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Application of Gypensapogenin A in medicaments for vasodilator

A vasodilator and drug technology, applied in the application field of Gypensapogenin A in vasodilator drugs, can solve problems such as no breakthrough progress

Inactive Publication Date: 2013-01-16
JIANGSU KANGHENG CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment of hypertension and its related vascular complications and / or complications mainly relies on western medicine, but there has been no breakthrough in the treatment of hypertension with traditional Chinese medicine

Method used

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  • Application of Gypensapogenin A in medicaments for vasodilator
  • Application of Gypensapogenin A in medicaments for vasodilator
  • Application of Gypensapogenin A in medicaments for vasodilator

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: the preparation of the compound Gypensapogenin A tablet involved in the present invention:

[0017] Take 20 grams of compound Gypensapogenin A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tabletting machine.

Embodiment 2

[0018] Embodiment 2: The preparation of the compound Gypensapogenin A capsules involved in the present invention:

[0019] Get 20 grams of compound Gypensapogenin A, add conventional auxiliary materials such as starch 180 grams for the preparation of capsules, mix well, and pack into capsules to make 1000 tablets.

[0020] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0021] Experimental Example 1 Preparation of Rat Isolated Aortic Ring

[0022] Experimental steps:

[0023] Clean grade male Sprague=Dawley (SD) rats, weighing 240~260g.

[0024] Rapidly dissociate the thoracic aorta of SD rats and place at 4°C containing 95% O 2 and 5%CO 2 In the K-H liquid pre-saturated with mixed gas, the surrounding connective tissue was removed and cut into vascular rings of 3-4mm. During this period, care should be taken to protect the intima of the vascular ring from damage. According to the needs of the experiment, the method of rubbing the inner surface of the vascular ring with a cotton swab was used to prepare a part of the vascular ring as a model in which the endothelium was removed. Then the vascular ring was suspended in a bath pre-prepared with 10mL K-H solution, one end was fixed, and the other end was connected to the Medlab biological signal acquisition system through a tension transducer. In continuous pass 95%O 2 and 5%CO 2 In the st...

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Abstract

The invention provides an application of Gypensapogenin A in preparing medicaments for vasodilator,and in particular relates to the applications of Gypensapogenin A in preparing medicaments for blood pressure and resisting angor pectoris and other angiopathies. The application of Gypensapogenin A in preparing medicaments for vasodilator, involved in the invention, is disclosed for the first time. As the skeleton is brand new, and the strong activity of Gypensapogenin B on vasodilator is unexpectedly strong, the possibility that any enlightenments are given by other compounds does not exist. Gypensapogenin A has prominent substantive features and has notable progress when being used for vasodilator.

Description

technical field [0001] The invention relates to the application of the compound Gypensapogenin A, mainly relates to the application of the compound Gypensapogenin A in the preparation of vasodilator drugs, which is suitable for the preparation of blood pressure lowering drugs and antiangina pectoris drugs. technical background [0002] In my country, hypertension is a common cardiovascular disease with a high prevalence rate, and the complications and / or comorbidities of heart, brain, kidney, limbs and other vascular complications and / or comorbidities rank first among all kinds of diseases , is extremely harmful to human health. According to the results of the national census in 1991, the prevalence of hypertension in my country increased by 275% within 13 days. At present, the treatment of hypertension and its related vascular complications and / or comorbidities mainly relies on western medicine, but there has been no breakthrough in the treatment of hypertension with tradit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61P9/08A61P9/12A61P9/10
Inventor 王慧张广吴俊华
Owner JIANGSU KANGHENG CHEM
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