Correlation module identifying method based on 2-type heterogeneous network
A heterogeneous network and recognition method technology, applied in the field of computer data processing, can solve problems such as bipartite graph model limitations and data incompleteness, core interaction relationship mining and new interaction relationship prediction deviations, etc., to achieve a wide range of applications , the result is accurate and reliable
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[0065] Example: Mining the core correlation module of the molecular network between the formula Maxing Shigan-Yinqiao San and H1N1 influenza.
[0066] Also refer to image 3 This embodiment of the present invention will be described.
[0067] S0, preprocessing
[0068] By consulting experts in traditional Chinese medicine and searching literature, the 12 Chinese herbal medicines and the chemical components contained in the formula of Maxing Shigan-Yinqiao powder were obtained. The 12 kinds of Chinese medicinal materials are: licorice, roasted ephedra, artemisia annua, silver flower, scutellaria, forsythia, mint, fried almonds, burdock seeds, anemarrhena, fritillaria, and gypsum. There are 449 compounds included in the PubChem database. ADMET Predictor was used to evaluate the drug-likeness of the compounds, and the compounds with high ADMET risk were eliminated. Finally, 344 drug-like chemical constituents were retained.
[0069] Through the KEGG Pathway database, 174 gen...
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