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Traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and preparation method thereof

A technology for cardiovascular and cerebrovascular diseases and compositions, which can be applied to cardiovascular system diseases, drug combinations, and pharmaceutical formulations, etc., and can solve problems such as inconvenient carrying, large dosage, and slow efficacy of drugs

Active Publication Date: 2013-04-03
SHANDONG WOHUA PHARMACEUTICALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Traditional Chinese patent medicines are mostly crude products that are crushed into raw medicine powder or only crudely extracted, which have disadvantages such as low content of active ingredients, large dosage, incomplete absorption, low bioavailability, slow efficacy, and inconvenient carrying.

Method used

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  • Traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and preparation method thereof
  • Traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] 1. Take Salvia miltiorrhiza, crush it, add 60% ethanol to heat and reflux for extraction 3 times, each time add water 6 times the weight of the medicinal material, each time for 1 hour; combine the extracts, adjust the pH to 2.8 with acid, let cool, centrifuge, and take the clear liquid Apply a macroporous resin column whose resin volume is 3 times that of the crude drug, first wash with water, discard the washing solution, and then elute with 2.5 times the column volume of 90% ethanol to collect the eluent; the eluent is concentrated under reduced pressure, dried, That is, Danshen extract.

[0060] 2. Take Panax notoginseng, crush it, add 4 times the weight of the medicinal material with water or 50% ethanol to heat reflux extraction or ultrasonic extraction twice, each time for 2 hours, concentrate the extract under reduced pressure, centrifuge or filter, and take the clarified liquid or filtrate; Put the clarified liquid or filtrate on an anion exchange resin column,...

Embodiment 2

[0064] Mix 600g of Danshen extract, 40g of Panax notoginseng extract, and 600g of Pueraria root extract prepared in steps 1-3 of Example 1, add powdered sugar, starch, low-substituted hydroxypropyl cellulose and other auxiliary materials in an appropriate amount to make granules 1000g.

Embodiment 3

[0066] Mix 600g of Danshen extract, 40g of Radix Notoginseng extract, and 600g of Pueraria root extract prepared in steps 1-3 of Example 1, add starch, appropriate amount of auxiliary materials such as low-substituted hydroxypropyl cellulose, make granules, and pack into capsules 1000g grain.

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Abstract

The invention relates to a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine extracts in parts by weight: 20-40 parts of salvia miltiorrhiza extracts, 1-3 parts of notoginseng extracts, and 20-40 parts of pueraria extracts.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique: [0002] Cardiovascular and cerebrovascular diseases are serious diseases that endanger human health and life, and are called "the number one killer of human beings" by the World Health Organization. In my country, there are about 1.95 million new cardiovascular patients every year, and nearly 1.56 million people die of cardiovascular diseases. The mortality rate of cardiovascular and cerebrovascular diseases has reached 35%, ranking first in the mortality rate of various diseases. Among the 5-7 million cardiovascular patients who survive, 75% of them have different disabilities, causing a heavy burden to society and families. By the end of 2000, there were 130 million people over the age of 60 in China. Middle-aged...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P9/00A61P9/10
Inventor 曾英姿周万辉于洪亮赵磊高燕
Owner SHANDONG WOHUA PHARMACEUTICALS CO LTD
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