Application of mangiferin compound or mango extraction as pancreatic lipase inhibitor and to preparation of medicament or food for preventing and treating obesity

A technology of pancreatic lipase and mangiferin, which is applied in the directions of medical preparations containing active ingredients, application, food preparation, etc., can solve the problem that the weight loss activity of mangiferin compounds has not been reported.

Active Publication Date: 2013-02-13
HAINAN LIYAOTANG BIOTECH DEV
View PDF1 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Mangiferin compounds have a wide range of pharmacological activities, such as antitussive, expectorant, asthma, central inhibition, anti-oxidation, anti-inflammatory, antibacterial, antiviral, anti-tumor, choleretic and immune regulation effects, but the effect on mangiferin The weight loss activity of similar compounds has not been reported

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of mangiferin compound or mango extraction as pancreatic lipase inhibitor and to preparation of medicament or food for preventing and treating obesity
  • Application of mangiferin compound or mango extraction as pancreatic lipase inhibitor and to preparation of medicament or food for preventing and treating obesity
  • Application of mangiferin compound or mango extraction as pancreatic lipase inhibitor and to preparation of medicament or food for preventing and treating obesity

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0122] The preparation method of the mango extract is as follows: taking fresh mango fruit or mango leaves, extracting with ethanol solution, and concentrating the obtained extraction solution into an extract to obtain the product.

[0123] The aqueous ethanol solution used for extraction is a mixture of ethanol and water. In order to improve the extraction effect, an aqueous ethanol solution with an ethanol content of 70% (volume fraction) is used.

[0124] The present invention also provides the application of a mangiferin compound with the structure shown in formula I in the preparation of medicine and / or food for treating and / or preventing obesity.

[0125]

[0126] Formula I

[0127] Among them, R 1 selected from -Glucose, -OH or -H;

[0128] R 2 selected from -OH or -OCH 3 ;

[0129] R 3 selected from -Glucose, -OH or -H.

[0130] Among them, the mangiferin compounds with the structure shown in formula I can be commercially available or prepared according to th...

Embodiment 1

[0183] Example 1 Detection of inhibitory activity of commercially available mangiferin compounds on pancreatic lipase

[0184] The internationally recognized pancreatic lipase assay method was used to determine the activity of pancreatic lipase according to the release rate of oleic acid released from triolein. The mangiferin compounds used in the test include: mangiferin, isomangiferin, homomangiferin, mangiferin aglycon, isomangiferin aglycone, and homomangiferin aglycon. All are purchased from the market.

[0185] The detection method is as follows: prepare a solution containing 0.1 mol / L N-tris(hydroxymethyl)methyl-3-aminoethanesulfonic acid (TES) and 0.1 mol / L NaCl, and adjust the pH value to 7.0, which is the detection buffer . Take 80mg of glyceryl trioleate, 10mg of lecithin and 5mg of taurocholic acid, dissolve in 9mL of detection buffer, and ultrasonicate for 5min.

[0186] Take 0.1 mL of the ultrasonically treated suspension, add 0.05 mL of pancrelipase and the s...

Embodiment 2

[0192] Example 2 Effects of Commercially Available Mangiferin Compounds on the Body Weight of High Fat-fed Mice

[0193] The method used in the experiment was as follows: 54 ICR female mice were divided into 3 groups, 18 in each group, and fed with different foods. After 8 weeks, the animals were anesthetized with ether and sacrificed. The body weight of each mouse was measured once every 2 weeks, and the food intake of each mouse was recorded 3 times a week for 8 weeks, and the effect of mango extract or mangiferin compounds on the body weight of mice fed with high fat was analyzed. The mangiferin compounds used in the test include: mangiferin, isomangiferin, homomangiferin, mangiferin aglycon, isomangiferin aglycone, and homomangiferin aglycon.

[0194] The feeding food was as follows: control group, fed with common feed; high-fat food group: feed containing 40% tallow, 36% casein, 10% cornstarch, 9% sugar, 1% mixed vitamins, 4% minerals; experimental group : Add 1% mangife...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides an application of a mangiferin compound with a structure shown as a formula I as a pancreatic lipase inhibitor, an application of a mango extract containing the mangiferin compound with the structure shown as the formula I as a pancreatic lipase inhibitor, and an application of the mangiferin compound with the structure shown as the formula I or the mango extract containing the mangiferin compound with the structure shown as the formula I to preparation of a medicament or a food for treating and/or preventing obesity, and provides an application of the mangiferin compound with the structure shown as the formula I or the mango extract containing the mangiferin compound with the structure shown as the formula I to preparation of a medicament or a food for treating and/or preventing obesity. The mangiferin compound has the function of inhibiting the activity of pancreatic lipase, so that the occurrence of obesity can be avoided by inhibiting the accumulation of in-vivo fat. Meanwhile, the mangiferin compound has wide physiological activity, so that side effects on human bodies caused by the conventional weight-losing product can be avoided.

Description

technical field [0001] The invention relates to the field of natural medicines, in particular to the application of mangiferin compounds and / or mango extracts as pancreatic lipase inhibitors and their application in the preparation of medicines and / or foods for treating or preventing obesity. Background technique [0002] Obesity refers to a certain degree of obvious overweight and thick fat layer, which is a state caused by excessive accumulation of body fat, especially triglycerides. Clinically, obesity is usually divided into three categories: simple obesity, pathological obesity and specific obesity. Among them, simple obesity is divided into: constitutional obesity, which is caused by congenital factors; acquired obesity, which is caused by overeating. The causes of morbid obesity are more complicated, and most of them are hormone secretion disorders caused by some diseases or drugs. Specific obesity mainly includes maternal obesity and postmenopausal obesity. [000...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K36/22A61P3/04A23L1/29A23L33/00
Inventor 郭志凯戴好富梅文莉王辉
Owner HAINAN LIYAOTANG BIOTECH DEV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap