Detection method for pharmaceutical composition for treating viral hepatitis
A technology of viral hepatitis and detection method, which is applied in the field of detection of pharmaceutical compositions for the treatment of viral hepatitis, and can solve problems such as drug resistance, addiction, and obvious side effects
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experiment example 1
[0037] Experimental Example 1: Pharmacodynamic test of the drug group on liver protection, enzyme reduction, choleretic, jaundice reduction, phagocytosis and clearance
[0038] Drug group I: get the pharmaceutical composition mixture prepared in Example 2 of the present invention
[0039] Drug group II: take the pharmaceutical composition mixture prepared in Example 13 of the present invention
[0040] Control group: commercially available Qingre Shugan mixture.
[0041] one. Hepatoprotective and enzyme-lowering effect
[0042] 1. Protective effect on acute liver injury
[0043] Take 84 Kunming mice, weighing 18-20g, half male and half male, and randomly divide them into 7 groups. The first group: the normal control group, fed with the same amount of drinking water every day; the second group: the model group, fed with the same amount of drinking water every day; equivalent to 9.32 g of crude drug) / kg body weight per day; the fourth group: drug group II, orally administer...
experiment example 2
[0066] Experimental Example 2 Excipient screening experiment
[0067] Optimization of Inclusion Process Conditions of Volatile Oil β-Cyclodextrin
[0068]Since the volatile oil is easy to lose, if the volatile oil is directly added, left for a long time or slightly heated, the volatile oil will be lost, thereby reducing the content and affecting the curative effect of the drug. In order to solve this problem, the method of β-cyclodextrin inclusion was adopted, and the conditions of inclusion were optimized by orthogonal experiment.
[0069] See the accompanying drawings for the experimental procedure.
[0070] Inclusion by saturated aqueous solution method: Weigh a certain amount of β-cyclodextrin, add appropriate amount of distilled water, and heat it in a water bath at 70°C to make a 5% aqueous solution of β-cyclodextrin, at different temperatures (20°C, 40°C, 60°C) stirring at a speed of 2500 rpm, adding a certain amount of volatile oil, fully stirring for a certain perio...
experiment example 3
[0080] Experimental example 3 Identification test of capillary
[0081] Preparation of Blank Samples According to the ratio of herb taste and dosage of the medicine group of the present invention, a group of medicines not containing capillary root, white peony root, angelica sinensis, salvia miltiorrhiza and Polygonum cuspidatum were prepared respectively, and blank preparations were made according to the preparation process.
[0082] Preparation of blank solution Take the daily dose of blank sample 14 / 1000 of the pharmaceutical composition preparation capillary, add 20ml of water to dissolve, extract 2 times with ethyl acetate, 30ml for the first time, 20ml for the second time, and combine the ethyl acetate solution , evaporated to dryness in a water bath, and the residue was dissolved by adding 1ml of ethyl acetate as a blank solution.
[0083] Preparation of the sample solution Take the same amount of samples of the drug group and substance, and prepare the sample solution ...
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