Method for producing Nemadectin through fermenting

Abstract

The invention discloses a method for producing Nemadectin through fermenting. In the Nemadectin production process through fermenting, carbohydrates are intermittently or continuously added to a fermentation liquid to maintain the total sugar concentration of the fermentation liquid at 10-40g / L in order to carry out fermenting production when the total sugar concentration of the fermentation liquid is less than 30g / L. The method enables the Nemadectin fermentation unit to be improved by above 50%, simultaneously has the advantages of simple production operation, low equipment requirements and low cost, and is a technology suitable for the industrialized production.

Description

technical field

[0001] The invention relates to the technical field of microbial fermentative production of antibiotics, in particular to the fermentative production of nimoctine. More specifically, it relates to a method for cultivating Streptomyces coeruleus by continuously or intermittently adding high-concentration monosaccharide, disaccharide or polysaccharide solution to the fermentation broth to produce high-concentration nemoctin. Background technique

[0002] Nemadectin is a sixteen-membered macrolide antibiotic produced by Streptomycescyaneogriseus sp.Noncyanogenus through fermentation. As a member of the milbemycin family, nimoctine is mainly used to synthesize Moxidectin, a more active pesticide and veterinary drug. Moxictine has been used as a veterinary anthelmintic since the mid-1980s. It can efficiently kill nematodes and ectoparasites, and has good safety for animals. It is currently widely used in veterinary clinics. Broad-spectrum, high-efficiency, new m...

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