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Cefonicid compound-containing medicinal composition and its preparation method
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A technology of cefonicil and composition, which is applied in the field of medicine and can solve the problems of few types of excipients and many components of excipients
Active Publication Date: 2015-07-01
罗诚
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Abstract
Description
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Problems solved by technology
[0004] The purpose of the present invention is to provide a cefnixime pharmaceutical composition with good stability and few types of adjuvant for the problem of many adjuvant components in the prior art
Method used
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Embodiment 1
[0014] Formulation: The pharmaceutical composition of the present invention includes the following components: 20 g of cefonicid, 1 ml of benzyl alcohol, and the volume is made up to 100 ml with water.
[0015] Weigh 20 g of cefonicid, weigh 1 ml of benzyl alcohol, dissolve cefonicid with an appropriate amount of water for injection and benzyl alcohol, make up the volume with water for injection, adjust the pH to 7.0 with citric acid and disodium hydrogen phosphate buffer solution, add activated carbon 0.01% (W / V) for decolorization, sterilization by filtration through a 0.22 μm filter membrane, and aliquoting.
Embodiment 2
[0017] Formulation: the pharmaceutical composition of the present invention comprises the following components: 100 g of cefonicid, 5 ml of benzyl alcohol, and the volume is made up to 100 ml with water.
[0018] Weigh 100 g of cefonicid, weigh 5 ml of benzyl alcohol, dissolve cefonicid with appropriate amount of water for injection and benzyl alcohol, make up to volume with water for injection, adjust pH to 7.5 with citric acid and disodium hydrogen phosphate buffer solution, add activated carbon 0.5% (W / V) for decolorization, filter sterilization with 0.22 μm filter membrane, and dispense.
Embodiment 3
[0020] Formulation: the pharmaceutical composition of the present invention includes the following components: 30 g of cefonicid, 2 ml of benzyl alcohol, and the volume is made up to 100 ml with water.
[0021] Weigh 30 g of cefonicid, weigh 2 ml of benzyl alcohol, dissolve cefonicid with appropriate amount of water for injection and benzyl alcohol, make up to volume with water for injection, adjust pH to 6.5 with citric acid and disodium hydrogen phosphate buffer solution, add activated carbon 0.01% (W / V) for decolorization, sterilization by filtration through a 0.22 μm filter membrane, and aliquoting.
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Abstract
The invention provides a cefonicid compound-containing medicinal composition and its preparation method. The cefonicid injection provided by the invention comprises, in terms of every 10ml: 2-10g of cefonicid and 0.1-0.5m1 of benzyl alcohol. In the invention, cefonicid is prepared into an injection agent, which only contains a small amount of benzyl alcohol, and the auxiliary material consumption is reduced. Besides, the preparation method is simple and the cost is low. The cefonicid injection provided in the invention has improved stability and medication safety. The inventor of the invention selects benzyl alcohol from a large number of auxiliary materials, and determines the best content through a lot of experiments. With the content, the pain suffered by patients during injection can be alleviated. And benzyl alcohol at the content can be rapidly absorbed by the body, so that accumulation of benzyl alcohol in muscles cannot be resulted and muscle spasms cannot be caused.
Description
technical field [0001] The invention relates to the field of medicine, in particular to a pharmaceutical composition containing a cefonicid compound and a preparation method thereof. Background technique [0002] Cefonicid is a second-generation cephalosporin for intravenous or intramuscular injection. Compared with the first-generation cephalosporins, the antibacterial effect of cefonicil sodium has a broad-spectrum anti-gram-negative bacilli effect. The effects of Citrobacter and Enterobacter are better, but they are less effective against indole-positive Proteus. Cefonicid sodium has a good effect on Haemophilus influenzae and Neisseria gonorrhoeae. However, cefonicid sodium is resistant to Streptococcus faecalis, penicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis strains, Pseudomonas spp., Serratia spp. and Acetobacter spp. [0003] The patent document CN201010151403.8 discloses a preparation method of a freeze-dried powder injection containing ...
Claims
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Application Information
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