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Immune imprinting nutritional composition

A nutritional composition, the technology of the composition, applied in the field of infant nutrition, can solve the problems of no effect on the incidence rate, no long-term effect, no effect of showing the incidence of repeated stridor, etc.

Active Publication Date: 2013-01-30
NV NUTRICIA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, to date, human trials investigating the use of probiotics for the prevention of allergic disease in high-risk children have found no effect on the incidence of asthma or asthma-like symptoms in later life, and have no effect over the time the composition is administered long-term effect
[0004] Two preventive studies investigating the effects of probiotics in healthy infants at high risk of allergic disease showed no effect on the incidence of recurrent wheezing at 1-2 years of age (Taylor et al, 2007, J Allerg Clin Immunol 119 :184-191; Abrahamsson et al, 2007, JAllerg Clin Immunol 119:1174-1180), and one study even showed an increased incidence of recurrent episodes (≥5) of wheezing bronchitis in the probiotic group (Kopp et al al, 2008, Pediatrics 121:e850-e.856)

Method used

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  • Immune imprinting nutritional composition

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Experimental program
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Effect test

Embodiment 1

[0055] Ninety full-term infants were recruited, aged 0-7 months, meeting the Hanifin and Rajka criteria for atopic dermatitis. Admission criteria include atopic dermatitis scoring system (SCORAD) score> 15. No formula was fed at the time of joining, no other major medical problems, and no probiotics or immunomodulatory drugs were used 4 weeks before joining. Written informed consent was obtained from the parents of all participants.

[0056] Participants randomly received an extensively hydrolyzed whey-based formula containing additional synbiotics (Nutrilon Nutricia, Zoetermeer, the Netherlands) as the test composition, or the same formulation without synbiotics as a placebo for 12 weeks. The investigator, the participant’s own physician, and parents were unaware of the treatment group. One year after the intervention was started, the participants returned for follow-up, which was performed by the same investigator, who was still unaware of the treatment group. In this interv...

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Abstract

The present invention relates to the use of Bifidobacterium breve for reduction of asthma and asthma like symptoms later in life and in reducing use of asthma medication.

Description

Technical field [0001] The present invention relates to infant nutrition including probiotics, which has a long-term effect on the immune system, especially asthma, beyond the time that the composition has been administered; and / or it can avoid the drug treatment of asthma. Background technique [0002] In the past few decades, the incidence of allergic diseases in Western countries has increased. This increase is thought to be the result of a decrease in microbial exposure, leading to changes in the composition of the gut microbiota. It has been found that the composition of the gut microbiota differs between atopic and non-atopic children. [0003] Several randomized controlled trials have been conducted to investigate whether the treatment of the gut microbiota with probiotics (live microorganisms with immunomodulatory effects) can reduce the severity of atopic dermatitis (AD). Children with AD have a 40% chance of developing asthma in later childhood, compared to 5-10% in the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/30A23L1/308A61K35/74A61K35/741
CPCA23V2002/00A23L1/308A23L1/3014A61K35/741
Inventor K·本阿默L·M·J·尼普斯A·J·纳奥塔J·加森
Owner NV NUTRICIA
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