Composition for producing a temporary intestinal occlusion

A composition and blockage technology, which are applied in the fields of enteroscopy and intestinal surgery, and can solve the problems of difficult and long surgical procedures, danger, and patient infection.

Active Publication Date: 2013-01-16
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AI-Extracted Technical Summary

Problems solved by technology

[0003] Especially in colonoscopic surgery on the intestinal tract of humans and animals, complications often arise due to the location where excreta are examined and/or processed intraoperatively, despite previous administrat...
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Abstract

The present invention relates to the use of a solidifiable composition for producing a temporary occlusion of the intestine of a mammal, wherein the composition is flowable and solidifiable to form a solid plug at a desired location in the intestine. The structure of said plug can be modified for the subsequent, at least partial removal of the occlusion.

Application Domain

Surgical adhesives

Technology Topic

Intestinal occlusionChemistry +2

Image

  • Composition for producing a temporary intestinal occlusion
  • Composition for producing a temporary intestinal occlusion
  • Composition for producing a temporary intestinal occlusion

Examples

  • Experimental program(41)

Example

[0053] Examples 1 and 2 - two component system
[0054] A hydrocolloid solution or suspension of the swollen polymer at a concentration close to the gel point, referred to as Formulation A, was pumped to the desired blockage site via a conventional endoscope. A sufficient amount of flowable gelling agent of Formulation B is dispensed through the same or a second catheter of the endoscope to the same location inside the intestinal tract. Viscosity and pump pressure are selected in such a way that, on the one hand, the two formulations can be transported quickly to the target location in order to prevent too drastic temperature changes of the respective formulations in the ducts, and, on the other hand, to ensure a rapid transport of the two formulations. Mix to prevent large amounts of both fluids from draining from the blockage.

Example Embodiment

[0055] Example 1: The polymer itself acts as a gelling agent
[0056] The formulations A and B are colloidal solutions of agar-agar, gelatin, carrageen, etc., in which, optionally, chemical deformations are carried out, said random deformations, such as accelerated completion of temperature changes , the colloid-to-sol transition takes place in this temperature change, hereinafter referred to as "gelling agent temperature", which generally corresponds to 35°C in the case of gelatin and 45°C in the case of agar, Or in order to improve the solubility, in addition, a solid colloid of 1% solution can be formed first. Alternatively or additionally, surfactants such as non-ionic surfactants such as copolymers of ethylene oxide and propylene oxide may be added, or another suitable solvent may be added as solubility promoters, which Solvents have the effect of gelling only at higher concentrations.
[0057] Without the addition of such co-solvents, Formulation A can be an aqueous solution at concentrations just below the gel point, e.g., a maximum of about 0.9% solution, while Formulation B can be an aqueous solution at higher concentrations at temperatures above the above-mentioned gel temperature. For aqueous solutions, the higher temperature depends on the amounts of the two ingredients and the rate of mixing. For example, 100 ml of 0.9% Formulation A and 10 ml of hot 15% Formulation B are applied simultaneously to the blockage. "Hot" as used in this connection means that the temperature is high enough to ensure that, while cooling may occur inside the catheter of the endoscope, when excreted from the endoscope into the intestinal lumen, The temperature of the solution is above the gelation temperature to prevent gelation within the catheter. Depending on the flow rate, the length of the flow-through path, and the degree of heat exchange between the transported solution and the material of the conduit, a temperature of 50°C to 60°C at the point of entry into the conduit should be sufficient. Preferably, the temperature is only slightly off, eg <5°C, above the gelling temperature at the exchange site, so that cooling can occur quickly enough to form a plug, and also to prevent excess solution from flowing further down.
[0058] At a concentration higher than the gelling concentration and at a temperature lower than the gelling temperature, the two solutions produce a mixture such that the polymer immediately forms a solid colloidal plug about 4 to 5 cm in diameter, in each Positionally blocked bowel.
[0059] Alternatively, water or saline can be used as formulation B. In this case, by pumping the polymer solution as Formulation A onto the plugging site at a concentration significantly above the gelling value, for example a 5% solution, and at a temperature above the gelling temperature, and Gelation is induced by supplying water at normal temperature or lower temperature, for example, 10 to 15° C., so as to quickly form a mixture at a temperature lower than the gelation temperature.

Example Embodiment

[0060] Embodiment 2: add gelling agent
[0061] As described in Example 1, Formulation A is an approximately 0.9% solution of gelatin, agar, or similar optionally modified polypeptide or polysaccharide, and Formulation B is a separate gelling agent, such as saturated saline. The two components are mixed, the polymer having a lower solubility than in salt, such that the polymer coagulates and coagulates to form the desired plug.

PUM

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Description & Claims & Application Information

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