Method for preparing polymer porous microspheres by high-voltage electrostatic anti-solvent process

A porous microsphere, high-voltage electrostatic technology, which is used in the preparation of microspheres, microcapsule preparations, inorganic non-active ingredients, etc., can solve the problems of hollow, non-porous and non-penetrating microsphere surfaces, etc.
CN102941043BActive Publication Date: 2015-08-05HUAQIAO UNIVERSITY
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Patents(China)
Current Assignee / Owner
HUAQIAO UNIVERSITY
Publication Date
2015-08-05

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Abstract

The present invention discloses a method of preparing porous polymer microspheres by high voltage electrostatic anti-solvent process. Under the effect of high voltage electrostatic force, water-in-oil emulsion is discharged from an injection needle and is added dropwise to an anti-solvent. The organic solvent in the water-in-oil emulsion and the anti-solvent are miscible with each other, so that the polymer droplets takes the water emulsion droplets as nucleus and are cured and precipitated on surfaces of the nucleus, and the polymer microsphere structure containing pore-foaming agent water emulsion droplets is formed. The gas generated by ammonium hydrogen carbonate decomposition inside the microspheres because of emulsification opens holes on the surfaces of the polylactic acid microspheres to generate the porous structural microspheres. The present invention can be used for preparing drug carriers for inhaled pulmonary drug delivery. The experimental results show that: porous microspheres having a large geometric particle size can be prepared under ideal process parameters; the degree of sphericity is good, the surface is rough, the surface has a large number of pores of different sizes, and the interior is filled with through-hole structure; and increasing the input amount of ammonium hydrogen carbonate, the geometric particle size of the product can be significantly improved and the aerodynamic diameter can be reduced.
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Description

technical field

[0001] The invention relates to a novel method for preparing a drug carrier, that is, a method for preparing a drug carrier by treating an emulsion with a high-voltage electrostatic antisolvent method. Specifically, the composition of the solution was changed in the conventional high-voltage electrostatic system, and the aqueous phase dissolved in the porogen was added to the single organic solution, so that the rapidly precipitated microspheres had more porous properties for pulmonary drug delivery. surface morphology. Background technique

[0002] Porous microspheres refer to microspheres with low density and hollow / porous structure formed from solid microspheres by appropriate methods. Appropriate methods include adding auxiliary materials such as porogens, and additional steps such as supercritical treatment. In terms of pharmaceutical carriers, with large geometric particle size, low density, and irregular surface morphology, it has good aerodynamic pro...

Claims

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