Mollugin and preparation method and application thereof
A kind of rubidin and grassland technology, which is applied in the preparation of drugs for treating diabetes and the application of drugs for lowering blood sugar. In the field of rubidin and its preparation, it can solve the pharmacological activity of rubidin. No research report has been found and other problems, to achieve a good hypoglycemic effect, a significant effect, and the effect of lowering blood sugar levels
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Embodiment 1
[0020] The rubiacin in this example is obtained by extracting and eluting from madder, and the specific preparation method is as follows: take the dried madder medicinal material, heat and reflux with 5 times the amount of petroleum ether for extraction for 40 minutes; recover the petroleum ether, and dry it in vacuum The petroleum ether was removed to obtain the extract; the extract was subjected to silica gel 200-300 mesh column chromatography, eluted with petroleum ether, detected by TLC, combined with components rich in rubidin, and then subjected to Sephadex LH-20 gel column chromatography, using Chloroform:petroleum ether:methanol=5:5:1 for elution, and then through silica gel H column decompression column chromatography, eluting with petroleum ether, and finally recrystallizing with hot ethanol to obtain rubiacin.
Embodiment 2
[0022] The rubiacin in this example is obtained by extracting and eluting from madder, and the specific preparation method is as follows: take the dried madder medicinal material, heat and reflux with 10 times the amount of petroleum ether for extraction for 30 minutes; recover petroleum ether, and vacuum-dry The petroleum ether was removed to obtain the extract; the extract was subjected to silica gel 200-300 mesh column chromatography, eluted with petroleum ether, detected by TLC, combined with components rich in rubidin, and then subjected to Sephadex LH-20 gel column chromatography, using Chloroform:petroleum ether:methanol=5:5:1 for elution, and then through silica gel H column decompression column chromatography, eluting with petroleum ether, and finally recrystallizing with hot ethanol to obtain rubiacin.
Embodiment 3
[0024] The rubiacin in this example is obtained by extracting and eluting from madder. The specific preparation method is as follows: take the dried madder medicinal material, heat and reflux with 15 times the amount of petroleum ether to extract for 20 minutes; recover the petroleum ether, and dry it in vacuum The petroleum ether was removed to obtain the extract; the extract was subjected to silica gel 200-300 mesh column chromatography, eluted with petroleum ether, detected by TLC, combined with components rich in rubidin, and then subjected to Sephadex LH-20 gel column chromatography, using Chloroform:petroleum ether:methanol=5:5:1 for elution, and then through silica gel H column decompression column chromatography, eluting with petroleum ether, and finally recrystallizing with hot ethanol to obtain rubiacin.
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