Preparation method for compound silver-contained antibacterial dressing

A compound and silver sulfadiazine technology, which is applied in the field of preparation of silver-containing composite fiber antibacterial dressings, can solve the problems of complex process, high investment costs, and low spinning speed, and achieve broad antibacterial spectrum, easy operation, and biocompatibility Good results

Inactive Publication Date: 2013-02-06
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Wet spinning not only requires various and bulky dope preparation and pre-spinning preparation equipment, but also coagulation bath, circulation and recovery equipment. The process is complicated, the investment cost of plant construction and equipment is large, and the spinning speed is low. Therefore, the cost higher

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Prepare the stent covering film with hemostatic and antibacterial function according to the following method:

[0016] (1) configure the sponge solution: the powder of sodium alginate and chitosan is dissolved in double distilled water at 50 degrees centigrade respectively, and the concentration is 2% (W / W). After fully dissolving for 5 hours, mix the two liquids with 9 : 1 ratio and stirred at room temperature for 30 minutes.

[0017] (2) Preparation of sponge: pour the mixed solution into a polystyrene petri dish, freeze overnight at minus 70°C, and freeze-dry at minus 50°C for 24 hours; then directly immerse the sponge in a mixture of acetone and water , volume ratio 9:1; at the same time, 50 mg of 1-ethyl (3-3-dimethylamino) carbodiimide salt (EDC) was added to the solution, and then shaken at room temperature for 24 hours.

[0018] (3) preparation of silver-loaded sponges: the silver sulfadiazine solution with a concentration of 1000 ppm is sprayed on the surface ...

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PUM

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Abstract

The invention relates to a preparation method for a compound silver-contained antibacterial dressing. The preparation method is characterized in that the antibacterial dressing comprises natural polymer materials and sulfadiazine silver; the natural polymer materials are taken as the raw materials to produce a composite fiber cavernosum material through a freeze drying technology; and the sulfadiazine silver is loaded on the cavernosum. According to the preparation method, the silver-contained antibacterial dressing is prepared through the freeze drying technology and by loading silver on the cavernosum through spraying, has good biocompatibility, and can maintain a moist environment for a wound surface to facilitate occlusion of wounds and regeneration of skin; and the antibacterial component of the silver-contained antibacterial dressing is sulfadiazine silver which has a very good sterilizing property and a wide antibiotic spectrum, so that the silver-contained antibacterial dressing can provide a favorable condition for a wound surface and guarantee quick occlusion of wounds, and has a simple production technology and an extensive application prospect.

Description

Technical field: [0001] The invention relates to a preparation method of an antibacterial dressing, in particular to a preparation method of a silver-containing composite fiber antibacterial dressing with broad-spectrum antibacterial effects. Background technique: [0002] In recent years, nonwoven fabrics made of alginate fibers have been widely used in medical dressings. Compared with traditional cotton gauze, alginate gauze has high hygroscopicity and good hemostatic performance, and can form a layer on the wet wound surface. A layer of hydrogel forms a gel layer on the surface of the wound, which protects the wound surface, protects the nerve endings from external stimuli, makes the wound feel no obvious pain, and keeps the wound surface at a certain humidity and temperature, creating a new environment for wound healing. A good healing environment can promote wound healing as soon as possible. This layer of hydrogel can not only provide a good healing environment for th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/44A61L15/32A61L15/28
Inventor 韩志超许杉杉
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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