extract: PHD100 macroporous adsorption resin=1.0:1.5, collected and combined for three A kind of eluent, filter, add 2.8% cyclodextrin, 1.1% Opadry and 2.3% colloidal silicon dioxide of the total weight of raw materials to the filtrate, st...

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Abstract

The invention provides a Chinese medicine composition as well as a preparation method and application thereof. The Chinese medicine composition is a medicament which is prepared from the following raw materials in parts by weight: 35-45 parts of astragalus mongholicus, 6-9 parts of Chinese angelica, 35-45 parts of prepared rehmannia roots, 5-10 parts of Chinese herbaceous peony, 2-8 parts of ligusticum, and 5-10 parts of lithospermum. The preparation method of the Chinese medicine composition comprises the following steps: weighing the raw materials to be smashed, and extracting percolate with ethanol solutions of different concentrations; collecting the percolate, reducing the pressure, concentrating the percolate into extract after the ethanol solutions are recovered, carrying out the chromatography, the separation and the purification with macroreticular resin PHD 100, collecting and compounding eluant, filtering the eluant, adding cyclodextrin, Opadry and colloidal silicon dioxide into the filtrate to be sufficiently and uniformly mixed, carrying out spray drying to obtain dry paste powder, adding glyceryl behenate into the dry paste powder to be uniformly mixed, carrying out filling and polishing, and packaging the resultant with aluminium-plastic to obtain capsules. The Chinese medicine composition provided by the invention is used for treating qi and blood deficiency syndromes as well as alopecia caused by qi and blood deficiency syndromes or chemotherapies.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine composition and its preparation method and application. Background technique [0002] With the acceleration of the pace of life, the increase of life pressure and the aggravation of environmental pollution, the incidence of qi and blood deficiency syndrome in the society is increasing year by year. According to reports, the incidence rate of men is 20%, and the incidence rate of women is 47%. The potential incidence rate of the following adolescents and children is as high as 69%. Among the above-mentioned groups, the incidence rate of women is much higher than that of men. Among them, the incidence rate of female children is 2.7% higher than that of men, while the incidence rate of adult females is 10.2% higher than that of men. . The common symptoms of Qi and blood deficiency syndrome are pale or lacklustre lips, dizziness...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/804A61P17/14
Inventor 张凯谢雁鸣伍彪
Owner 广东全瑞医药有限公司
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