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Composition for producing a temporary intestinal occlusion

A composition and blockage technology, which are applied in the fields of enteroscopy and intestinal surgery, and can solve the problems of difficult and long surgical procedures, danger, and patient infection.

Active Publication Date: 2013-01-16
G·比索夫
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Especially in colonoscopic surgery on the intestinal tract of humans and animals, complications often arise due to the location where excreta are examined and / or processed intraoperatively, despite previous administration of a laxative that not only Makes the surgical procedure more difficult and lengthy, and also poses a risk of infection to the patient during surgical procedures, for example, to obtain tissue samples or to remove tissue

Method used

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  • Composition for producing a temporary intestinal occlusion
  • Composition for producing a temporary intestinal occlusion
  • Composition for producing a temporary intestinal occlusion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 and 2

[0053] Examples 1 and 2 - two component system

[0054] A hydrocolloid solution or suspension of the swollen polymer at a concentration close to the gel point, referred to as Formulation A, was pumped to the desired blockage site via a conventional endoscope. A sufficient amount of flowable gelling agent of Formulation B is dispensed through the same or a second catheter of the endoscope to the same location inside the intestinal tract. Viscosity and pump pressure are selected in such a way that, on the one hand, the two formulations can be transported quickly to the target location in order to prevent too drastic temperature changes of the respective formulations in the ducts, and, on the other hand, to ensure a rapid transport of the two formulations. Mix to prevent large amounts of both fluids from draining from the blockage.

Embodiment 1

[0055] Example 1: The polymer itself acts as a gelling agent

[0056] The formulations A and B are colloidal solutions of agar-agar, gelatin, carrageen, etc., in which, optionally, chemical deformations are carried out, said random deformations, such as accelerated completion of temperature changes , the colloid-to-sol transition takes place in this temperature change, hereinafter referred to as "gelling agent temperature", which generally corresponds to 35°C in the case of gelatin and 45°C in the case of agar, Or in order to improve the solubility, in addition, a solid colloid of 1% solution can be formed first. Alternatively or additionally, surfactants such as non-ionic surfactants such as copolymers of ethylene oxide and propylene oxide may be added, or another suitable solvent may be added as solubility promoters, which Solvents have the effect of gelling only at higher concentrations.

[0057] Without the addition of such co-solvents, Formulation A can be an aqueous so...

Embodiment 2

[0060] Embodiment 2: add gelling agent

[0061] As described in Example 1, Formulation A is an approximately 0.9% solution of gelatin, agar, or similar optionally modified polypeptide or polysaccharide, and Formulation B is a separate gelling agent, such as saturated saline. The two components are mixed, the polymer having a lower solubility than in salt, such that the polymer coagulates and coagulates to form the desired plug.

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Abstract

The present invention relates to the use of a solidifiable composition for producing a temporary occlusion of the intestine of a mammal, wherein the composition is flowable and solidifiable to form a solid plug at a desired location in the intestine. The structure of said plug can be modified for the subsequent, at least partial removal of the occlusion.

Description

technical field [0001] The present invention relates to the field of medical endoscopy and endo-surgery, more specifically, the present invention relates to the field of enteroscopy and entero-surgery. Background technique [0002] Endoscopy has been a widely accepted diagnostic procedure in humans as well as in veterinary medicine for many years. Endoscopies for such procedures have been continuously developed, and today they can be used not only for illuminating or imaging the interior of the body (eg using fiber optics), but also for minimally invasive preparations. In addition to optical fibers, modern endoscopy includes, for example, air insufflators or air pumps, irrigators, suction pumps, and bendable tools such as cannulas or cutting tools for injection, clamping, or Coagulated wire electrodes were obtained using the current method. The endoscopy has several catheters for the introduction of the medical tools required for each surgical procedure. [0003] Especial...

Claims

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Application Information

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IPC IPC(8): A61L24/00A61L24/04
CPCA61L24/001A61L24/04
Inventor G·比索夫
Owner G·比索夫
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